دورية أكاديمية
أعرض في EDS

Effects of oral probiotic supplementation on gut Lactobacillus and Bifidobacterium populations and the clinical status of low-birth-weight preterm neonates: a multicenter randomized, double-blind, placebo-controlled trial.

التفاصيل البيبلوغرافية
العنوان: Effects of oral probiotic supplementation on gut Lactobacillus and Bifidobacterium populations and the clinical status of low-birth-weight preterm neonates: a multicenter randomized, double-blind, placebo-controlled trial.
المؤلفون: Strus M; Department of Microbiology, Jagiellonian University Medical College, Kraków, Poland, piotr.heczko@pebeha.pl., Helwich E; Department of Neonatology, Institute of Mother and Child, Warszawa, Poland., Lauterbach R; Clinical Department of Neonatology, University Hospital, Kraków, Poland., Rzepecka-Węglarz B; Department of Neonatal Intensive Care, 'UJASTEK' Medical Centre, Kraków, Poland., Nowicka K; Department of Neonatology, Institute of Mother and Child, Warszawa, Poland., Wilińska M; Clinical Department of Neonatology, Independent Public Clinical Hospital CMKP, Warszawa, Poland., Szczapa J; Department of Neonatology, Gynecology and Obstetrics Clinical Hospital, Poznań, Poland., Rudnicka M; Department of Neonatology, Regional Specialist Hospital, Wrocław, Poland., Sławska H; Department of Neonatology, Specialist Hospital No. 2, Bytom, Poland., Szczepański M; Clinic Department of Neonatology and Neonatal Intensive Care, University Clinical Hospital, Białystok, Poland., Waśko A; Medical Department, IBSS BIOMED S.A., Kraków, Poland., Mikołajczyk-Cichońska A; Medical Department, IBSS BIOMED S.A., Kraków, Poland., Tomusiak-Plebanek A; Department of Microbiology, Jagiellonian University Medical College, Kraków, Poland, piotr.heczko@pebeha.pl., Heczko PB; Department of Microbiology, Jagiellonian University Medical College, Kraków, Poland, piotr.heczko@pebeha.pl.
المصدر: Infection and drug resistance [Infect Drug Resist] 2018 Sep 21; Vol. 11, pp. 1557-1571. Date of Electronic Publication: 2018 Sep 21 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Dove Medical Press Country of Publication: New Zealand NLM ID: 101550216 Publication Model: eCollection Cited Medium: Print ISSN: 1178-6973 (Print) Linking ISSN: 11786973 NLM ISO Abbreviation: Infect Drug Resist Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Auckland, N.Z. : Dove Medical Press, 2008-
مستخلص: Aim: Probiotic bacteria administered directly after birth to preterm neonates may improve gastrointestinal function and may reduce the incidence of late-onset sepsis, which is a frequent complication in this group.
Purpose: The main objective of this study was to evaluate whether a new probiotic bacterial mixture of Lactobacillus rhamnosus KL53A and Bifidobacterium breve PB04 given to preterm, low-birth-weight neonates would influence composition of their gut microbiota and sepsis rates.
Patients and Methods: This study was a multicenter, randomized, double-blind, placebo-controlled trial conducted in clinical centers of neonatal care in Poland. A probiotic or placebo preparation was given twice daily to 181 preterm low-birth-weight neonates who were eligible for enteral feeding between July 2012 and July 2013. The probiotic was given to 90 neonates, while placebo was given to 91 neonates. The gut microbiota was monitored by microbiological analysis of stool samples. Sepsis episodes were detected on the basis of clinical and laboratory findings and confirmed by blood cultures.
Results: Tested probiotic administration resulted in continuous increase of the Lactobacillus and Bifidobacterium counts in the gut microbiota. The applied tested strains successfully colonized the neonates gut since they were present in over 90% of stool samples, which was confirmed by molecular analysis. Regardless of the study group (probiotic or placebo), B. breve colonization correlated with lower staphylococcal sepsis incidence, which was irrespective of whether probiotics were given. No sepsis case caused by strains included in study probiotic was recorded.
Conclusion: Appropriately selected and characterized probiotic bacteria may be safely given to preterm neonates to normalize their distorted gut microbiota and may contribute to lower staphylococcal sepsis rates.
Competing Interests: Disclosure The authors report no conflicts of interest in this work.
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فهرسة مساهمة: Keywords: Bifidobacterium; LBW neonates; Lactobacillus; gut microbiota; probiotics; staphylococcal sepsis
تواريخ الأحداث: Date Created: 20181006 Latest Revision: 20220321
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6160268
DOI: 10.2147/IDR.S166348
PMID: 30288066
قاعدة البيانات: MEDLINE
الوصف
تدمد:1178-6973
DOI:10.2147/IDR.S166348