دورية أكاديمية
A gut microbial factor modulates locomotor behaviour in Drosophila.
| العنوان: | A gut microbial factor modulates locomotor behaviour in Drosophila. |
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| المؤلفون: | Schretter CE; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. cschrett@caltech.edu., Vielmetter J; Protein Expression Center, Beckman Institute, California Institute of Technology, Pasadena, CA, USA., Bartos I; Department of Physics, Columbia University, New York, NY, USA., Marka Z; Department of Physics, Columbia University, New York, NY, USA., Marka S; Department of Physics, Columbia University, New York, NY, USA., Argade S; GlycoAnalytics Core, University of California, San Diego, CA, USA., Mazmanian SK; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. sarkis@caltech.edu. |
| المصدر: | Nature [Nature] 2018 Nov; Vol. 563 (7731), pp. 402-406. Date of Electronic Publication: 2018 Oct 24. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basingstoke : Nature Publishing Group Original Publication: London, Macmillan Journals ltd. |
| مواضيع طبية MeSH: | Carbohydrate Metabolism*/drug effects, Drosophila melanogaster/*microbiology , Drosophila melanogaster/*physiology , Gastrointestinal Microbiome/*physiology , Levilactobacillus brevis/*enzymology , Levilactobacillus brevis/*metabolism , Locomotion/*physiology, Aldose-Ketose Isomerases/metabolism ; Animals ; Anti-Bacterial Agents/pharmacology ; Drosophila melanogaster/drug effects ; Drosophila melanogaster/metabolism ; Female ; Gastrointestinal Microbiome/drug effects ; Germ-Free Life ; Levilactobacillus brevis/isolation & purification ; Locomotion/drug effects ; Motor Activity/drug effects ; Motor Activity/physiology ; Neural Pathways ; Neurons/drug effects ; Neurons/metabolism ; Octopamine/metabolism ; Octopamine/pharmacology ; Symbiosis |
| مستخلص: | While research into the biology of animal behaviour has primarily focused on the central nervous system, cues from peripheral tissues and the environment have been implicated in brain development and function 1 . There is emerging evidence that bidirectional communication between the gut and the brain affects behaviours including anxiety, cognition, nociception and social interaction 1-9 . Coordinated locomotor behaviour is critical for the survival and propagation of animals, and is regulated by internal and external sensory inputs 10,11 . However, little is known about how the gut microbiome influences host locomotion, or the molecular and cellular mechanisms involved. Here we report that germ-free status or antibiotic treatment results in hyperactive locomotor behaviour in the fruit fly Drosophila melanogaster. Increased walking speed and daily activity in the absence of a gut microbiome are rescued by mono-colonization with specific bacteria, including the fly commensal Lactobacillus brevis. The bacterial enzyme xylose isomerase from L. brevis recapitulates the locomotor effects of microbial colonization by modulating sugar metabolism in flies. Notably, thermogenetic activation of octopaminergic neurons or exogenous administration of octopamine, the invertebrate counterpart of noradrenaline, abrogates the effects of xylose isomerase on Drosophila locomotion. These findings reveal a previously unappreciated role for the gut microbiome in modulating locomotion, and identify octopaminergic neurons as mediators of peripheral microbial cues that regulate motor behaviour in animals. |
| التعليقات: | Comment in: Nature. 2018 Nov;563(7731):331-332. (PMID: 30425356) Comment in: Nat Chem Biol. 2019 Jan;15(1):2. (PMID: 30531903) Comment in: Mol Cell. 2019 Feb 7;73(3):395-397. (PMID: 30735653) |
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| معلومات مُعتمدة: | R01 NS085910 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 14O50WS8JD (Octopamine) EC 5.3.1.- (Aldose-Ketose Isomerases) EC 5.3.1.5 (xylose isomerase) |
| تواريخ الأحداث: | Date Created: 20181026 Date Completed: 20190520 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6237646 |
| DOI: | 10.1038/s41586-018-0634-9 |
| PMID: | 30356215 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1476-4687 |
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| DOI: | 10.1038/s41586-018-0634-9 |