دورية أكاديمية
Biomarkers for Barrett's esophagus - a contemporary review.
| العنوان: | Biomarkers for Barrett's esophagus - a contemporary review. |
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| المؤلفون: | Qureshi AP; a Beth Israel Deaconess Medical Center, Department of Surgery , Harvard Medical School , Boston , MA., Stachler MD; b Department of Pathology, Harvard Medical School , Brigham and Women's Hospital , Boston , MA., Haque O; a Beth Israel Deaconess Medical Center, Department of Surgery , Harvard Medical School , Boston , MA., Odze RD; b Department of Pathology, Harvard Medical School , Brigham and Women's Hospital , Boston , MA. |
| المصدر: | Expert review of molecular diagnostics [Expert Rev Mol Diagn] 2018 Nov; Vol. 18 (11), pp. 939-946. Date of Electronic Publication: 2018 Nov 01. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 101120777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8352 (Electronic) Linking ISSN: 14737159 NLM ISO Abbreviation: Expert Rev Mol Diagn Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Taylor & Francis Original Publication: London : Future Drugs Ltd, 2001- |
| مواضيع طبية MeSH: | Barrett Esophagus/*genetics, Barrett Esophagus/metabolism ; Barrett Esophagus/pathology ; Biomarkers/analysis ; Epigenesis, Genetic ; Genomic Instability ; Humans |
| مستخلص: | Introduction: Esophageal adenocarcinoma (EAC) has a poor 5-year survival rate (10%-18%), and incidence has increased dramatically in the past three decades. Barrett's esophagus (BE) is the precursor lesion to EAC and is the replacement of the normally squamous lined esophagus with columnar cells that develop an intestinal phenotype characterized by the presence of goblet cells. Given the known precursor state, EAC is amenable to screening and surveillance strategies (analogous to colon cancer). However, unlike from colon cancer screening, BE poses challenges that make effective screening difficult. Robust and concerted effort is under way to find biomarkers of BE. Areas covered: This review summarizes current known biomarkers for BE. These include dysplasia, genomic markers, and gene expression alterations that occur early in the dysplasia/carcinoma sequence. Expert commentary: Despite the tremendous breadth of work in studying molecular advances, the ideal biomarker for BE has not yet been discerned. This review comments on innovations in the field of BE research that combine state-of-the-art molecular advances with simple technologies. |
| فهرسة مساهمة: | Keywords: Barrett’s esophagus; biomarkers; dysplasia/carcinoma sequence; esophageal adenocarcinoma; gene expression; high grade dysplasia |
| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20181023 Date Completed: 20190529 Latest Revision: 20190529 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/14737159.2018.1538793 |
| PMID: | 30345836 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-8352 |
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| DOI: | 10.1080/14737159.2018.1538793 |