دورية أكاديمية
Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton.
| العنوان: | Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton. |
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| المؤلفون: | Maridas DE; Maine Medical Center Research Institute, Scarborough, Maine, USA.; Harvard School of Dental Medicine, Boston, Massachusetts, USA; and., Rendina-Ruedy E; Maine Medical Center Research Institute, Scarborough, Maine, USA., Helderman RC; Maine Medical Center Research Institute, Scarborough, Maine, USA., DeMambro VE; Maine Medical Center Research Institute, Scarborough, Maine, USA., Brooks D; Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Guntur AR; Maine Medical Center Research Institute, Scarborough, Maine, USA., Lanske B; Harvard School of Dental Medicine, Boston, Massachusetts, USA; and., Bouxsein ML; Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA., Rosen CJ; Maine Medical Center Research Institute, Scarborough, Maine, USA. |
| المصدر: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Feb; Vol. 33 (2), pp. 2885-2898. Date of Electronic Publication: 2018 Oct 24. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley Original Publication: [Bethesda, Md.] : The Federation, [c1987- |
| مواضيع طبية MeSH: | Adipocytes/*cytology , Bone Resorption/*drug therapy , Lipolysis/*drug effects , Mesenchymal Stem Cells/*cytology , Osteoblasts/*cytology , Parathyroid Hormone/*pharmacology , Stem Cells/*cytology, Adipocytes/drug effects ; Adipocytes/metabolism ; Adipogenesis ; Animals ; Bone Resorption/metabolism ; Bone Resorption/pathology ; Caloric Restriction ; Cell Differentiation ; Cells, Cultured ; Female ; Mesenchymal Stem Cells/drug effects ; Mesenchymal Stem Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteogenesis ; Stem Cells/drug effects ; Stem Cells/metabolism |
| مستخلص: | Intermittent administration of parathyroid hormone (PTH) stimulates bone formation in vivo and also suppresses the volume of bone marrow adipose tissue (BMAT). In contrast, a calorie-restricted (CR) diet causes bone loss and induces BMAT in both mice and humans. We used the CR model to test whether PTH would reduce BMAT in mice by both altering cell fate and inducing lipolysis of marrow adipocytes. Eight-week-old mice were placed on a control (Ctrl) diet or CR diet. At 12 wk, CR and Ctrl mice were injected daily with PTH (CR/PTH or Ctrl/PTH) or vehicle for 4 wk. Two other cohorts were CR and simultaneously injected (CR + PTH or CR + Veh) for 4 wk. CR mice had low bone mass and increased BMAT in the proximal tibias. PTH significantly increased bone mass in all cohorts despite calorie restrictions. Adipocyte density and size were markedly increased with restriction of calories. PTH reduced adipocyte numbers in CR + PTH mice, whereas adipocyte size was reduced in CR/PTH-treated mice. In contrast, osteoblast number was increased 3-8-fold with PTH treatment. In vitro, bone marrow stromal cells differentiated into adipocytes and, treated with PTH, exhibited increased production of glycerol and fatty acids. Moreover, in cocultures of bone marrow adipocyte and osteoblast progenitors, PTH stimulated the transfer of fatty acids to osteoblasts. In summary, PTH administration to CR mice increased bone mass by shifting lineage allocation toward osteogenesis and inducing lipolysis of mature marrow adipocytes. The effects of PTH on bone marrow adiposity could enhance its anabolic actions by providing both more cells and more fuel for osteoblasts during bone formation.-Maridas, D. E., Rendina-Ruedy, E., Helderman, R. C., DeMambro, V. E., Brooks, D., Guntur, A. R., Lanske, B., Bouxsein, M. L., Rosen, C. J. Progenitor recruitment and adipogenic lipolysis contribute to the anabolic actions of parathyroid hormone on the skeleton. |
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| معلومات مُعتمدة: | P30 GM106391 United States GM NIGMS NIH HHS; R24 DK092759 United States DK NIDDK NIH HHS; R01 DK112374 United States DK NIDDK NIH HHS; R56 DK112374 United States DK NIDDK NIH HHS; U54 GM115516 United States GM NIGMS NIH HHS; P20 GM121301 United States GM NIGMS NIH HHS; K01 AR072123 United States AR NIAMS NIH HHS |
| فهرسة مساهمة: | Keywords: PTH; adipocytes; bone; fat; marrow |
| المشرفين على المادة: | 0 (Parathyroid Hormone) |
| تواريخ الأحداث: | Date Created: 20181026 Date Completed: 20190930 Latest Revision: 20240922 |
| رمز التحديث: | 20240922 |
| مُعرف محوري في PubMed: | PMC6338651 |
| DOI: | 10.1096/fj.201800948RR |
| PMID: | 30354669 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1530-6860 |
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| DOI: | 10.1096/fj.201800948RR |