دورية أكاديمية
Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide.
| العنوان: | Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide. |
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| المؤلفون: | Jackman JA; School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore., Costa VV; Immunopharmacology Lab, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.; Center for Drug Research and Development of Pharmaceuticals, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.; Research Group in Arboviral Diseases, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil., Park S; School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore., Real ALCV; Neurobiochemistry Lab, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil., Park JH; School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore., Cardozo PL; Neurobiochemistry Lab, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil., Ferhan AR; School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore., Olmo IG; Neurobiochemistry Lab, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil., Moreira TP; Research Group in Arboviral Diseases, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.; Host-Interaction Microorganism Lab, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Bambirra JL; Research Group in Arboviral Diseases, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.; Host-Interaction Microorganism Lab, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Queiroz VF; Research Group in Arboviral Diseases, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.; Host-Interaction Microorganism Lab, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Queiroz-Junior CM; Cardiac Biology Lab, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Foureaux G; Cardiac Biology Lab, Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Souza DG; Host-Interaction Microorganism Lab, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Ribeiro FM; Neurobiochemistry Lab, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil., Yoon BK; School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore., Wynendaele E; Drug Quality and Registration Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., De Spiegeleer B; Drug Quality and Registration Group, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium., Teixeira MM; Immunopharmacology Lab, Department of Biochemistry and Immunology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.; Center for Drug Research and Development of Pharmaceuticals, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Minas Gerais, Brazil., Cho NJ; School of Materials Science and Engineering, Nanyang Technological University, Singapore, Singapore. njcho@ntu.edu.sg.; School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore. njcho@ntu.edu.sg. |
| المصدر: | Nature materials [Nat Mater] 2018 Nov; Vol. 17 (11), pp. 971-977. Date of Electronic Publication: 2018 Oct 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101155473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4660 (Electronic) Linking ISSN: 14761122 NLM ISO Abbreviation: Nat Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London, UK : Nature Pub. Group, [2002]- |
| مواضيع طبية MeSH: | Antiviral Agents/*therapeutic use , Brain/*metabolism , Peptides/*therapeutic use , Zika Virus Infection/*drug therapy, Animals ; Antiviral Agents/pharmacokinetics ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Peptides/pharmacokinetics |
| مستخلص: | Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including Guillain-Barré syndrome 1 and congenital Zika syndrome 2 . As Zika virus targets the nervous system, there is an urgent need to develop therapeutic strategies that inhibit Zika virus infection in the brain. Here, we have engineered a brain-penetrating peptide that works against Zika virus and other mosquito-borne viruses. We evaluated the therapeutic efficacy of the peptide in a lethal Zika virus mouse model exhibiting systemic and brain infection. Therapeutic treatment protected against mortality and markedly reduced clinical symptoms, viral loads and neuroinflammation, as well as mitigated microgliosis, neurodegeneration and brain damage. In addition to controlling systemic infection, the peptide crossed the blood-brain barrier to reduce viral loads in the brain and protected against Zika-virus-induced blood-brain barrier injury. Our findings demonstrate how engineering strategies can be applied to develop peptide therapeutics and support the potential of a brain-penetrating peptide to treat neurotropic viral infections. |
| التعليقات: | Comment in: Nat Mater. 2018 Nov;17(11):955-956. (PMID: 30353084) |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (Peptides) |
| تواريخ الأحداث: | Date Created: 20181024 Date Completed: 20190522 Latest Revision: 20190827 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1038/s41563-018-0194-2 |
| PMID: | 30349030 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1476-4660 |
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| DOI: | 10.1038/s41563-018-0194-2 |