دورية أكاديمية
أعرض في EDS

Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.

التفاصيل البيبلوغرافية
العنوان: Regulator of Calcineurin 1 helps coordinate whole-body metabolism and thermogenesis.
المؤلفون: Rotter D; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Peiris H; Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia., Grinsfelder DB; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Martin AM; Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia., Burchfield J; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Parra V; Faculty of Chemical and Pharmaceutical Sciences & Faculty of Medicine, Advanced Center for Chronic Diseases (ACCDiS) and Center for Exercise Metabolism and Cancer (CEMC), University of Chile, Santiago, Chile., Hull C; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Morales CR; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Jessup CF; Department of Anatomy and Histology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia., Matusica D; Department of Anatomy and Histology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia., Parks BW; Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA., Lusis AJ; Division of Cardiology, Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA., Nguyen NUN; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Oh M; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Chemistry, Pohang University of Science and Technology, Pohang, South Korea., Iyoke I; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Jakkampudi T; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., McMillan DR; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Children's Medical Centre, Dallas, TX, USA., Sadek HA; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Watt MJ; The Department of Physiology and Monash Biomedicine Discovery Institute, Metabolic Disease and Obesity Program, Monash University, Clayton, Vic., Australia., Gupta RK; Touchstone Diabetes Center and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA., Pritchard MA; Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Vic., Australia., Keating DJ; Department of Human Physiology and Centre for Neuroscience, Flinders University, Adelaide, SA, Australia damien.keating@flinders.edu.au beverly.rothermel@utsouthwestern.edu.; South Australian Health and Medical Research Institute (SAHMRI), Adelaide, SA, Australia., Rothermel BA; Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA damien.keating@flinders.edu.au beverly.rothermel@utsouthwestern.edu.; Department of Molecular Biology, University of Texas Southwestern Medical Centre, Dallas, TX, USA.
المصدر: EMBO reports [EMBO Rep] 2018 Dec; Vol. 19 (12). Date of Electronic Publication: 2018 Nov 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : [London] : Nature Publishing Group
Original Publication: Oxford, UK : Published for EMBO by Oxford University Press, 2000-
مواضيع طبية MeSH: Metabolism*/drug effects , Thermogenesis*/drug effects, Intracellular Signaling Peptides and Proteins/*metabolism , Muscle Proteins/*metabolism, 3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/drug effects ; Adipocytes/metabolism ; Adipose Tissue/metabolism ; Adipose Tissue, Beige/drug effects ; Adipose Tissue, Beige/metabolism ; Adipose Tissue, White/drug effects ; Adipose Tissue, White/metabolism ; Adrenergic Agents/pharmacology ; Animals ; Calcineurin/metabolism ; Calcium-Binding Proteins ; Cell Differentiation/drug effects ; Cold Temperature ; Female ; Insulin Resistance ; Intracellular Signaling Peptides and Proteins/deficiency ; Lipid Metabolism/drug effects ; Liver/metabolism ; Male ; Metabolic Syndrome/metabolism ; Mice ; Mice, Knockout ; Muscle Proteins/deficiency ; Muscle Proteins/genetics ; Muscle, Skeletal/metabolism ; Muscle, Striated/metabolism ; Obesity/metabolism ; Obesity/pathology ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Promoter Regions, Genetic/genetics ; Proteolipids/genetics ; Proteolipids/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Uncoupling Protein 1/metabolism
مستخلص: Increasing non-shivering thermogenesis (NST), which expends calories as heat rather than storing them as fat, is championed as an effective way to combat obesity and metabolic disease. Innate mechanisms constraining the capacity for NST present a fundamental limitation to this approach, yet are not well understood. Here, we provide evidence that Regulator of Calcineurin 1 ( RCAN1 ), a feedback inhibitor of the calcium-activated protein phosphatase calcineurin (CN), acts to suppress two distinctly different mechanisms of non-shivering thermogenesis (NST): one involving the activation of UCP1 expression in white adipose tissue, the other mediated by sarcolipin (SLN) in skeletal muscle. UCP1 generates heat at the expense of reducing ATP production, whereas SLN increases ATP consumption to generate heat. Gene expression profiles demonstrate a high correlation between Rcan1 expression and metabolic syndrome. On an evolutionary timescale, in the context of limited food resources, systemic suppression of prolonged NST by RCAN1 might have been beneficial; however, in the face of caloric abundance, RCAN1-mediated suppression of these adaptive avenues of energy expenditure may now contribute to the growing epidemic of obesity.
(© 2018 The Authors.)
