دورية أكاديمية
أعرض في EDS

Antimicrobial Coatings from Hybrid Nanoparticles of Biocompatible and Antimicrobial Polymers.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial Coatings from Hybrid Nanoparticles of Biocompatible and Antimicrobial Polymers.
المؤلفون: Galvão CN; Biocolloids Laboratory, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. carolinagalvao@usp.br., Sanches LM; Biocolloids Laboratory, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. luccas.sanches@hotmail.com., Mathiazzi BI; Biocolloids Laboratory, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. bemathi@usp.br., Ribeiro RT; Biocolloids Laboratory, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. rodrigo@iq.usp.br., Petri DFS; Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. dfsp@usp.br., Carmona-Ribeiro AM; Biocolloids Laboratory, Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil. amcr@usp.br.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2018 Sep 28; Vol. 19 (10). Date of Electronic Publication: 2018 Sep 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Coated Materials, Biocompatible/*pharmacology , Nanoparticles/*chemistry , Polymers/*pharmacology, Colloids ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Nanoparticles/ultrastructure ; Polyethylenes/pharmacology ; Polymethyl Methacrylate/pharmacology ; Quaternary Ammonium Compounds/pharmacology ; Solvents ; Staphylococcus aureus/drug effects ; Surface-Active Agents/pharmacology
مستخلص: Hybrid nanoparticles of poly(methylmethacrylate) synthesized in the presence of poly (diallyldimethyl ammonium) chloride by emulsion polymerization exhibited good colloidal stability, physical properties, and antimicrobial activity but their synthesis yielded poor conversion. Here we create antimicrobial coatings from casting and drying of the nanoparticles dispersions onto model surfaces such as those of silicon wafers, glass coverslips, or polystyrene sheets and optimize conversion using additional stabilizers such as cetyltrimethyl ammonium bromide, dioctadecyldimethyl ammonium bromide, or soybean lecithin during nanoparticles synthesis. Methodology included dynamic light scattering, determination of wettability, ellipsometry of spin-coated films, scanning electron microscopy, and determination of colony forming unities (log CFU/mL) of bacteria after 1 h interaction with the coatings. The additional lipids and surfactants indeed improved nanoparticle synthesis, substantially increasing the conversion rates by stabilizing the monomer droplets in dispersion during the polymerization. The coatings obtained by spin-coating or casting of the nanoparticles dispersions onto silicon wafers were hydrophilic with contact angles increasing with the amount of the cationic polymer in the nanoparticles. Against Escherichia coli and Staphylococcus aureus , bacteria cell counts were reduced by approximately 7 logs upon interaction with the coatings, revealing their potential for several biotechnological and biomedical applications.
References: Expert Opin Drug Deliv. 2013 Jan;10(1):131-49. (PMID: 23102011)
Biomimetics (Basel). 2017 Oct 20;2(4):. (PMID: 31105181)
ACS Appl Mater Interfaces. 2011 Jun;3(6):1933-9. (PMID: 21591705)
Langmuir. 2010 Jul 20;26(14):12300-6. (PMID: 20578678)
J Biol Chem. 1966 May 25;241(10):2461-6. (PMID: 4223640)
J Lipid Res. 1999 Aug;40(8):1495-500. (PMID: 10428986)
J Phys Chem B. 2006 May 25;110(20):10070-4. (PMID: 16706467)
J Antimicrob Chemother. 2006 Oct;58(4):760-7. (PMID: 16885181)
J Phys Chem B. 2008 Aug 7;112(31):9301-10. (PMID: 18630858)
J Nanobiotechnology. 2008 May 07;6:6. (PMID: 18462496)
J Clin Microbiol. 1996 Mar;34(3):543-9. (PMID: 8904411)
J Nanobiotechnology. 2015 Sep 24;13:58. (PMID: 26404400)
Chem Phys Lipids. 2008 Mar;152(1):38-45. (PMID: 18258186)
Acta Biomater. 2014 May;10(5):2105-11. (PMID: 24434534)
Nanomaterials (Basel). 2017 Dec 02;7(12):. (PMID: 29207496)
Soft Matter. 2013 Feb 28;8(8):2423-2431. (PMID: 23807896)
Curr Top Med Chem. 2018;18(1):22-41. (PMID: 29412108)
Biomacromolecules. 2009 Nov 9;10(11):2976-86. (PMID: 19795886)
Int J Mol Sci. 2015 Mar 19;16(3):6337-52. (PMID: 25809608)
Int J Mol Sci. 2013 May 10;14(5):9906-46. (PMID: 23665898)
Int J Environ Res Public Health. 2018 Jul 04;15(7):. (PMID: 29973521)
Langmuir. 2013 Aug 6;29(31):9677-84. (PMID: 23841487)
Toxicol Appl Pharmacol. 2013 Nov 1;272(3):703-12. (PMID: 23933530)
J Phys Chem B. 2006 Apr 13;110(14):7090-4. (PMID: 16599468)
معلومات مُعتمدة: 302352/2014-7 Conselho Nacional de Desenvolvimento Científico e Tecnológico
فهرسة مساهمة: Keywords: Escherichia coli; Staphylococcus aureus; antimicrobial polymer; bacteria viability; bactericidal coatings; biocompatible polymer; coatings from nanoparticles; coatings wettability; dynamic light scattering; microbicidal coatings
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Coated Materials, Biocompatible)
0 (Colloids)
0 (Polyethylenes)
0 (Polymers)
0 (Quaternary Ammonium Compounds)
0 (Solvents)
0 (Surface-Active Agents)
26062-79-3 (poly-N,N-dimethyl-N,N-diallylammonium chloride)
9011-14-7 (Polymethyl Methacrylate)
تواريخ الأحداث: Date Created: 20181003 Date Completed: 20190117 Latest Revision: 20231004
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6213362
DOI: 10.3390/ijms19102965
PMID: 30274201
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms19102965