دورية أكاديمية
Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food.
| العنوان: | Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. |
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| المؤلفون: | Holt MK; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, U.K., Richards JE; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, U.K., Cook DR; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, U.K., Brierley DI; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, U.K., Williams DL; Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, FL., Reimann F; Institute of Metabolic Science and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, U.K., Gribble FM; Institute of Metabolic Science and MRC Metabolic Diseases Unit, Addenbrooke's Hospital, University of Cambridge, Cambridge, U.K., Trapp S; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, U.K. s.trapp@ucl.ac.uk. |
| المصدر: | Diabetes [Diabetes] 2019 Jan; Vol. 68 (1), pp. 21-33. Date of Electronic Publication: 2018 Oct 02. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Diabetes Association Country of Publication: United States NLM ID: 0372763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1939-327X (Electronic) Linking ISSN: 00121797 NLM ISO Abbreviation: Diabetes Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Alexandria, VA : American Diabetes Association Original Publication: [New York, American Diabetes Association] |
| مواضيع طبية MeSH: | Brain/*metabolism , Glucagon-Like Peptide 1/*metabolism , Solitary Nucleus/*metabolism, Animals ; Eating/physiology ; Electrophysiology ; Female ; Glucose Tolerance Test ; Immunohistochemistry ; Male ; Mice ; Obesity/metabolism ; Proglucagon/metabolism |
| مستخلص: | Centrally administered glucagon-like peptide 1 (GLP-1) supresses food intake. Here we demonstrate that GLP-1-producing (PPG) neurons in the nucleus tractus solitarii (NTS) are the predominant source of endogenous GLP-1 within the brain. Selective ablation of NTS PPG neurons by viral expression of diphtheria toxin subunit A substantially reduced active GLP-1 concentrations in brain and spinal cord. Contrary to expectations, this loss of central GLP-1 had no significant effect on the ad libitum feeding of mice, affecting neither daily chow intake nor body weight or glucose tolerance. Only after bigger challenges to homeostasis were PPG neurons necessary for food intake control. PPG-ablated mice increased food intake after a prolonged fast and after a liquid diet preload. Consistent with our ablation data, acute inhibition of hM (© 2018 by the American Diabetes Association.) |
| التعليقات: | Comment in: Diabetes. 2019 Jan;68(1):15-17. (PMID: 30573675) |
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| معلومات مُعتمدة: | MC_UU_12012/3 United Kingdom MRC_ Medical Research Council; MR/N02589X/1 United Kingdom MRC_ Medical Research Council; FS/14/43/30960 United Kingdom BHF_ British Heart Foundation; MC_UU_00014/5 United Kingdom MRC_ Medical Research Council; MR/J013293/2 United Kingdom MRC_ Medical Research Council; R01 DK095757 United States DK NIDDK NIH HHS; MC_UU_00014/3 United Kingdom MRC_ Medical Research Council |
| المشرفين على المادة: | 55963-74-1 (Proglucagon) 89750-14-1 (Glucagon-Like Peptide 1) |
| تواريخ الأحداث: | Date Created: 20181004 Date Completed: 20190325 Latest Revision: 20210109 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6314470 |
| DOI: | 10.2337/db18-0729 |
| PMID: | 30279161 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1939-327X |
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| DOI: | 10.2337/db18-0729 |