دورية أكاديمية
Quantification of Activity Lost to Delivery-System Residual and Decay in Yttrium-90 Radioembolization.
| العنوان: | Quantification of Activity Lost to Delivery-System Residual and Decay in Yttrium-90 Radioembolization. |
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| المؤلفون: | Hoang NS; Division of Interventional Radiology, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305., Khalaf MH; Division of Interventional Radiology, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305., Rosenberg JK; Department of Radiology, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305., Kwofie J; Health Physics Group, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305., Reposar AL; Division of Interventional Radiology, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305., Wang DS; Division of Interventional Radiology, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305., Louie JD; Division of Interventional Radiology, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305., Sze DY; Division of Interventional Radiology, Stanford University School of Medicine, H3646 Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305. Electronic address: dansze@stanford.edu. |
| المصدر: | Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2018 Dec; Vol. 29 (12), pp. 1672-1677. Date of Electronic Publication: 2018 Oct 11. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Society of Cardiovascular and Interventional Radiology Country of Publication: United States NLM ID: 9203369 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-7732 (Electronic) Linking ISSN: 10510443 NLM ISO Abbreviation: J Vasc Interv Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Reston, Va. : Society of Cardiovascular and Interventional Radiology, c1990- |
| مواضيع طبية MeSH: | Glass* , Radiotherapy Dosage*, Embolization, Therapeutic/*methods , Radiopharmaceuticals/*administration & dosage , Yttrium Radioisotopes/*administration & dosage, Humans ; Microspheres ; Retrospective Studies |
| مستخلص: | Purpose: To measure the decay activity loss and delivery system residual activity loss of yttrium-90 (Y 90 ) radioembolization treatments across resin and glass microsphere activities. Materials and Methods: For Y 90 administrations between December 2009 and June 2017 at the study institution, the prescribed activity, prepared activity, and delivered activity were recorded. Six hundred sixty-two administrations were reviewed-345 glass (0.21-8.52 GBq) and 317 resin (0.18-3.28 GBq). Twenty-five patients (all resin) were excluded for arterial stasis or catheter clogging. The percentage and actual losses of activity lost to decay and to delivery system residual were calculated for glass and resin microspheres. Results: The median time between activity premeasurement and administration was 2.20 hours, resulting in a median activity lost to decay of 0.030 GBq or 2.35%, with no significant difference observed between glass and resin despite differences in preparation (P = .0697). Resin showed significantly higher activity lost to delivery system residual than glass (0.039 GBq vs 0.010 GBq, 3.01% vs 0.61%, P < .001). The percent activity lost to residual varied with activity prepared, with a maximum of 20.1% and 16.2% for the smallest activities of resin and glass, respectively. Conclusions: Residual activity loss differs between glass and resin microspheres. For resin microspheres in particular, percent residual activity loss increases with lower prepared activities. Protocols for activity calculation and preparation, patient dosimetry, and regulatory compliance must take these losses into consideration prospectively. (Copyright © 2018 SIR. Published by Elsevier Inc. All rights reserved.) |
| المشرفين على المادة: | 0 (Radiopharmaceuticals) 0 (Yttrium Radioisotopes) 1K8M7UR6O1 (Yttrium-90) |
| تواريخ الأحداث: | Date Created: 20181015 Date Completed: 20190409 Latest Revision: 20190409 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1016/j.jvir.2018.07.011 |
| PMID: | 30316674 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1535-7732 |
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| DOI: | 10.1016/j.jvir.2018.07.011 |