دورية أكاديمية
Management of recurrent implantation failure by gonadotropin-releasing hormone agonist and aromatase inhibitor suppression, in women without evidence of endometriosis.
| العنوان: | Management of recurrent implantation failure by gonadotropin-releasing hormone agonist and aromatase inhibitor suppression, in women without evidence of endometriosis. |
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| المؤلفون: | Khayat S; a Department of Obstetrics and Gynecology , McGill University, Royal Victoria Hospital , GLEN Campus , Montréal , Canada.; b Department of Obstetrics and Gynecology, King Abdulaziz University , Jeddah , Saudi Arabia., Elliott B; c Faculty of Medicine, McGill University , Montreal , Canada., Dahan MH; b Department of Obstetrics and Gynecology, King Abdulaziz University , Jeddah , Saudi Arabia. |
| المصدر: | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2019 Mar; Vol. 35 (3), pp. 267-270. Date of Electronic Publication: 2018 Oct 17. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8807913 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-0766 (Electronic) Linking ISSN: 09513590 NLM ISO Abbreviation: Gynecol Endocrinol |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Carnforth, Lancashire ; Park Ridge, N.J.] : Parthenon Pub., [c1987- |
| مواضيع طبية MeSH: | Embryo Transfer*, Embryo Implantation/*drug effects , Fertility Agents, Female/*therapeutic use , Gonadotropin-Releasing Hormone/*agonists , Letrozole/*therapeutic use , Leuprolide/*therapeutic use, Adult ; Aromatase Inhibitors/administration & dosage ; Aromatase Inhibitors/therapeutic use ; Female ; Fertility Agents, Female/administration & dosage ; Fertilization in Vitro ; Humans ; Letrozole/administration & dosage ; Leuprolide/administration & dosage ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Retreatment ; Retrospective Studies ; Treatment Failure |
| مستخلص: | Endometriosis is common among those with infertility, although many cases go undiagnosed. This study was performed to determine whether empiric treatment with two months of depo-leuprolide 3.75 mg monthly (dep-GnRH-ag) and letrozole 5 mg daily improves pregnancy outcomes in patients with at least two unexplained failed embryo transfers (ETs) but without a previous diagnosis of endometriosis. A retrospective cohort study was performed with subjects who failed at least two good quality ET. The study excluded women with a known history of endometriosis or ovarian cysts (possible endometriomas). Subjects (N = 38) were treated with dep-GnRH-ag and letrozole pre-cycle. Matched women (N = 37) who did not receive either pretreatment served as a control group. Data were compared by non-paired T-tests and multivariate logistic regression to control for confounding effects. Demographic data, hormonal profiles, and ovarian reserve parameters were similar between the two groups. The treated group had failed more embryo transfers (3.5 ± 1.7 vs. 2.0 ± 1.3, p = .01) than the controls. When adjusting for the number of MII oocytes collected, number of blastocysts developed and number of blastocysts transferred, there were more pregnancies (24/38 vs. 11/37, p = .02) and ongoing pregnancies (18/38 vs. 9/37, p = .03) in the treated group. Patients with multiple unexplained failed ET may have undiagnosed endometriosis and may benefit from pretreatment with dep-GnRH-ag and letrozole. These results would benefit from being subjected to a randomized prospective study. |
| فهرسة مساهمة: | Keywords: Infertility; aromatase inhibitor; endometriosis; gonadotropin-releasing hormone agonist; repetitive failed embryo transfers |
| المشرفين على المادة: | 0 (Aromatase Inhibitors) 0 (Fertility Agents, Female) 33515-09-2 (Gonadotropin-Releasing Hormone) 7LKK855W8I (Letrozole) EFY6W0M8TG (Leuprolide) |
| تواريخ الأحداث: | Date Created: 20181018 Date Completed: 20190726 Latest Revision: 20190726 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/09513590.2018.1519790 |
| PMID: | 30328740 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1473-0766 |
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| DOI: | 10.1080/09513590.2018.1519790 |