دورية أكاديمية
أعرض في EDS

Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques.

التفاصيل البيبلوغرافية
العنوان: Mucosal T Helper 17 and T Regulatory Cell Homeostasis Correlate with Acute Simian Immunodeficiency Virus Viremia and Responsiveness to Antiretroviral Therapy in Macaques.
المؤلفون: O'Connor MA; 1 Department of Microbiology, University of Washington, Seattle, Washington.; 2 Washington National Primate Research Center, Seattle, Washington., Munson PV; 1 Department of Microbiology, University of Washington, Seattle, Washington.; 2 Washington National Primate Research Center, Seattle, Washington., Tunggal HC; 1 Department of Microbiology, University of Washington, Seattle, Washington.; 2 Washington National Primate Research Center, Seattle, Washington., Hajari N; 1 Department of Microbiology, University of Washington, Seattle, Washington.; 2 Washington National Primate Research Center, Seattle, Washington., Lewis TB; 1 Department of Microbiology, University of Washington, Seattle, Washington.; 2 Washington National Primate Research Center, Seattle, Washington., Bratt D; 2 Washington National Primate Research Center, Seattle, Washington., Moats C; 2 Washington National Primate Research Center, Seattle, Washington., Smedley J; 2 Washington National Primate Research Center, Seattle, Washington., Bagley KC; 3 Profectus Biosciences, Inc., Baltimore, Maryland., Mullins JI; 1 Department of Microbiology, University of Washington, Seattle, Washington., Fuller DH; 1 Department of Microbiology, University of Washington, Seattle, Washington.; 2 Washington National Primate Research Center, Seattle, Washington.
المصدر: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2019 Mar; Vol. 35 (3), pp. 295-305. Date of Electronic Publication: 2019 Jan 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8709376 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-8405 (Electronic) Linking ISSN: 08892229 NLM ISO Abbreviation: AIDS Res Hum Retroviruses Subsets: MEDLINE
أسماء مطبوعة: Publication: Larchmont, NY : Mary Ann Liebert
Original Publication: [New York] : Mary Ann Liebert, [c1987-
مواضيع طبية MeSH: Anti-Retroviral Agents/*therapeutic use , Homeostasis/*immunology , Simian Acquired Immunodeficiency Syndrome/*drug therapy , Simian Acquired Immunodeficiency Syndrome/*virology , Simian Immunodeficiency Virus/*pathogenicity , T-Lymphocytes, Regulatory/*immunology , Th17 Cells/*immunology , Viremia/*virology, Animals ; Anti-Retroviral Agents/administration & dosage ; Colon/pathology ; Disease Models, Animal ; HIV Infections/immunology ; Intestinal Mucosa/immunology ; Lymph Nodes/immunology ; Macaca mulatta ; Male ; Mesentery ; Monkey Diseases/drug therapy ; T-Lymphocytes, Regulatory/metabolism ; Treatment Outcome ; Viral Load/genetics
مستخلص: Depletion of gut T helper 17 (Th17) cells during HIV infection leads to decreased mucosal integrity and increased disease progression. Conversely, T regulatory (Treg) cells may inhibit antiviral responses or immune activation. In HIV elite controllers, a balanced Th17/Treg ratio is maintained in the blood, suggesting a role for these responses in controlling inflammation and viral replication. HIV-infected individuals exhibit a range in responsiveness to combination antiretroviral therapy (cART). Given the link between the Th17/Treg ratio and HIV disease, we reasoned these responses may play a role in cART responsiveness. In this study, we investigated the relationship between the mucosal Th17/Treg ratio to acute simian immunodeficiency virus (SIV) viremia and the response to cART. Nineteen rhesus macaques were infected with highly pathogenic SIVΔB670 virus and cART was initiated 6 weeks postinfection. Mucosal CD4 T cell subsets were assessed by intracellular cytokine staining in the colon and mesenteric lymph nodes. Higher baseline Th17/Treg ratios corresponded with increased acute SIV viremia. Th17/Treg ratios decreased during acute SIV infection and were not restored during cART, and this corresponded to increased gut immune activation (Ki67 + ), markers of microbial translocation (sCD14), and T cell exhaustion (TIGIT + ). Animals that maintained a more balanced mucosal Th17/Treg ratio at the time of cART initiation exhibited a better virological response to cART and maintained higher peripheral CD4 counts. These results suggest mucosal Th17 and Treg homeostasis influences acute viremia and the response to cART, a result that suggests therapeutic interventions that improve the Th17/Treg ratio before or during cART may improve treatment of HIV.
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معلومات مُعتمدة: P51 OD011092 United States OD NIH HHS; P51 OD010425 United States OD NIH HHS; T32 AI007140 United States AI NIAID NIH HHS; R44 AI110315 United States AI NIAID NIH HHS; UM1 AI126623 United States AI NIAID NIH HHS; R01 AI104679 United States AI NIAID NIH HHS; P30 AI027757 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Th17; Treg; antiretroviral therapy; mucosal immune responses; rhesus macaque; simian immunodeficiency virus
المشرفين على المادة: 0 (Anti-Retroviral Agents)
تواريخ الأحداث: Date Created: 20181107 Date Completed: 20200226 Latest Revision: 20200309
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6434588
DOI: 10.1089/AID.2018.0184
PMID: 30398361
قاعدة البيانات: MEDLINE
الوصف
تدمد:1931-8405
DOI:10.1089/AID.2018.0184