دورية أكاديمية
Maternal separation enhances anticontractile perivascular adipose tissue function in male rats on a high-fat diet.
| العنوان: | Maternal separation enhances anticontractile perivascular adipose tissue function in male rats on a high-fat diet. |
|---|---|
| المؤلفون: | Loria AS; Department of Pharmacology and Nutritional Sciences, University of Kentucky , Lexington, Kentucky., Spradley FT; Department of Surgery, University of Mississippi Medical Center , Jackson, Mississippi., Obi IE; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama., Becker BK; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama., De Miguel C; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama., Speed JS; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama., Pollock DM; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia., Pollock JS; Cardio-Renal Physiology and Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama.; Department of Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia. |
| المصدر: | American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2018 Dec 01; Vol. 315 (6), pp. R1085-R1095. Date of Electronic Publication: 2018 Sep 26. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society |
| مواضيع طبية MeSH: | Maternal Deprivation*, Adipose Tissue/*physiopathology , Diet, High-Fat/*adverse effects , Obesity/*physiopathology, Angiotensin II/pharmacology ; Animals ; Aorta, Thoracic/drug effects ; Male ; Nitric Oxide/pharmacology ; Rats ; Vasoconstriction/drug effects |
| مستخلص: | Clinical studies have shown that obesity negatively impacts large arteries' function. We reported that rats exposed to maternal separation (MatSep), a model of early life stress, display enhanced angiotensin II (ANG II)-induced vasoconstriction in aortic rings cleaned of perivascular adipose tissue (PVAT) under normal diet (ND) conditions. We hypothesized that exposure to MatSep promotes a greater loss of PVAT-mediated protective effects on vascular function and loss of blood pressure (BP) rhythm in rats fed a high-fat diet (HFD) when compared with controls. MatSep was performed in male Wistar-Kyoto rats from days 2 to 14 of life. Normally reared littermates served as controls. On ND, aortic rings from MatSep rats with PVAT removed showed increased ANG II-mediated vasoconstriction versus controls; however, rings from MatSep rats with intact PVAT displayed blunted constriction. This effect was exacerbated by an HFD in both groups; however, the anticontractile effect of PVAT was greater in MatSep rats. Acetylcholine-induced relaxation was similar in MatSep and control rats fed an ND, regardless of the presence of PVAT. HFD impaired aortic relaxation in rings without PVAT from MatSep rats, whereas the presence of PVAT improved relaxation in both groups. On an HFD, immunolocalization of vascular smooth muscle-derived ANG-(1-7) and PVAT-derived adiponectin abundances were increased in MatSep. In rats fed an HFD, 24-h BP and BP rhythms were similar between groups. In summary, MatSep enhanced the ability of PVAT to blunt the heightened ANG II-induced vasoconstriction and endothelial dysfunction in rats fed an HFD. This protective effect may be mediated via the upregulation of vasoprotective factors within the adipovascular axis. |
| References: | Dis Model Mech. 2012 Sep;5(5):691-7. (PMID: 22773756) Hypertens Res. 2010 May;33(5):446-53. (PMID: 20186150) Atherosclerosis. 2010 Jun;210(2):656-61. (PMID: 20152980) Hypertens Res. 2008 Jul;31(7):1415-23. (PMID: 18957813) Circulation. 2015 May 12;131(19):1674-81. (PMID: 25858196) Chronobiol Int. 2007;24(6):1081-94. (PMID: 18075800) Arch Pediatr Adolesc Med. 2009 Dec;163(12):1135-43. (PMID: 19996051) Hypertension. 2017 Mar;69(3):435-442. (PMID: 28093467) Int J Obes Relat Metab Disord. 2004 Dec;28 Suppl 4:S58-65. (PMID: 15592488) Circulation. 2015 Dec 1;132(22):2134-45. (PMID: 26362633) Vasc Health Risk Manag. 2013;9:105-16. (PMID: 23576873) Adv Pharmacol. 2010;60:229-55. (PMID: 21081220) Vasc Med. 2007 Aug;12(3):183-8. (PMID: 17848474) Behav Brain Res. 2007 Oct 1;183(1):25-30. (PMID: 17604851) J Mol Endocrinol. 