دورية أكاديمية
أعرض في EDS

IFITM proteins inhibit HIV-1 protein synthesis.

التفاصيل البيبلوغرافية
العنوان: IFITM proteins inhibit HIV-1 protein synthesis.
المؤلفون: Lee WJ; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, United Kingdom., Fu RM; Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom., Liang C; McGill University AIDS Centre, Lady Davis Institute, Montreal, Quebec, H3T 1E2, Canada., Sloan RD; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, United Kingdom. richard.sloan@ed.ac.uk.; Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom. richard.sloan@ed.ac.uk.; ZJU-UoE Institute, Zhejiang University, Haining, Zhejiang, 314400, P.R. China. richard.sloan@ed.ac.uk.
المصدر: Scientific reports [Sci Rep] 2018 Sep 28; Vol. 8 (1), pp. 14551. Date of Electronic Publication: 2018 Sep 28.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Antigens, Differentiation/*metabolism , HIV Infections/*metabolism , HIV-1/*physiology , Membrane Proteins/*metabolism , RNA-Binding Proteins/*metabolism , Viral Proteins/*metabolism, HEK293 Cells ; Humans ; Protein Biosynthesis ; Virus Replication
مستخلص: Interferon induced transmembrane proteins (IFITMs) inhibit the cellular entry of a broad range of viruses, but it has been suspected that for HIV-1 IFITMs may also inhibit a post-integration replicative step. We show that IFITM expression reduces HIV-1 viral protein synthesis by preferentially excluding viral mRNA transcripts from translation and thereby restricts viral production. Codon-optimization of proviral DNA rescues viral translation, implying that IFITM-mediated restriction requires recognition of viral RNA elements. In addition, we find that expression of the viral accessory protein Nef can help overcome the IFITM-mediated inhibition of virus production. Our studies identify a novel role for IFITMs in inhibiting HIV replication at the level of translation, but show that the effects can be overcome by the lentiviral protein Nef.
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (Antigens, Differentiation)
0 (IFITM2 protein, human)
0 (IFITM3 protein, human)
0 (Membrane Proteins)
0 (RNA-Binding Proteins)
0 (Viral Proteins)
0 (leu-13 antigen)
تواريخ الأحداث: Date Created: 20180930 Date Completed: 20191111 Latest Revision: 20240211
رمز التحديث: 20240211
مُعرف محوري في PubMed: PMC6162285
DOI: 10.1038/s41598-018-32785-5
PMID: 30266929
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-018-32785-5