"Normal-appearing" scalp areas are also affected in lichen planopilaris and frontal fibrosing alopecia: An observational histopathologic study of 40 patients.

التفاصيل البيبلوغرافية
العنوان:	"Normal-appearing" scalp areas are also affected in lichen planopilaris and frontal fibrosing alopecia: An observational histopathologic study of 40 patients.
المؤلفون:	Doche I; Department of Dermatology, University of Sao Paulo, Sao Paulo, Brazil., Romiti R; Department of Dermatology, University of Sao Paulo, Sao Paulo, Brazil., Hordinsky MK; Department of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota., Valente NS; Department of Dermatology, University of Sao Paulo, Sao Paulo, Brazil.
المصدر:	Experimental dermatology [Exp Dermatol] 2020 Mar; Vol. 29 (3), pp. 278-281. Date of Electronic Publication: 2018 Dec 21.
نوع المنشور:	Journal Article; Observational Study
اللغة:	English
بيانات الدورية:	Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9301549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0625 (Electronic) Linking ISSN: 09066705 NLM ISO Abbreviation: Exp Dermatol Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Copenhagen : Munksgaard, c1992-
مواضيع طبية MeSH:	Alopecia/metabolism , Fibrosis/metabolism , Lichen Planus/metabolism , Scalp/pathology, Adult ; Aged ; Aged, 80 and over ; Alopecia/diagnosis ; Biopsy ; Dermatology ; Female ; Fibrosis/diagnosis ; Humans ; Inflammation ; Lichen Planus/diagnosis ; Lymphocytes/pathology ; Male ; Middle Aged
مستخلص:	Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocyte-mediated scarring alopecias which clinically affect primarily the anterior and mid-scalp. However, unaffected scalp areas have not yet been investigated in a systemic manner. In this study, we assessed histopathologic changes in affected and unaffected scalp in both diseases and healthy control subjects and compared these findings with clinical signs and scalp symptoms. We have demonstrated that "normal-appearing" scalp that is devoid of clinical lesions of LPP and FFA showed lymphocytic perifollicular inflammation around the isthmus/infundibulum areas in 65% of biopsy specimens, perifollicular fibrosis in 15% and mucin deposits in 7.5% of the cases. None of these findings were found in control samples. No direct correlation was found between the degree of histopathological inflammation, scalp symptoms and clinical lesions in the corresponding affected scalp areas. This preliminary study suggests that both diseases may be more generalized processes which affect the scalp and therefore need systemic or total scalp therapy. (© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
References:	P. Mirmirani, A. Willey, J. T. Headington, K. Stenn, T. H. McCalmont, V. H. Price, J. Am. Acad. Dermatol. 2005, 52, 637. P. Assouly, P. Reygagne, Semin. Cutan. Med. Surg. 2009, 28, 3. L. Rudnicka, A. Rakowska, J. Eur. Acad. Dermatol. Venereol. 2017, 31, 1579. S. Vañó-Galván, A. M. Molina-Ruiz, C. Serrano-Falcón, S. Arias-Santiago, A. R. Rodrigues-Barata, G. Garnacho-Saucedo, A. Martorell-Calatayud, P. Fernández-Crehuet, R. Grimalt, B. Aranegui, E. Grillo, B. Diaz-Ley, R. Salido, S. Pérez-Gala, S. Serrano, J. C. Moreno, P. Jaén, F. M. Camacho, J. Am. Acad. Dermatol. 2014, 70, 670. A. Donati, L. Molina, I. Doche, N. Y. S. Valente, A. Donati, Arch. Dermatol. 2011, 47, 1424. N. C. Dlova, Br. J. Dermatol. 2013, 168, 439. S. Khan, D. A. Fenton, C. M. Stefanato, Int. J. Trichology. 2013, 5, 217. C. Chiang, D. Sah, B. K. Cho, B. E. Ochoa, V. H. Price, J. Am. Acad. Dermatol. 2010, 62, 387.
فهرسة مساهمة:	Keywords: fibrosis; histopathology; lymphocytic inflammation; mucin; scarring alopecias
SCR Disease Name:	Lichen planus follicularis
تواريخ الأحداث:	Date Created: 20181108 Date Completed: 20210927 Latest Revision: 20210927
رمز التحديث:	20231215
DOI:	10.1111/exd.13834
PMID:	30403306
قاعدة البيانات:	MEDLINE

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تدمد:	1600-0625
DOI:	10.1111/exd.13834