References: J Biol Chem. 2010 Dec 17;285(51):40050-9. (PMID: 20943662)
J Mol Cell Cardiol. 2007 Aug;43(2):215-22. (PMID: 17561107)
Mol Metab. 2015 Sep 25;4(11):823-33. (PMID: 26629406)
Cell Metab. 2016 Feb 9;23(2):350-9. (PMID: 26626462)
PLoS Genet. 2016 May 19;12(5):e1006033. (PMID: 27195491)
Obesity (Silver Spring). 2010 Oct;18(10):1902-5. (PMID: 20057372)
Stain Technol. 1990;65(5):231-41. (PMID: 1703671)
J Pediatr. 2016 Jun;173:143-8. (PMID: 26987801)
Diabetologia. 2015 Sep;58(9):1969-77. (PMID: 26109214)
Biochem Biophys Res Commun. 2009 Apr 17;381(4):537-43. (PMID: 19233136)
Circ Res. 2018 Mar 16;122(6):e20-e33. (PMID: 29362227)
Nature. 2006 Sep 21;443(7109):345-9. (PMID: 16988714)
Physiol Rev. 2015 Jan;95(1):47-82. (PMID: 25540138)
Nat Commun. 2016 Jul 27;7:12205. (PMID: 27461402)
Biol Cell. 2003 Sep;95(6):399-406. (PMID: 14519557)
Cell Metab. 2015 Feb 3;21(2):334-347. (PMID: 25651185)
FASEB J. 2007 Oct;21(12):3023-8. (PMID: 17595344)
BMB Rep. 2009 Jan 31;42(1):6-15. (PMID: 19192387)
Ann Intern Med. 2003 Jan 7;138(1):24-32. (PMID: 12513041)
Hum Mol Genet. 2000 Jul 1;9(11):1681-90. (PMID: 10861295)
N Engl J Med. 2009 Apr 9;360(15):1509-17. (PMID: 19357406)
J Biol Chem. 2010 May 28;285(22):16623-31. (PMID: 20371871)
Nat Med. 2012 Oct;18(10):1575-9. (PMID: 22961106)
J Appl Physiol (1985). 1993 Nov;75(5):2337-40. (PMID: 8307894)
Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):669-74. (PMID: 12515860)
Mol Cell Biol. 2006 Oct;26(20):7372-87. (PMID: 16908540)
J Physiol. 2011 Nov 1;589(Pt 21):5021-31. (PMID: 21911615)
JAMA Psychiatry. 2013 Oct;70(10):1011-9. (PMID: 23925723)
Pharmacogenomics J. 2017 Jan;17(1):69-75. (PMID: 26644205)
FEMS Immunol Med Microbiol. 2011 Feb;61(1):103-13. (PMID: 21073546)
Cell. 1998 Mar 20;92(6):829-39. (PMID: 9529258)
Nat Immunol. 2014 Nov;15(11):1046-54. (PMID: 25263126)
Endocrinology. 2012 Nov;153(11):5212-21. (PMID: 23011918)
Front Immunol. 2017 Oct 20;8:1323. (PMID: 29104573)
Am J Transplant. 2004 Apr;4(4):583-95. (PMID: 15023151)
Genomics. 1997 Nov 1;45(3):541-53. (PMID: 9367679)
J Neurochem. 2013 Feb;124(3):290-9. (PMID: 23134420)
Diabetes. 2015 Jul;64(7):2352-60. (PMID: 26050667)
Nat Rev Mol Cell Biol. 2011 Mar;12(3):141-51. (PMID: 21346730)
Diabetes Care. 2011 May;34 Suppl 2:S285-90. (PMID: 21525470)
Nat Med. 2013 Oct;19(10):1252-63. (PMID: 24100998)
Eur J Clin Nutr. 2013 Oct;67(10):1087-91. (PMID: 23900244)
Neuroimage. 2006 Jul 1;31(3):1116-28. (PMID: 16545965)
Mol Cell Biol. 2005 Aug;25(15):6629-38. (PMID: 16024798)
Biochim Biophys Acta. 2009 Dec;1787(12):1451-7. (PMID: 19539600)
Genome Res. 2008 May;18(5):706-16. (PMID: 18347327)
J Biol Chem. 2006 Oct 20;281(42):31894-908. (PMID: 16914547)
Gastroenterology. 2010 Aug;139(2):609-19, 619.e1-6. (PMID: 20438729)
Genes Dev. 1998 Aug 15;12(16):2499-509. (PMID: 9716403)
J Cell Biol. 1963 May;17:299-313. (PMID: 13985244)
J Clin Invest. 2006 Jul;116(7):1793-801. (PMID: 16823477)
J Biol Chem. 2015 Apr 24;290(17):10840-9. (PMID: 25713078)
Oncotarget. 2017 Jul 18;8(29):48098-48109. (PMID: 28624805)
J Biol Chem. 2006 Dec 22;281(51):39051-61. (PMID: 17062574)
