دورية أكاديمية
أعرض في EDS

Right heart size and function significantly correlate in patients with pulmonary arterial hypertension - a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Right heart size and function significantly correlate in patients with pulmonary arterial hypertension - a cross-sectional study.
المؤلفون: Fischer L; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany., Benjamin N; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Blank N; Department of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Egenlauf B; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Fischer C; Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany., Harutyunova S; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Koegler M; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany., Lorenz HM; Department of Rheumatology, University Hospital Heidelberg, Heidelberg, Germany., Marra AM; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.; IRCCS SDN Research Institute, Naples, Italy., Nagel C; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.; Lung Centre, Klinikum Mittelbaden, Baden-Baden Balg, Baden-Baden, Germany., Xanthouli P; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany., Bossone E; Heart Department, Cardiology Division, 'Cava de' Tirreni and Amalfi Coast' Hospital, University of Salerno, Salerno, Italy., Grünig E; Centre for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Röntgenstrasse 1, D-69126, Heidelberg, Germany. ekkehard.gruenig@med.uni-heidelberg.de.; Translational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), Heidelberg, Germany. ekkehard.gruenig@med.uni-heidelberg.de.
المصدر: Respiratory research [Respir Res] 2018 Nov 08; Vol. 19 (1), pp. 216. Date of Electronic Publication: 2018 Nov 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 2001- : London : BioMed Central Ltd.
Original Publication: London : Current Science Ltd., c2000-
مواضيع طبية MeSH: Atrial Function, Right/*physiology , Heart Atria/*diagnostic imaging , Heart Ventricles/*diagnostic imaging , Hypertension, Pulmonary/*diagnostic imaging , Hypertension, Pulmonary/*physiopathology , Ventricular Function, Right/*physiology, Adult ; Aged ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Organ Size/physiology ; Retrospective Studies
مستخلص: Background: The objective of this study was to assess, whether right atrial (RA) and ventricular (RV) size is related to RV pump function at rest and during exercise in patients with pulmonary arterial hypertension (PAH).
Methods: We included 54 patients with invasively diagnosed PAH that had been stable on targeted medication. All patients underwent clinical assessments including right heart catheterization and echocardiography at rest and during exercise. RV output reserve was defined as increase of cardiac index (CI) from rest to peak exercise (∆CI exercise ). Patients were classified according to the median of RA and RV-area. RV pump function and further clinical parameters were compared between groups by student's t-test. Uni- and multivariate Pearson correlation analyses were performed.
Results: Patients with larger RA and/or RV-areas (above a median of 16 and 20cm 2 , respectively) showed significantly lower ∆CI exercise , higher mean pulmonary arterial pressure, pulmonary vascular resistance at rest and NT-proBNP levels. Furthermore, patients with higher RV-areas presented with a significantly lower RV stroke volume and pulmonary arterial compliance at peak exercise than patients with smaller RV-size. RV area was identified as the only independent predictor of RV output reserve.
Conclusion: RV and RA areas represent valuable and easily accessible indicators of RV pump function at rest and during exercise. Cardiac output reserve should be considered as an important clinical parameter. Prospective studies are needed for further evaluation.
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فهرسة مساهمة: Keywords: Pulmonary hypertension; Pump function; Right atrial size; Right ventricular output reserve; Right ventricular size
تواريخ الأحداث: Date Created: 20181110 Date Completed: 20190225 Latest Revision: 20190225
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6225631
DOI: 10.1186/s12931-018-0913-x
PMID: 30409145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1465-993X
DOI:10.1186/s12931-018-0913-x