دورية أكاديمية
The role of ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of uterosacral and cardinal ligaments in the etiopathogenesis of pelvic organ prolapse among women without stress urinary incontinence.
| العنوان: | The role of ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of uterosacral and cardinal ligaments in the etiopathogenesis of pelvic organ prolapse among women without stress urinary incontinence. |
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| المؤلفون: | Tola EN; Suleyman Demirel University Faculty of Medicine, Department of Obstetrics and Gynecology, Isparta, Turkey. Electronic address: perinatalog@hotmail.com., Koroglu N; Kanuni Sultan Suleyman Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey., Yıldırım GY; Kanuni Sultan Suleyman Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey., Koca HB; Afyon Kocatepe University Faculty of Medicine, Department of Biochemistry, Afyon, Turkey. |
| المصدر: | European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2018 Dec; Vol. 231, pp. 158-163. Date of Electronic Publication: 2018 Oct 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 0375672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7654 (Electronic) Linking ISSN: 03012115 NLM ISO Abbreviation: Eur J Obstet Gynecol Reprod Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Original Publication: Amsterdam, Excerpta Medica. |
| مواضيع طبية MeSH: | ADAMTS Proteins/*metabolism , Collagen Type I/*metabolism , Ligaments/*metabolism , Pelvic Organ Prolapse/*etiology , Tissue Inhibitor of Metalloproteinase-3/*metabolism , Uterus/*metabolism, Aged ; Female ; Humans ; Middle Aged ; Pelvic Organ Prolapse/metabolism ; Pelvic Organ Prolapse/pathology ; Prospective Studies ; Uterus/pathology |
| مستخلص: | Objective(s): To investigate the potential role of 'a disintegrin-like and metalloproteinase with thrombospondin type motifs-2 (ADAMTS-2), collagen type-1, tissue inhibitor of metalloproteinases-3 (TIMP-3) and papilin' levels in the uterosacral ligament (USL) and cardinal ligament (CL) of the uterus on the etiopathogenesis of pelvic organ prolapse (POP) among postmenopausal women without stress urinary incontinence (SUI). Study Design: A total of 45 postmenopausal women, 22 diagnosed as POP stage III-IV and 23 age- and body mass index (BMI)-matched controls referred for hysterectomy due to POP or benign gynecological disease, respectively, were recruited prospectively for our study. The biopsies of the USL and CL were obtained during hysterectomy. ADAMTS-2, collagen type-1, TIMP-3 and papilin levels were determined by enzyme-linked immunosorbent assay (ELISA) method after tissue homogenization. We excluded patients who smoked or presented with SUI. Results: There were no differences in terms of demographic features including age, BMI, obesity, duration of menopause, gravidity, parity, delivery modes and family history for POP between the POP and non-POP groups. Significant differences in the levels of ADAMTS-2, collagen type-1, TIMP-3 and papilin of USL were noted among the groups. Females with POP had lower levels of ADAMTS-2, collagen type-1, TIMP-3 and papilin in the USL compared to non-POP females. All investigated markers in the CL were also decreased in the POP group, but this relationship was not statistically significant. When age, duration of menopause, gravidity, parity and obesity were taken as covariates, only the USL papilin levels were negatively predictive for the development of POP. Conclusion(s): ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of the USL play essential roles in the etiopathogenesis of POP among postmenopausal women without SUI. Moreover, significantly decreased USL papilin levels in females with POP suggest the importance of the USL and the impact of papilin on the development of POP. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ADAMTS-2; Collagen type-1; Papilin; Pelvic organ prolapse; TIMP-3 |
| المشرفين على المادة: | 0 (Collagen Type I) 0 (Tissue Inhibitor of Metalloproteinase-3) EC 3.4.24.- (ADAMTS Proteins) EC 3.4.24.14 (ADAMTS2 protein, human) |
| تواريخ الأحداث: | Date Created: 20181103 Date Completed: 20190401 Latest Revision: 20190401 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ejogrb.2018.10.043 |
| PMID: | 30388611 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7654 |
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| DOI: | 10.1016/j.ejogrb.2018.10.043 |