دورية أكاديمية
أعرض في EDS

Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research.

التفاصيل البيبلوغرافية
العنوان: Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research.
المؤلفون: Ehrlich AT; IGBMC, Institut Génétique Biologie Moléculaire Cellulaire, Illkirch, France.; Douglas Mental Health University Institute and McGill University, Department of Psychiatry, Montreal, Canada., Maroteaux G; Douglas Mental Health University Institute and McGill University, Department of Psychiatry, Montreal, Canada.; INSERM U1151 Institut Necker Enfants Malades, 75014, Paris, France., Robe A; IGBMC, Institut Génétique Biologie Moléculaire Cellulaire, Illkirch, France., Venteo L; Label Histologie, 51100, Reims, France., Nasseef MT; Douglas Mental Health University Institute and McGill University, Department of Psychiatry, Montreal, Canada., van Kempen LC; Lady Davis Institute for Medical Research, Jewish General Hospital and McGill University, Department of Pathology, Montreal, Canada.; Department of Pathology, Laboratory for Molecular Pathology, University Medical Centre Groningen, Groningen, The Netherlands., Mechawar N; Douglas Mental Health University Institute and McGill University, Department of Psychiatry, Montreal, Canada., Turecki G; Douglas Mental Health University Institute and McGill University, Department of Psychiatry, Montreal, Canada., Darcq E; Douglas Mental Health University Institute and McGill University, Department of Psychiatry, Montreal, Canada., Kieffer BL; IGBMC, Institut Génétique Biologie Moléculaire Cellulaire, Illkirch, France. brigitte.kieffer@douglas.mcgill.ca.; Douglas Mental Health University Institute and McGill University, Department of Psychiatry, Montreal, Canada. brigitte.kieffer@douglas.mcgill.ca.
المصدر: Communications biology [Commun Biol] 2018 Aug 06; Vol. 1, pp. 102. Date of Electronic Publication: 2018 Aug 06 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: eCollection Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
مستخلص: Orphan G-protein-coupled receptors (oGPCRs) possess untapped potential for drug discovery. In the brain, oGPCRs are generally expressed at low abundance and their function is understudied. Expression profiling is an essential step to position oGPCRs in brain function and disease, however public databases provide only partial information. Here, we fine-map expression of 78 brain-oGPCRs in the mouse, using customized probes in both standard and supersensitive in situ hybridization. Images are available at http://ogpcr-neuromap.douglas.qc.ca. This searchable database contains over 8000 coronal brain sections across 1350 slides, providing the first public mapping resource dedicated to oGPCRs. Analysis with public mouse (60 oGPCRs) and human (56 oGPCRs) genome-wide datasets identifies 25 oGPCRs with potential to address emotional and/or cognitive dimensions of psychiatric conditions. We probe their expression in postmortem human brains using nanoString, and included data in the resource. Correlating human with mouse datasets reveals excellent suitability of mouse models for oGPCRs in neuropsychiatric research.
Competing Interests: The authors declare no competing interests.
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تواريخ الأحداث: Date Created: 20181002 Latest Revision: 20200111
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6123746
DOI: 10.1038/s42003-018-0106-7
PMID: 30271982
قاعدة البيانات: MEDLINE
الوصف
تدمد:2399-3642
DOI:10.1038/s42003-018-0106-7