Preoperative Oral Pregabalin Reduces Acute Pain after Thoracotomy.

التفاصيل البيبلوغرافية
العنوان:	Preoperative Oral Pregabalin Reduces Acute Pain after Thoracotomy.
المؤلفون:	Sattari H; Department of Anesthesiology and Pain Medicine, Kerman University of Medical Sciences, Iran., Hashemian M; Department of Anesthesiology and Pain Medicine, Kerman University of Medical Sciences, Iran., Lashkarizadeh MR; Department of Thoracic surgery, Afzalipoor Hospital, Kerman University of Medical Sciences, Iran., Jalalifard H; Department of Anesthesia, Afzalipoor Hospital, Kerman University of Medical Sciences, Iran.
المصدر:	Open access Macedonian journal of medical sciences [Open Access Maced J Med Sci] 2018 Sep 18; Vol. 6 (9), pp. 1606-1610. Date of Electronic Publication: 2018 Sep 18 (Print Publication: 2018).
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Scientific Foundation SPIROSKI Country of Publication: North Macedonia NLM ID: 101662294 Publication Model: eCollection Cited Medium: Print ISSN: 1857-9655 (Print) Linking ISSN: 18579655 NLM ISO Abbreviation: Open Access Maced J Med Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Publication: Skopje, Republic of Macedonia : Scientific Foundation SPIROSKI Original Publication: Skopje, Republic of Macedonia : ID Design Press, [2013]-
مستخلص:	Background: Nowadays pain control is one of the most important challenges for physicians, surgeons and anesthesiologists. New drugs and procedures to control pain have always been a major topic for researches. Aim: In this study, we evaluated the effects of preoperative pregabalin administration on relieving postoperative pain after thoracotomy surgery. Materials and Methods: This study is a randomised, double-blind clinical trial, performed on 60 patients who underwent thoracotomy at Afzalipour hospital in Kerman, Iran. They were divided into case and control groups. Two hours before surgery an oral capsule of 300 mg pregabalin or placebo was given to patients. All patients similarly underwent general anaesthesia. Pain, nausea and vomiting were evaluated based on the visual analogue scale (VAS) and frequency. This study was verified and obtained the ethics committee code of K/92/489 from Kerman University of Medical Sciences. Results: The average age of the pregabalin group was 39.7 ± 5.8 years and the control group 41.3 ± 6.1 years. The average pain score after regaining consciousness was 6.1 ± 0.2 in the case group and 7.9 ± 0.1 in the control group, and there was a significant difference between the 2 groups (p-value = 0.002). In the control group, 2 patients and the intervention group 3 patients, experienced nausea and vomiting. There was a significant difference between the overall average pethidine consumption and the average visual analogue scale in both groups. Conclusion: Pregabalin administration before thoracotomy is effective to reduce postoperative pain in patients. More research is needed to determine the optimal dose of pregabalin for preoperative administration.
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فهرسة مساهمة:	Keywords: Clinical trial; Post-operative pain; Pregabalin; Thoracotomy; VAS
تواريخ الأحداث:	Date Created: 20181020 Latest Revision: 20200929
رمز التحديث:	20240628
مُعرف محوري في PubMed:	PMC6182520
DOI:	10.3889/oamjms.2018.334
PMID:	30337973
قاعدة البيانات:	MEDLINE

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تدمد:	1857-9655
DOI:	10.3889/oamjms.2018.334