دورية أكاديمية

Coronary fractional flow reserve derived from intravascular ultrasound imaging: Validation of a new computational method of fusion between anatomy and physiology.

التفاصيل البيبلوغرافية
العنوان: Coronary fractional flow reserve derived from intravascular ultrasound imaging: Validation of a new computational method of fusion between anatomy and physiology.
المؤلفون: Bezerra CG; Division of Interventional Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.; Division of Cardiology, Sirio-Libanes Hospital, Sao Paulo, Brazil.; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, São Paulo, Brazil., Hideo-Kajita A; MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, Washington, District of Columbia.; Division of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia., Bulant CA; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, São Paulo, Brazil.; National Laboratory for Scientific Computing, LNCC/MCTIC, Petrópolis, Brazil., Maso-Talou GD; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, São Paulo, Brazil.; National Laboratory for Scientific Computing, LNCC/MCTIC, Petrópolis, Brazil., Mariani J Jr; Division of Interventional Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.; Division of Cardiology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Pinton FA; Division of Interventional Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.; Division of Cardiology, Sirio-Libanes Hospital, Sao Paulo, Brazil., Falcão BAA; Division of Interventional Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.; Division of Cardiology, Sirio-Libanes Hospital, Sao Paulo, Brazil., Esteves-Filho A; Division of Interventional Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.; Division of Cardiology, Sirio-Libanes Hospital, Sao Paulo, Brazil., Franken M; Division of Cardiology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil., Feijóo RA; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, São Paulo, Brazil.; National Laboratory for Scientific Computing, LNCC/MCTIC, Petrópolis, Brazil., Kalil-Filho R; Division of Interventional Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.; Division of Cardiology, Sirio-Libanes Hospital, Sao Paulo, Brazil., Garcia-Garcia HM; MedStar Cardiovascular Research Network, MedStar Washington Hospital Center, Washington, District of Columbia.; Division of Interventional Cardiology, MedStar Washington Hospital Center, Washington, District of Columbia., Blanco PJ; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, São Paulo, Brazil.; National Laboratory for Scientific Computing, LNCC/MCTIC, Petrópolis, Brazil., Lemos PA; Division of Interventional Cardiology, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Brazil.; National Institute of Science and Technology in Medicine Assisted by Scientific Computing, INCT-MACC, São Paulo, Brazil.; Division of Cardiology, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
المصدر: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions [Catheter Cardiovasc Interv] 2019 Feb 01; Vol. 93 (2), pp. 266-274. Date of Electronic Publication: 2018 Sep 12.
نوع المنشور: Comparative Study; Journal Article; Validation Study
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 100884139 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-726X (Electronic) Linking ISSN: 15221946 NLM ISO Abbreviation: Catheter Cardiovasc Interv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Wiley-Liss, c1999-
مواضيع طبية MeSH: Algorithms* , Fractional Flow Reserve, Myocardial* , Imaging, Three-Dimensional*, Coronary Artery Disease/*diagnostic imaging , Coronary Vessels/*diagnostic imaging , Ultrasonography, Interventional/*methods, Aged ; Cardiac Catheterization ; Coronary Angiography ; Coronary Artery Disease/physiopathology ; Coronary Vessels/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Reproducibility of Results
مستخلص: Objectives: To evaluate the diagnostic performance of a novel computational algorithm based on three-dimensional intravascular ultrasound (IVUS) imaging in estimating fractional flow reserve (IVUS FR ), compared to gold-standard invasive measurements (FFR INVAS ).
Background: IVUS provides accurate anatomical evaluation of the lumen and vessel wall and has been validated as a useful tool to guide percutaneous coronary intervention. However, IVUS poorly represents the functional status (i.e., flow-related information) of the imaged vessel.
Methods: Patients with known or suspected stable coronary disease scheduled for elective cardiac catheterization underwent FFR INVAS measurement and IVUS imaging in the same procedure to evaluate intermediate lesions. A processing methodology was applied on IVUS to generate a computational mesh condensing the geometric characteristics of the vessel. Computation of IVUS FR was obtained from patient-level morphological definition of arterial districts and from territory-specific boundary conditions. FFR INVAS measurements were dichotomized at the 0.80 threshold to define hemodynamically significant lesions.
Results: A total of 24 patients with 34 vessels were analyzed. IVUS FR significantly correlated (r = 0.79; P < 0.001) and showed good agreement with FFR INVAS , with a mean difference of -0.008 ± 0.067 (P = 0.47). IVUS FR presented an overall accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of 91%, 89%, 92%, 80%, and 96%, respectively, to detect significant stenosis.
Conclusion: The computational processing of IVUS FR is a new method that allows the evaluation of the functional significance of coronary stenosis in an accurate way, enriching the anatomical information of grayscale IVUS.
(© 2018 Wiley Periodicals, Inc.)
التعليقات: Comment in: Catheter Cardiovasc Interv. 2019 Feb 1;93(2):275-277. (PMID: 30719854)
فهرسة مساهمة: Keywords: computational fluid dynamics; coronary artery disease; coronary blood flow/physiology/microvascular function; fractional flow reserve; imaging intravascular ultrasound; interventional devices/innovation; quantitative coronary angiography; three-dimensional coronary models
تواريخ الأحداث: Date Created: 20181003 Date Completed: 20200210 Latest Revision: 20200210
رمز التحديث: 20240628
DOI: 10.1002/ccd.27822
PMID: 30277641
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-726X
DOI:10.1002/ccd.27822