دورية أكاديمية
أعرض في EDS

Small RNA sequencing of sessile serrated polyps identifies microRNA profile associated with colon cancer.

التفاصيل البيبلوغرافية
العنوان: Small RNA sequencing of sessile serrated polyps identifies microRNA profile associated with colon cancer.
المؤلفون: Kanth P; Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.; Huntsman Cancer Institute, Salt Lake City, Utah., Hazel MW; Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah., Boucher KM; Huntsman Cancer Institute, Salt Lake City, Utah.; Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah., Yang Z; Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut., Wang L; Department of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut.; Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.; Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, Connecticut., Bronner MP; Huntsman Cancer Institute, Salt Lake City, Utah.; Department of Pathology, University of Utah, Salt Lake City, Utah., Boylan KE; Department of Pathology, University of Utah, Salt Lake City, Utah., Burt RW; Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.; Huntsman Cancer Institute, Salt Lake City, Utah., Westover M; Huntsman Cancer Institute, Salt Lake City, Utah., Neklason DW; Huntsman Cancer Institute, Salt Lake City, Utah.; Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah., Delker DA; Division of Gastroenterology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.
المصدر: Genes, chromosomes & cancer [Genes Chromosomes Cancer] 2019 Jan; Vol. 58 (1), pp. 23-33. Date of Electronic Publication: 2018 Nov 18.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 9007329 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2264 (Electronic) Linking ISSN: 10452257 NLM ISO Abbreviation: Genes Chromosomes Cancer Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley-Liss
Original Publication: New York : A.R. Liss, c1989-
مواضيع طبية MeSH: Adenoma/*genetics , Colonic Neoplasms/*genetics , Colonic Polyps/*genetics , MicroRNAs/*genetics, Adenoma/pathology ; Aged ; Animals ; Biomarkers, Tumor/genetics ; Colonic Neoplasms/pathology ; Colonic Polyps/pathology ; Female ; Humans ; Male ; Middle Aged ; Sequence Analysis, RNA ; Thoracica/genetics
مستخلص: Sessile serrated adenoma/polyps (SSA/Ps) of the colon account for 20-30% of all colon cancers. Small non-coding RNAs, including microRNAs (miRNAs), may function as oncogenes or tumor suppressor genes involved in cancer development. Small RNA sequencing (RNA-seq) was used to characterize miRNA profiles in SSA/Ps, hyperplastic polyps (HPs), adenomatous polyps and paired uninvolved colon. Our 108 small RNA-seq samples' results were compared to small RNA-seq data from 212 colon cancers from the Cancer Genome Atlas. Twenty-three and six miRNAs were differentially expressed in SSA/Ps compared to paired uninvolved colon and HPs, respectively. Differential expression of MIR31-5p, MIR135B-5p and MIR378A-5p was confirmed by RT-qPCR. SSA/P-specific miRNAs are similarly expressed in colon cancers containing genomic aberrations described in serrated cancers. Correlation of miRNA expression with consensus molecular subtypes suggests more than one subtype is associated with the serrated neoplasia pathway. Canonical pathway analysis suggests many of these miRNAs target growth factor signaling pathways.
(© 2018 Wiley Periodicals, Inc.)
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معلومات مُعتمدة: R21 CA191507 United States CA NCI NIH HHS; CA191507 United States NH NIH HHS
فهرسة مساهمة: Keywords: RNA sequencing; colon cancer; gene expression; hyperplastic polyps; microRNAs; sessile serrated adenoma/polyps
المشرفين على المادة: 0 (Biomarkers, Tumor)
0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20180929 Date Completed: 20190222 Latest Revision: 20200225
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6437779
DOI: 10.1002/gcc.22686
PMID: 30265426
قاعدة البيانات: MEDLINE
الوصف
تدمد:1098-2264
DOI:10.1002/gcc.22686