دورية أكاديمية
The flavonoid acetylpectolinarin counteracts the effects of low ethanol on spontaneous network activity in hippocampal cultures.
| العنوان: | The flavonoid acetylpectolinarin counteracts the effects of low ethanol on spontaneous network activity in hippocampal cultures. |
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| المؤلفون: | Botalova A; Department of Zoology, Perm State University, Perm, Russia., Bombela T; Department of Botany, Perm Pharmaceutical Academy, Perm, Russia., Zubov P; Department of Botany, Perm Pharmaceutical Academy, Perm, Russia., Segal M; Department of Neurobiology, The Weizmann Institute Rehovot, Israel., Korkotian E; Department of Zoology, Perm State University, Perm, Russia; Department of Neurobiology, The Weizmann Institute Rehovot, Israel. Electronic address: Eduard.korkotian@weizmann.ac.il. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2019 Jan 30; Vol. 229, pp. 22-28. Date of Electronic Publication: 2018 Oct 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Linaria*, Chromones/*pharmacology , Ethanol/*adverse effects , Flavonoids/*pharmacology , Hippocampus/*drug effects , Plant Extracts/*pharmacology, Apamin/pharmacology ; Hippocampus/physiology ; Medicine, Traditional ; Potassium Channel Blockers/pharmacology ; Russia |
| مستخلص: | Ethnopharmacological Relevance: A major concern in modern society involves the lasting detrimental behavioral effects of exposure to alcoholic beverages. Consequently, hundreds of folk remedies for hangover have been suggested, most of them without a scientific basis, for lack of proper test systems. Over centuries, yellow toadflax (Linaria vulgaris Mill., Lv) tincture has been used in Russian traditional medicine to treat the spectrum of hangover symptoms such as vertigo, headache, drunken behaviors, and as a sedative. Materials and Methods: Here we use in-vitro cultured hippocampal neurons to examine the effect of the Lv extract as well as the flavonoid acetylpectolinarin (ACP) exclusively found in Lv extract, on spontaneous network activity of the cultured neurons exposed to low, physiological concentrations of ethanol. Results: As in previous studies, low (0.25-0.5%) ethanol causes an increase in network activity, which was converted to suppression, with high concentrations of ethanol. Lv extract and ACP, at low concentrations, had no appreciable effect on spontaneous activity, but they blocked the facilitating action of low ethanol. This action of ACP was also seen when the culture was exposed to 1-EBIO, a SK potassium channel opener, and was blocked by apamin, an SK channel antagonist. In contrast, ACP or Lv extracts did not reverse the suppressive effects of higher ethanol. Conclusions: Our results suggest that ACP acts by interacting with the SK channel, to block the facilitatory effect of low concentration of ethanol, on network activity in hippocampal cultures. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 1-EBIO; Acetylpectolinarin; Alcohol; Apamin; Calcium imaging; Extract; Flavonoid; Hippocampal culture; Linaria vulgaris |
| المشرفين على المادة: | 0 (Chromones) 0 (Flavonoids) 0 (Plant Extracts) 0 (Potassium Channel Blockers) 24345-16-2 (Apamin) 3K9958V90M (Ethanol) |
| تواريخ الأحداث: | Date Created: 20181006 Date Completed: 20181224 Latest Revision: 20181224 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.jep.2018.09.040 |
| PMID: | 30287194 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
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| DOI: | 10.1016/j.jep.2018.09.040 |