دورية أكاديمية
Evolutionary origin of 2A-like sequences in Totiviridae genomes.
| العنوان: | Evolutionary origin of 2A-like sequences in Totiviridae genomes. |
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| المؤلفون: | de Lima JGS; Applied Molecular Biology Lab - LAPLIC, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Teixeira DG; Laboratory of Metabolic Systems and Bioinformatics - LASIS, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Freitas TT; Applied Molecular Biology Lab - LAPLIC, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Science, Technology and Innovation, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Lima JPMS; Laboratory of Metabolic Systems and Bioinformatics - LASIS, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil., Lanza DCF; Applied Molecular Biology Lab - LAPLIC, Department of Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Biochemistry, Federal University of Rio Grande do Norte, Natal, RN, Brazil; Postgraduate Program in Science, Technology and Innovation, Federal University of Rio Grande do Norte, Natal, RN, Brazil. Electronic address: danielclanza@gmail.com. |
| المصدر: | Virus research [Virus Res] 2019 Jan 02; Vol. 259, pp. 1-9. Date of Electronic Publication: 2018 Oct 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8410979 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7492 (Electronic) Linking ISSN: 01681702 NLM ISO Abbreviation: Virus Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science, c1984- |
| مواضيع طبية MeSH: | Evolution, Molecular* , Genome, Viral* , Genomics*, Oligonucleotides/*genetics , Totiviridae/*classification , Totiviridae/*genetics, Amino Acid Sequence ; Computational Biology/methods ; Oligonucleotides/chemistry ; Phylogeny ; Sequence Analysis, DNA |
| مستخلص: | In recent years there has been a significant increase in the number of new species potentially belonging to the Totiviridae family. Most of these new viruses have not yet been covered by the Committee on Taxonomy of Viruses (ICTV) official classification. In this study, a phylogenetic analysis including new sequences of Totiviridae candidates revealed a clade including Giardiavirus and a great diversity of new totiviruses, which infect arthropods, protozoa and mollusc. This expanded Giardiavirus clade comprises two monophyletic groups, one of them including Giardia lamblia virus (GLV) grouped with viruses that infect arthropods and vertebrates (GLV-like group), and the other includes the previously proposed Artivirus group (IMNV-like group). A screening of the members of the GLV-like group in search of genomic elements already described in IMNV-like group revealed the existence of sites with a high propensity to become 2 A-like oligopeptides, mainly in a specific subgroup of arthropod viruses, suggesting that these viruses preserved ancestral characteristics. The existence of these "pseudo 2 A-sites" associated to phylogenetic reconstruction indicates that these sequences appear at a decisive stage for viral evolution. If they are changed to functional 2 A-like sequences, an irreversible route to increase the genome complexity will be initiated. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 2A-like ranking; Arthropod totivirus; Artivirus; Giardiavirus; IMNV; Pseudo 2A-site |
| المشرفين على المادة: | 0 (Oligonucleotides) |
| تواريخ الأحداث: | Date Created: 20181020 Date Completed: 20190110 Latest Revision: 20190110 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.virusres.2018.10.011 |
| PMID: | 30339789 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7492 |
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| DOI: | 10.1016/j.virusres.2018.10.011 |