دورية أكاديمية
أعرض في EDS

Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children.

التفاصيل البيبلوغرافية
العنوان: Environmental Co-Exposure to Lead and Manganese and Intellectual Deficit in School-Aged Children.
المؤلفون: Menezes-Filho JA; Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. antomen@ufba.br., Carvalho CF; Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. chrissie.carvalho@pro.ucsal.br., Rodrigues JLG; Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. julgrodrigues3@gmail.com., Araújo CFS; Environmental and Public Health Program, National School of Public Health, Oswald Cruz Foundation, Rio de Janeiro 21041-210, Brazil. cecilia.araujo@posgrad.ensp.fiocruz.br., Dos Santos NR; Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. nathalias@ufba.br., Lima CS; Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. cassio.lima@ufba.br., Bandeira MJ; Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. matheus.jesus@ufba.br., Marques BLS; Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. lsmbrenoa@gmail.com., Anjos ALS; Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. anjos.ana@ufba.br., Bah HAF; Laboratory of Toxicology, School of Pharmacy, Federal University of Bahia, Salvador 40170-115, Brazil. ferreol40@hotmail.com., Abreu N; Institute of Psychology, Federal University of Bahia, Salvador 40170-115, Brazil. neander.abreu@ufba.br., Philibert A; Centre de Recherche Interdisciplinaire sur la Biologie, la Santé, la Société et l'Environnement (CINBIOSE), Université du Québec a Montreal, Montreal, QC H3C 3P8, Canada. philibert.aline@uqam.ca., Mergler D; Centre de Recherche Interdisciplinaire sur la Biologie, la Santé, la Société et l'Environnement (CINBIOSE), Université du Québec a Montreal, Montreal, QC H3C 3P8, Canada. mergler.donna@uqam.ca.
المصدر: International journal of environmental research and public health [Int J Environ Res Public Health] 2018 Oct 31; Vol. 15 (11). Date of Electronic Publication: 2018 Oct 31.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238455 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-4601 (Electronic) Linking ISSN: 16604601 NLM ISO Abbreviation: Int J Environ Res Public Health Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI, c2004-
مواضيع طبية MeSH: Dust/*analysis , Environmental Exposure/*adverse effects , Intelligence/*physiology , Lead/*adverse effects , Manganese/*adverse effects , Students/*statistics & numerical data, Brain Diseases ; Brazil ; Child ; Cross-Sectional Studies ; Environmental Exposure/analysis ; Environmental Monitoring ; Female ; Hair/chemistry ; Humans ; Intelligence Tests ; Lead/blood ; Male ; Manganese/blood ; Manganese Poisoning/epidemiology ; Manufacturing and Industrial Facilities ; Nails/chemistry ; Schools ; Urban Population/statistics & numerical data
مستخلص: Studies have demonstrated that, for urban children, dust represents the main exposure to sources of metals like lead (Pb) and manganese (Mn). We aimed to investigate the exposure to these metals and their association with intellectual deficit in children living in an industrial region. This cross-sectional study recruited volunteers from four elementary schools in the town of Simões Filho, Brazil. We evaluated 225 school-aged children (7⁻12 years) for blood lead (PbB) and manganese hair (MnH) and toenails (MnTn) by graphite furnace atomic absorption spectrometry. Child and maternal IQs were estimated using the Wechsler Abbreviated Scale for Intelligence (WASI). Median and range PbB were 1.2 (0.3⁻15.6) μg/dL. MnH and MnTn medians (ranges) were 0.74 (0.16⁻8.79) μg/g and 0.85 (0.15⁻13.30) μg/g, respectively. After adjusting for maternal IQ, age and Mn exposure, child IQ drops by 8.6 points for a 10-fold increase in PbB levels. Moreover, an effect modification of Mn co-exposure was observed. In children with low MnTn, association between Pb and child IQ was not significant (β = -6.780, p = 0.172). However, in those with high MnTn, the association was increased by 27.9% (β = -8.70, p = 0.036). Low Pb exposure is associated with intellectual deficit in children, especially in those with high MnTn.
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فهرسة مساهمة: Keywords: children; environmental contamination; intellectual function; lead; manganese
المشرفين على المادة: 0 (Dust)
2P299V784P (Lead)
42Z2K6ZL8P (Manganese)
تواريخ الأحداث: Date Created: 20181103 Date Completed: 20190226 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC6266231
DOI: 10.3390/ijerph15112418
PMID: 30384464
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-4601
DOI:10.3390/ijerph15112418