دورية أكاديمية
Biological Actions, Electrical Conductance and Silicon-Containing Microparticles of Arsenicum Album Prepared in Plastic and Glass Vials.
| العنوان: | Biological Actions, Electrical Conductance and Silicon-Containing Microparticles of Arsenicum Album Prepared in Plastic and Glass Vials. |
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| المؤلفون: | Dalboni LC; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Coelho CP; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil.; Graduating Program of Animal Medicine and Welfare, Universidade de Santo Amaro - UNISA, São Paulo, São Paulo, Brazil., Palombo Pedro RR; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Correia MS; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., de Santana FR; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Cardoso TN; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Pinto SAG; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Alvares-Saraiva AM; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Dutra-Correa M; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Peres GB; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil., Holandino C; Faculty of Pharmacy, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil., Rossi A; Faculty of Pharmacy, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil., César AT; Farmácia HN Cristiano, São Paulo, São Paulo, Brazil., Waisse S; Graduating Program of History of Science, Pontifícia Universidade Católica de São Paulo, São Paulo, São Paulo, Brazil., Bonamin LV; Research Center, Graduating Program of Environmental and Experimental Pathology, Universidade Paulista - UNIP, São Paulo, São Paulo, Brazil. |
| المصدر: | Homeopathy : the journal of the Faculty of Homeopathy [Homeopathy] 2019 Feb; Vol. 108 (1), pp. 12-23. Date of Electronic Publication: 2018 Oct 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 101140517 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4245 (Electronic) Linking ISSN: 14754916 NLM ISO Abbreviation: Homeopathy Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart, Germany : Thieme Original Publication: Edinburgh : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | Electric Conductivity*, Arsenicals/*isolation & purification , Silicon/*isolation & purification, Cytokines/isolation & purification ; Homeopathy/methods ; Humans ; Microscopy, Electron, Scanning/methods |
| مستخلص: | Introduction: According to the "silica hypothesis" formulated to explain homeopathy, the information of starting materials would be transferred to cells by silica nanoparticles detached from the glassware walls by serial dilution and agitation through epitaxy. We compared the biological activity, electrical current and silicon microparticle content (by means of scanning electron microscopy/energy-dispersive X-ray spectroscopy) of high dilutions (HDs) of arsenic prepared in plastic and glass vials to investigate the role of silica in their biological effects in vitro. Materials and Methods: Co-cultures of macrophages and yeast ( Saccharomyces cerevisiae ) were treated with different HDs of arsenic prepared in plastic and glass vials. Macrophage morphology, phagocytosis index, nitric oxide (NO), and cytokine production were evaluated. Results: Measurable amounts of silicon microparticles were detected only in the HDs prepared in glass vials, but ultra-centrifugation eliminated them. Specific and non-specific results were observed. Non-specific pro-inflammatory effects were seen in all dilutions prepared in plastic vials, including elevation of pro-inflammatory cytokines, NO and macrophage phagocytic index. Only the 200th centesimal dilution of arsenic produced specific decrease in interleukin-6 production in macrophages, and it was independent of the vial type or the presence of microparticles of silica in the medicine samples. The nature of the vials had an impact on the electric flow in the respective fluids. Conclusion: The non-specific, pro-inflammatory effects might be attributed to organic residuals detached from the vials' plastic walls during manipulation. Instead, specific silica-independent effects of the homeopathic medicine can be attributed to the decrease of interleukin-6 after treatment with the 200th centesimal dilution of arsenic. Competing Interests: The authors declare there is no conflict of interest. Funding sponsors did not interfere with the design of the study, collection, analysis or interpretation of data, manuscript writing, or with the decision to publish the results. The initial project was selected for ABFH grant after ad hoc and blind evaluation of the proposal. (The Faculty of Homeopathy.) |
| المشرفين على المادة: | 0 (Arsenicals) 0 (Arsenicum Album-200) 0 (Cytokines) Z4152N8IUI (Silicon) |
| تواريخ الأحداث: | Date Created: 20181006 Date Completed: 20190930 Latest Revision: 20190930 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1055/s-0038-1670675 |
| PMID: | 30290377 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-4245 |
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| DOI: | 10.1055/s-0038-1670675 |