دورية أكاديمية
A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations.
| العنوان: | A Subset of Mesotheliomas With Improved Survival Occurring in Carriers of BAP1 and Other Germline Mutations. |
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| المؤلفون: | Pastorino S; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Yoshikawa Y; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Pass HI; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Emi M; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Nasu M; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Pagano I; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Takinishi Y; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Yamamoto R; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Minaai M; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Hashimoto-Tamaoki T; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Ohmuraya M; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Goto K; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Goparaju C; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Sarin KY; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Tanji M; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Bononi A; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Napolitano A; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Gaudino G; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Hesdorffer M; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Yang H; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA., Carbone M; Sandra Pastorino, Mitsuru Emi, Masaki Nasu, Ian Pagano, Yasutaka Takinishi, Ryuji Yamamoto, Michael Minaai, Keisuke Goto, Mika Tanji, Angela Bononi, Andrea Napolitano, Giovanni Gaudino, Haining Yang, and Michele Carbone, University of Hawaii Cancer Center, Honolulu, HI; Yoshie Yoshikawa, Mitsuru Emi, Tomoko Hashimoto-Tamaoki, and Masaki Ohmuraya, Hyogo College of Medicine, Hyogo, Japan; Mary Hesdorffer, Mesothelioma Applied Research Foundation, Washington DC; Harvey I. Pass and Chandra Goparaju, New York University Langone Medical Center, New York, NY; Andrea Neopolitano, University Campus Bio-Medico, Rome, Italy; and Kavita Y. Sarin, Stanford University, Stanford, CA. |
| المصدر: | Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2018 Oct 30, pp. JCO2018790352. Date of Electronic Publication: 2018 Oct 30. |
| Publication Model: | Ahead of Print |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol |
| أسماء مطبوعة: | Publication: 2003- : Alexandria, VA : American Society of Clinical Oncology Original Publication: New York, N.Y. : Grune & Stratton, c1983- |
| مستخلص: | Purpose: We hypothesized that four criteria could help identify malignant mesotheliomas (MMs) most likely linked to germline mutations of BAP1 or of other genes: family history of MM, BAP1-associated cancers, or multiple malignancies; or age younger than 50 years. Patients and Methods: Over the course of 7 years, 79 patients with MM met the four criteria; 22 of the 79 (28%) reported possible asbestos exposure. They were screened for germline BAP1 mutations by Sanger sequencing and by targeted next-generation sequencing (tNGS) for germline mutations in 55 additional cancer-linked genes. Deleterious mutations detected by tNGS were validated by Sanger sequencing. Results: Of the 79 patients, 43 (16 probands and 27 relatives) had deleterious germline BAP1 mutations. The median age at diagnosis was 54 years and median survival was 5 years. Among the remaining 36 patients with no BAP1 mutation, median age at diagnosis was 45 years, median survival was 9 years, and 12 had deleterious mutations of additional genes linked to cancer. When compared with patients with MMs in the SEER cohort, median age at diagnosis (72 years), median survival for all MM stages (8 months), and stage I (11 months) were significantly different from the 79 patients with MM in the current study ( P < .0001). Conclusion: We provide criteria that help identify a subset of patients with MM who had significantly improved survival. Most of these patients were not aware of asbestos exposure and carried either pathogenic germline mutations of BAP1 or of additional genes linked to cancer, some of which may have targeted-therapy options. These patients and their relatives are susceptible to development of additional cancers; therefore, genetic counseling and cancer screening should be considered. |
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| معلومات مُعتمدة: | R01 CA198138 United States CA NCI NIH HHS; U01 CA111295 United States CA NCI NIH HHS |
| تواريخ الأحداث: | Date Created: 20181031 Latest Revision: 20240227 |
| رمز التحديث: | 20240227 |
| مُعرف محوري في PubMed: | PMC7162737 |
| DOI: | 10.1200/JCO.2018.79.0352 |
| PMID: | 30376426 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1527-7755 |
|---|---|
| DOI: | 10.1200/JCO.2018.79.0352 |