دورية أكاديمية
Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice
| العنوان: | Stress rapidly suppresses in vivo LH pulses and increases activation of RFRP-3 neurons in male mice |
|---|---|
| المؤلفون: | Yang JA; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, California, USA., Hughes JK; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, California, USA., Parra RA; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, California, USA., Volk KM; Neuroscience Program, Washington and Lee University, Lexington, Virginia, USA., Kauffman AS; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Diego, La Jolla, California, USA. |
| المصدر: | The Journal of endocrinology [J Endocrinol] 2018 Oct 31; Vol. 239 (3), pp. 339-350. Date of Electronic Publication: 2018 Oct 31. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 0375363 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-6805 (Electronic) Linking ISSN: 00220795 NLM ISO Abbreviation: J Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Bristol, UK : Society for Endocrinology |
| مواضيع طبية MeSH: | Kisspeptins/*metabolism , Luteinizing Hormone/*metabolism , Neuropeptides/*metabolism , Protein Precursors/*metabolism , Stress, Psychological/*metabolism , Tachykinins/*metabolism, Animals ; Corticosterone/blood ; Male ; Mice, Inbred C57BL ; Neurosecretory Systems/metabolism |
| مستخلص: | Restraint stress is a psychosocial stressor that suppresses reproductive status, including LH pulsatile secretion, but the neuroendocrine mechanisms underlying this inhibition remains unclear. Reproductive neural populations upstream of gonadotropin-releasing hormone (GnRH) neurons, such as kisspeptin, neurokinin B and RFRP-3 (GnIH) neurons, are possible targets for psychosocial stress to inhibit LH pulses, but this has not been well examined, especially in mice in which prior technical limitations prevented assessment of in vivo LH pulse secretion dynamics. Here, we examined whether one-time acute restraint stress alters in vivo LH pulsatility and reproductive neural populations in male mice, and what the time-course is for such alterations. We found that endogenous LH pulses in castrated male mice are robustly and rapidly suppressed by one-time, acute restraint stress, with suppression observed as quickly as 12–18 min. This rapid LH suppression parallels with increased in vivo corticosterone levels within 15 min of restraint stress. Although Kiss1, Tac2 and Rfrp gene expression in the hypothalamus did not significantly change after 90 or 180 min restraint stress, arcuate Kiss1 neural activation was significantly decreased after 180 min. Interestingly, hypothalamic Rfrp neuronal activation was strongly increased at early times after restraint stress initiation, but was attenuated to levels lower than controls by 180 min of restraint stress. Thus, the male neuroendocrine reproductive axis is quite sensitive to short-term stress exposure, with significantly decreased pulsatile LH secretion and increased hypothalamic Rfrp neuronal activation occurring rapidly, within minutes, and decreased Kiss1 neuronal activation also occurring after longer stress durations. |
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| معلومات مُعتمدة: | T32 HD007203 United States HD NICHD NIH HHS; R01 HD090161 United States HD NICHD NIH HHS; P50 HD028934 United States HD NICHD NIH HHS; P50 HD012303 United States HD NICHD NIH HHS; R24 HD102061 United States HD NICHD NIH HHS |
| المشرفين على المادة: | 0 (Kiss1 protein, mouse) 0 (Kisspeptins) 0 (Neuropeptides) 0 (Protein Precursors) 0 (RFamide peptide) 0 (Tachykinins) 0 (preprotachykinin) 9002-67-9 (Luteinizing Hormone) W980KJ009P (Corticosterone) |
| تواريخ الأحداث: | Date Created: 20181102 Date Completed: 20190911 Latest Revision: 20220409 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6214202 |
| DOI: | 10.1530/JOE-18-0449 |
| PMID: | 30382693 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1479-6805 |
|---|---|
| DOI: | 10.1530/JOE-18-0449 |