Physiol Genomics. 2015 Mar;47(3):58-74. (PMID: 25572546)
J Biol Chem. 2016 Aug 12;291(33):17247-57. (PMID: 27298322)
Pharmacol Res. 2018 Jul;133:236-249. (PMID: 29309904)
Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14379-84. (PMID: 16980408)
Mol Metab. 2015 Nov 06;5(1):34-46. (PMID: 26844205)
PLoS Genet. 2008 Feb;4(2):e32. (PMID: 18282109)
Pharmacol Res. 2015 Dec;102:270-5. (PMID: 26521759)
Hum Mol Genet. 2007 May 1;16(9):1039-50. (PMID: 17341486)
J Biol Chem. 2012 Mar 16;287(12):9100-11. (PMID: 22282499)
Eur J Cardiovasc Prev Rehabil. 2008 Feb;15(1):35-42. (PMID: 18277183)
Physiol Rev. 1997 Jul;77(3):731-58. (PMID: 9234964)
PLoS One. 2011 Jan 27;6(1):e14605. (PMID: 21298050)
Mol Metab. 2018 Jan;7:35-44. (PMID: 29198749)
BMC Endocr Disord. 2012 Oct 15;12:22. (PMID: 23067442)
PLoS One. 2013 Jul 01;8(7):e68924. (PMID: 23840903)
Diabetes. 2002 Mar;51(3):691-8. (PMID: 11872668)
Int J Biol Sci. 2010 Nov 22;6(7):691-9. (PMID: 21103072)
Transplantation. 2012 Feb 15;93(3):325-30. (PMID: 22234350)
J Mol Cell Cardiol. 2016 Feb;91:81-91. (PMID: 26743715)
Nature. 1997 May 1;387(6628):90-4. (PMID: 9139827)
Eur J Hum Genet. 2014 Jan;22(1):144-7. (PMID: 23695286)
J Biol Chem. 2000 Mar 24;275(12):8719-25. (PMID: 10722714)
J Biol Chem. 1957 May;226(1):497-509. (PMID: 13428781)
J Biol Chem. 2015 May 8;290(19):12282-9. (PMID: 25825499)
Circ Res. 2011 Feb 18;108(4):437-45. (PMID: 21233454)
Nat Protoc. 2006;1(1):16-22. (PMID: 17406207)
Physiol Rep. 2015 Sep;3(9):null. (PMID: 26400985)
Transplant Proc. 2015 Jan-Feb;47(1):127-9. (PMID: 25645789)
J Mol Cell Cardiol. 2014 Sep;74:103-11. (PMID: 24838101)
Circ Res. 2000 Dec 8;87(12):E61-8. (PMID: 11110780)
Mol Immunol. 2016 Sep;77:26-33. (PMID: 27449908)
J Immunol. 2013 Dec 15;191(12):5885-94. (PMID: 24218457)
Neuropharmacology. 2017 Sep 1;123:55-66. (PMID: 28400260)
Nature. 2010 Dec 16;468(7326):933-9. (PMID: 21164481)
Hum Mol Genet. 2008 Apr 1;17(7):1020-30. (PMID: 18180251)
Genomics. 1997 Sep 15;44(3):358-61. (PMID: 9325060)
Cell. 2004 Oct 1;119(1):121-35. (PMID: 15454086)
Mol Biol Rep. 2014 Jan;41(1):125-30. (PMID: 24264430)
Nat Med. 2013 May;19(5):631-4. (PMID: 23603813)
J Immunol. 2013 May 15;190(10):5178-86. (PMID: 23589609)
معلومات مُعتمدة: R01 DK104789 United States DK NIDDK NIH HHS; R01 HL072016 United States HL NHLBI NIH HHS; R01 HL102478 United States HL NHLBI NIH HHS; U54 HD087351 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: Down syndrome; RCAN1; adaptive thermogenesis; obesity; sarcolipin
المشرفين على المادة: 0 (Adrenergic Agents)
0 (Calcium-Binding Proteins)
0 (DSCR1 protein, mouse)
0 (Intracellular Signaling Peptides and Proteins)
0 (Muscle Proteins)
0 (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha)
0 (Proteolipids)
0 (RNA, Messenger)
0 (Uncoupling Protein 1)
145018-73-1 (sarcolipin)
EC 3.1.3.16 (Calcineurin)
تواريخ الأحداث: Date Created: 20181104 Date Completed: 20190718 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6280800
DOI: 10.15252/embr.201744706
PMID: 30389725
قاعدة البيانات: MEDLINE
الوصف
تدمد:1469-3178
DOI:10.15252/embr.201744706