دورية أكاديمية
أعرض في EDS

Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea.

التفاصيل البيبلوغرافية
العنوان: Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea.
المؤلفون: Ganesh BP; From the Department of Neurology, University of Texas Health Sciences Center, Houston (B.P.G.)., Nelson JW; Department of Anesthesiology, Baylor College of Medicine, Houston TX (J.W.N., A.G., R.M.B., D.J.D.)., Eskew JR; Mercer University School of Medicine, Macon, GA (J.R.E.)., Ganesan A; Department of Anesthesiology, Baylor College of Medicine, Houston TX (J.W.N., A.G., R.M.B., D.J.D.)., Ajami NJ; Department of Molecular Virology and Microbiology, The Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston TX (N.J.A., J.F.P.)., Petrosino JF; Department of Molecular Virology and Microbiology, The Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston TX (N.J.A., J.F.P.)., Bryan RM Jr; Department of Anesthesiology, Baylor College of Medicine, Houston TX (J.W.N., A.G., R.M.B., D.J.D.).; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston TX (R.M.B., D.J.D.)., Durgan DJ; Department of Anesthesiology, Baylor College of Medicine, Houston TX (J.W.N., A.G., R.M.B., D.J.D.).; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston TX (R.M.B., D.J.D.).
المصدر: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2018 Nov; Vol. 72 (5), pp. 1141-1150.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
أسماء مطبوعة: Publication: : Hagerstown, MD : Lippincott, Williams & Wilkins
Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]-
مواضيع طبية MeSH: Prebiotics* , Probiotics*, Acetates/*therapeutic use , Hypertension/*prevention & control , Sleep Apnea, Obstructive/*complications, Animals ; Blood Pressure/physiology ; Disease Models, Animal ; Gastrointestinal Microbiome/physiology ; Hypertension/complications ; Male ; Rats ; Rats, Long-Evans
مستخلص: Disruption of the gut microbiota, termed gut dysbiosis, has been described in animal models of hypertension and hypertensive patients. We have shown that gut dysbiosis plays a causal role in the development of hypertension in a rat model of obstructive sleep apnea (OSA). Functional analysis of the dysbiotic microbiota in OSA demonstrates a loss of short chain fatty acid-producing bacteria. However, measurements of short chain fatty acid concentrations and testing of their role in blood pressure regulation are lacking. We hypothesized that reduced short chain fatty acids in the gut are responsible for OSA-induced hypertension. OSA significantly increased systolic blood pressure at 7 and 14 days ( P<0.05), an effect that was abolished by the probiotic Clostridium butyricum or the prebiotic Hylon VII. The 16S rRNA analysis identified several short chain fatty acid-producing bacteria that were significantly increased by Cbutyricum and Hylon treatment. Acetate concentration in the cecum was decreased by 48% after OSA ( P<0.05), an effect that was prevented by Cbutyricum and Hylon. Cbutyricum and Hylon reduced OSA-induced dysbiosis, epithelial goblet cell loss, mucus barrier thinning, and activation of brain microglia ( P<0.05 for each). To examine the role of acetate in OSA-induced hypertension, we chronically infused acetate into the cecum during 2 weeks of sham or OSA. Restoring cecal acetate concentration prevented OSA-induced gut inflammation and hypertension ( P<0.05). These studies identify acetate as a key player in OSA-induced hypertension. We demonstrate that various methods to increase cecal acetate concentrations are protective from the adverse effects of OSA on the microbiota, gut, brain, and blood pressure.
التعليقات: Comment in: Hypertension. 2018 Nov;72(5):1078-1080. (PMID: 30354835)
References: PLoS One. 2014 Oct 23;9(10):e111053. (PMID: 25340336)
Adv Immunol. 2014;121:91-119. (PMID: 24388214)
Gut Microbes. 2014 Mar-Apr;5(2):202-7. (PMID: 24429443)
Nutrients. 2015 Apr 14;7(4):2839-49. (PMID: 25875123)
Neurobiol Aging. 2017 Jan;49:60-68. (PMID: 27776263)
J Biol Chem. 2015 Feb 27;290(9):5647-60. (PMID: 25550161)
Sleep. 2015 Oct 01;38(10):1537-46. (PMID: 26085297)
Ann Neurol. 2018 Jul;84(1):23-36. (PMID: 29733457)
Nat Chem Biol. 2014 Jun;10(6):416-24. (PMID: 24838170)
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):4410-5. (PMID: 23401498)
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10719-10724. (PMID: 28893994)
Hypertension. 2015 Jun;65(6):1331-40. (PMID: 25870193)
Physiol Genomics. 2015 Jun;47(6):187-97. (PMID: 25829393)
Nat Commun. 2016 Jun 28;7:12015. (PMID: 27352007)
Physiol Genomics. 2016 Nov 1;48(11):826-834. (PMID: 27664183)
Microbiome. 2017 Feb 1;5(1):14. (PMID: 28143587)
Nutr Metab (Lond). 2009 Mar 07;6:11. (PMID: 19267935)
Physiol Genomics. 2017 Feb 1;49(2):96-104. (PMID: 28011881)
BMJ. 2014 Jul 29;349:g4490. (PMID: 25073782)
J Hypertens. 2005 Mar;23(3):475-81. (PMID: 15716684)
Curr Hypertens Rep. 2017 Apr;19(4):35. (PMID: 28365886)
Annu Rev Physiol. 2016;78:391-414. (PMID: 26667077)
Best Pract Res Clin Gastroenterol. 2013 Feb;27(1):73-83. (PMID: 23768554)
Hypertension. 2016 Feb;67(2):469-74. (PMID: 26711739)
Cell Metab. 2016 Jun 14;23(6):1216-1223. (PMID: 27304513)
J Neuroinflammation. 2015 May 03;12:85. (PMID: 25935397)
Curr Opin Nephrol Hypertens. 2014 Sep;23(5):507-12. (PMID: 25023949)
Gut. 2014 Jan;63(1):116-24. (PMID: 23598352)
Arch Intern Med. 2005 Jan 24;165(2):150-6. (PMID: 15668359)
Circ Res. 2017 Jan 20;120(2):312-323. (PMID: 27799253)
Circ Res. 2015 Jul 3;117(2):178-91. (PMID: 25963715)
Nat Med. 2016 May;22(5):516-23. (PMID: 27019327)
J Clin Invest. 2014 Oct;124(10):4204-11. (PMID: 25271725)
J Neurosci. 2016 Jul 13;36(28):7428-40. (PMID: 27413153)
J Alzheimers Dis. 2017;56(2):775-788. (PMID: 28035935)
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71. (PMID: 23671105)
Circulation. 2017 Mar 7;135(10):964-977. (PMID: 27927713)
معلومات مُعتمدة: P30 DK056338 United States DK NIDDK NIH HHS; R01 HL134838 United States HL NHLBI NIH HHS; R01 NS080531 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: acetates; blood pressure; cecum; dysbiosis; hypertension; microbiota; obstructive sleep apnea
المشرفين على المادة: 0 (Acetates)
0 (Prebiotics)
تواريخ الأحداث: Date Created: 20181026 Date Completed: 20190513 Latest Revision: 20220408
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6209125
DOI: 10.1161/HYPERTENSIONAHA.118.11695
PMID: 30354816
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4563
DOI:10.1161/HYPERTENSIONAHA.118.11695