دورية أكاديمية
Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet.
| العنوان: | Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet. |
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| المؤلفون: | de Miranda MB; Biomaterials and Experimental Pathology Laboratory, Biological Sciences Department, Federal University of Ouro Preto (UFOP) - Morro do Cruzeiro Campus, 35.400-000, Minas Gerais, Brazil., Lanna MF; Biomaterials and Experimental Pathology Laboratory, Biological Sciences Department, Federal University of Ouro Preto (UFOP) - Morro do Cruzeiro Campus, 35.400-000, Minas Gerais, Brazil., Nascimento ALB; Biomaterials and Experimental Pathology Laboratory, Biological Sciences Department, Federal University of Ouro Preto (UFOP) - Morro do Cruzeiro Campus, 35.400-000, Minas Gerais, Brazil., de Paula CA; Clinical Analysis Department, Pharmacy School, Federal University of Ouro Preto (UFOP) - Morro do Cruzeiro Campus, 35.400-000, Minas Gerais, Brazil., de Souza ME; Experimental Nutrition Laboratory, Nutrition School, Federal University of Ouro Preto (UFOP) - Morro do Cruzeiro Campus, 35.400-000, Minas Gerais, Brazil., Felipetto M; Angiogenesis and Stem Cell Laboratory, Physiology and Biophysics Department, Biological Sciences Institute, Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31.270-901, Belo Horizonte, Minas Gerais, Brazil., da Silva Barcelos L; Angiogenesis and Stem Cell Laboratory, Physiology and Biophysics Department, Biological Sciences Institute, Federal University of Minas Gerais (UFMG), Av. Antônio Carlos 6627, 31.270-901, Belo Horizonte, Minas Gerais, Brazil., de Moura SAL; Biomaterials and Experimental Pathology Laboratory, Biological Sciences Department, Federal University of Ouro Preto (UFOP) - Morro do Cruzeiro Campus, 35.400-000, Minas Gerais, Brazil. Electronic address: sandralmoura@gmail.com. |
| المصدر: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2019 Jan; Vol. 109, pp. 610-620. Date of Electronic Publication: 2018 Nov 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Editions Scientifiques Elsevier Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982- |
| مواضيع طبية MeSH: | Diet, Protein-Restricted/*adverse effects , Inflammation Mediators/*metabolism , Propolis/*administration & dosage , Protein Deficiency/*drug therapy , Protein Deficiency/*metabolism, Animals ; Body Weight/drug effects ; Body Weight/physiology ; Ethanol/administration & dosage ; Female ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Mice ; Protein Deficiency/chemically induced ; Random Allocation ; Water/administration & dosage |
| مستخلص: | The occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation. However, its effect on inflammation in an impaired nutritional status is not known. The aim of this study was to characterize the effects of the administration of the hydroalcoholic extract of the green propolis in the chronic inflammatory process of mice submitted to a low-protein diet. For this, we used the subcutaneous implantation of sponge disks as an inflammatory model and the animals were distributed in the following groups: standard protein diet (12% protein content), control treatment; standard protein diet, propolis treatment; low-protein diet (3% protein content), control treatment; low-protein diet, propolis treatment. Propolis was given daily at a dose of 500 mg/kg (p.o.) during a period of 7 or 15 days. Our main findings show that animals fed with standard protein diet and treated with propolis had low levels of red blood cells, hemoglobin, and hematocrit, with the subsequent reestablishment of these levels, in addition to monocyte count elevation and higher TNF levels after one week of treatment. In the low-protein diet group, the propolis treatment provided a significant recovery in weight and maintenance of total serum protein levels at the end of two weeks of treatment. Histological analysis showed propolis reduced the inflammatory infiltrate in the sponges of both standard and low-protein diet groups. In addition, the propolis extract presented antiangiogenic effect in both groups. Therefore, our data suggests that the hydroalcoholic extract of the green propolis promotes weight recovery and avoid the reduction of protein levels, in addition to inhibit inflammation and angiogenesis in animals fed with a low-protein diet. (Copyright © 2018 Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Angiogenesis; Green; Hydroalcoholic extract; Inflammation; Low-protein diet; Propolis; Sponge implantation |
| المشرفين على المادة: | 0 (Inflammation Mediators) 059QF0KO0R (Water) 3K9958V90M (Ethanol) 9009-62-5 (Propolis) |
| تواريخ الأحداث: | Date Created: 20181107 Date Completed: 20190325 Latest Revision: 20190325 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.biopha.2018.10.116 |
| PMID: | 30399598 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1950-6007 |
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| DOI: | 10.1016/j.biopha.2018.10.116 |