دورية أكاديمية
Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET.
| العنوان: | Characterization of Diffuse Gliomas With Histone H3-G34 Mutation by MRI and Dynamic 18F-FET PET. |
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| المؤلفون: | Vettermann FJ, Felsberg J; Institute for Neuropathology, Heinrich-Heine-University, Düsseldorf, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf., Reifenberger G; Institute for Neuropathology, Heinrich-Heine-University, Düsseldorf, and German Cancer Consortium (DKTK), partner site Essen/Düsseldorf., Hasselblatt M; Institute for Neuropathology, University of Münster, Münster., Forbrig R; Institute of Neuroradiology, University Hospital, LMU Munich, Munich., Berding G; Department of Nuclear Medicine, Hannover Medical School, Hannover., la Fougère C; Department of Nuclear Medicine and Clinical Molecular Imaging, Eberhard Karls University, Tübingen., Galldiks N, Schittenhelm J; Institute of Neuropathology, Department of Pathology and Neuropathology, University of Tübingen, and Comprehensive Cancer Center Tübingen-Stuttgart, site Tübingen., Weis J; Institute of Neuropathology, RWTH Aachen University, Aachen., Albert NL, Schüller U |
| المصدر: | Clinical nuclear medicine [Clin Nucl Med] 2018 Dec; Vol. 43 (12), pp. 895-898. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Country of Publication: United States NLM ID: 7611109 Publication Model: Print Cited Medium: Internet ISSN: 1536-0229 (Electronic) Linking ISSN: 03639762 NLM ISO Abbreviation: Clin Nucl Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, Lippincott. |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging* , Positron-Emission Tomography*, Brain Neoplasms/*diagnostic imaging , Glioma/*diagnostic imaging , Histones/*genetics, Adolescent ; Adult ; Brain Neoplasms/genetics ; Child ; Female ; Glioma/genetics ; Humans ; Male ; Middle Aged ; Mutation ; Radiopharmaceuticals ; Tyrosine/analogs & derivatives |
| مستخلص: | Background: Recent data suggest that diffuse gliomas carrying mutations in codon 34 of the H3 histone family 3A protein represent a very rare, distinct subgroup of IDH-wild type malignant astrocytic gliomas. However, characteristics detectable by MRI and F-FET PET in H3-G34-mutant gliomas are unknown. Methods: We report on MRI and F-FET PET findings in 8 patients from 4 German centers with H3-G34-mutant diffuse gliomas. MRI analyses included multifocality, contrast enhancement, necrosis, cysts, hemorrhages, calcification, and edema. F-FET PET characteristics were evaluated on the basis of static F-FET PET parameters, such as maximal tumor-to-background ratio (TBRmax) and biological tumor volume (BTV), as well as the minimal time-to-peak (TTPmin) obtained from dynamic F-FET PET data. Results: MRI showed multifocal lesions in 2 of 8, contrast enhancement in 6 of 8, necrosis in 3 of 8, cysts in 3 of 8, hemorrhage in 1 of 8, and calcifications in 1 of 8 patients. None of the tumors showed marked peritumoral edema. However, all 8 H3-G34-mutant gliomas were characterized by a high uptake intensity on F-FET PET with a median TBRmax of 3.4 (range, 2.5-11.7) and a relatively diffuse uptake pattern leading to a large BTV (median, 41.9 mL; range, 7.5-115.6). Dynamic PET data revealed a short median TTPmin of 12.5 minutes. Conclusions: MRI features of diffuse gliomas with H3-G34 mutation may present very heterogeneously with some cases not even fulfilling the imaging criteria of high-grade glioma. In contrast, in F-FET PET, these tumors show an extensive and diffuse tracer uptake resulting in large BTV with a high TBRmax and a short TTPmin, thus resembling PET characteristics of aggressive high-grade gliomas, namely, glioblastomas. |
| المشرفين على المادة: | 0 (Histones) 0 (Radiopharmaceuticals) 1326R5J1IA ((18F)fluoroethyltyrosine) 42HK56048U (Tyrosine) |
| تواريخ الأحداث: | Date Created: 20181026 Date Completed: 20181231 Latest Revision: 20181231 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1097/RLU.0000000000002300 |
| PMID: | 30358620 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1536-0229 |
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| DOI: | 10.1097/RLU.0000000000002300 |