2006 Jun;36(3):485-501. (PMID: 16720718) Hypertension. 2011 Oct;58(4):619-26. (PMID: 21876076) FASEB J. 2019 Jan;33(1):175-180. (PMID: 29965796) Arterioscler Thromb Vasc Biol. 2010 May;30(5):953-61. (PMID: 20203301) Circulation. 2011 Sep 6;124(10):1160-71. (PMID: 21844078) N Engl J Med. 2017 Jul 6;377(1):13-27. (PMID: 28604169) Hypertension. 2016 May;67(5):897-905. (PMID: 27045029) Curr Vasc Pharmacol. 2016;14(2):168-74. (PMID: 26638793) Dev Psychobiol. 1984 Nov;17(6):587-600. (PMID: 6510554) Arterioscler Thromb Vasc Biol. 2007 Nov;27(11):2348-54. (PMID: 17823369) Cardiovasc Res. 2007 Sep 1;75(4):719-27. (PMID: 17617391) J Am Heart Assoc. 2012 Dec;1(6):e004200. (PMID: 23316328) PLoS One. 2013 Aug 13;8(8):e71271. (PMID: 23967179) Physiol Meas. 2010 Sep;31(9):1185-201. (PMID: 20664161) Clin Exp Hypertens A. 1991;13(2):277-96. (PMID: 2065467) Chronobiol Int. 2001 Jul;18(4):665-81. (PMID: 11587089) Atherosclerosis. 2003 Feb;166(2):253-9. (PMID: 12535737) Physiol Rep. 2015 May;3(5):. (PMID: 25999404) J Clin Endocrinol Metab. 2014 Jun;99(6):E1055-60. (PMID: 24650014) Neurochem Res. 2013 Apr;38(4):826-33. (PMID: 23389660) Am J Physiol Regul Integr Comp Physiol. 2013 Jan 15;304(2):R121-9. (PMID: 23174859) Am J Pathol. 2017 Jun;187(6):1426-1435. (PMID: 28432873) Curr Vasc Pharmacol. 2014 May;12(3):403-11. (PMID: 24846230) Neurosci Biobehav Rev. 2017 Mar;74(Pt B):453-465. (PMID: 27450581) Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H621-33. (PMID: 22140039) Hypertension. 2002 Oct;40(4):441-7. (PMID: 12364344) Circulation. 2009 Mar 31;119(12):1661-70. (PMID: 19289637) Am J Physiol Heart Circ Physiol. 2008 Oct;295(4):H1514-21. (PMID: 18689498) Br J Pharmacol. 2012 Feb;165(3):633-42. (PMID: 21486288) J Hypertens. 2009 Apr;27(4):782-90. (PMID: 19516177) Pharmacol Res. 2011 Jan;63(1):68-76. (PMID: 20969959) Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7825-7830. (PMID: 29991600) J Biol Chem. 2003 Nov 7;278(45):45021-6. (PMID: 12944390) Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1468-78. (PMID: 26371173) Am J Physiol Renal Physiol. 2017 Jul 1;313(1):F47-F54. (PMID: 28331064) Int J Obes (Lond). 2018 Apr;42(4):923-925. (PMID: 28978977) Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2558-64. (PMID: 18408126) Am J Physiol Endocrinol Metab. 2017 Feb 1;312(2):E98-E108. (PMID: 27965205) Circ J. 2010 Jul;74(7):1479-87. (PMID: 20526041) Diabetes Care. 2004 Jun;27(6):1487-95. (PMID: 15161807) Hypertension. 2010 Feb;55(2):494-9. (PMID: 20026758) Am J Hypertens. 2003 Jun;16(6):467-72. (PMID: 12799095) Int J Biochem Cell Biol. 2003 Jun;35(6):807-25. (PMID: 12676168) J Nutr Biochem. 2013 Dec;24(12):2003-15. (PMID: 24120291) Cell Tissue Res. 2009 Jan;335(1):165-89. (PMID: 18941783) Hypertension. 2012 Nov;60(5):1273-9. (PMID: 23045458) Endocrinology. 2010 Jul;151(7):3299-306. (PMID: 20410199) Clin Sci (Lond). 2002 Oct;103(4):371-7. (PMID: 12241535) Sci Rep. 2015 Jun 15;5:11417. (PMID: 26073568) Science. 2000 Sep 29;289(5488):2344-7. (PMID: 11009419) Stress. 2012 Jul;15(4):457-70. (PMID: 22085295) Int J Biochem Cell Biol. 2003 Jun;35(6):826-37. (PMID: 12676169) |
| معلومات مُعتمدة: | T32 HL007918 United States HL NHLBI NIH HHS; R00 HL130577 United States HL NHLBI NIH HHS; K99 HL111354 United States HL NHLBI NIH HHS; P20 GM121334 United States GM NIGMS NIH HHS; P01 HL095499 United States HL NHLBI NIH HHS; R00 HL111354 United States HL NHLBI NIH HHS; R01 HL135158 United States HL NHLBI NIH HHS; T32 DK007545 United States DK NIDDK NIH HHS; R00 HL127178 United States HL NHLBI NIH HHS; T32 HL007457 United States HL NHLBI NIH HHS |
| فهرسة مساهمة: | Keywords: PVAT; early life stress; high-fat diet; maternal separation; vascular reactivity |
| المشرفين على المادة: | 11128-99-7 (Angiotensin II) 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20180927 Date Completed: 20190829 Latest Revision: 20200930 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6425636 |
| DOI: | 10.1152/ajpregu.00197.2018 |
| PMID: | 30256681 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1490 |
|---|---|
| DOI: | 10.1152/ajpregu.00197.2018 |