دورية أكاديمية
[The evaluation of the effectiveness of the application of bischofite-modified yellow clay (an experimental studi)].
| العنوان: | [The evaluation of the effectiveness of the application of bischofite-modified yellow clay (an experimental studi)]. |
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| عنوان ترانسليتريتد: | Otsenka éffektivnosti primeneniia zheltoĭ gliny, modifitsirovannoĭ bishofitom (éksperimental'noe issledovanie). |
| المؤلفون: | Sagradyan GV; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia., Abramtsova AV; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia., Cherevashchenko LA; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia., Ahkubekova NK; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia., Urvacheva EE; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia., Ovsienko AB; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia., Tereshin AT; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia., Vasin VA; Pyatigorsk state research institute of balneotherapeutics, Russian Federal Medical Biological Agency, Pyatigorsk, Russia. |
| المصدر: | Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury [Vopr Kurortol Fizioter Lech Fiz Kult] 2018; Vol. 95 (5), pp. 40-48. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Media Sfera Country of Publication: Russia (Federation) NLM ID: 2984868R Publication Model: Print Cited Medium: Print ISSN: 0042-8787 (Print) Linking ISSN: 00428787 NLM ISO Abbreviation: Vopr Kurortol Fizioter Lech Fiz Kult Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Media Sfera Original Publication: Moskva : Izdatelstvo Meditsina |
| مواضيع طبية MeSH: | Magnesium Chloride* , Minerals*, Arthritis, Experimental/*therapy , Clay/*chemistry, Animals ; B-Lymphocytes ; Male ; Rats ; Rats, Wistar ; T-Lymphocytes ; Treatment Outcome |
| مستخلص: | Background: The topical problems in balneotherapeutics and health resort activities in general are the development of the yellow clay-based preparations enriched in the natural mineral bischofite and the investigation of their therapeutic effects with the purpose of improvement of their curative potential. Aim: The objective of the present study was to evaluate the effectiveness of the course of the experimental therapeutic applications of the yellow clay obtained by the open pit mining of its deposits located in the vicinity of Pyatigorsk and modified by the addition of bischofite. Material and Methods: The experiments were carried out with the use of 57 eugamic Wistar male rats with adjuvant arthritis. The yellow clay supplemented with bischofite in various concentrations was applied in 12 procedures each 15 minutes in duration every other or every two days beginning from the 38 th day of experimentally-induced arthritis. The animals were allocated to five groups as follows: group 1 included the healthy animals that served as controls (n=5), groups 2-5 were comprised of the animals with adjuvant arthritis. The animals included in group 2 served as the experimental model of adjuvant arthritis (n=8), those comprising group 3 were treated by the applications of yellow clay without additives (n=14), group 4 was composed of the animals with adjuvant arthritis treated by the applications of yellow clay containing 10% of bischofite (n=15), the animals in group 5 having adjuvant arthritis were treated by the applications of yellow clay containing 20% of bischofite (n=15). Results: The study has demonstrated the reduction of the reactively enhanced relative abundance of, activated T-cells, and B-lymphocytes down to the respective control values in the animals with adjuvant arthritis after the course of applications of the yellow clay preparations. Simultaneously, normalization of the immunoregulatory index, IRI, (the T-helpers to cytotoxic T-lymphocytes ratio) was documented. The treatment was associated with the strong dependence of the interleukin (IL-1β) contents on the cortisol level and the well apparent relationship between the levels of interleukins and IRI. Specifically, the relation between IL-1β and IRI following the application of non-modified yellow clay was characterized as (r=+0.8, p=0.03) in comparison with the relation between IL 6 and IRI (r=+0.8, p=0.03) after the treatment with yellow clay containing 10% of bischofite or between IL 6 and IRI (r=+0.8, p=0.004) after the application of yellow clay containing 20% of bischofite. Conclusion: The results of the study give evidence of the immunomodulatory action of yellow clay modified by the addition of bischofite. They suggest the promising opportunities for the application of these preparations for the management and rehabilitation of the patients presenting with the diseases of the musculoskeletal system in the future. |
| فهرسة مساهمة: | Keywords: adjuvant arthritis; bischofite; yellow clay Local Abstract: [Publisher, Russian] Обоснование. Актуальной задачей курортологии является разработка и изучение влияния препаратов из желтой глины, обогащенной природным минералом бишофит, в целях улучшения ее терапевтического эффекта. Цель исследования - изучить курсовое лечебное воздействие аппликаций желтой глины Пятигорского карьера с добавлением бишофита при адъювантном артрите. Материал и методы. Объектами исследования были 57 половозрелых крыс-самцов линии Вистар. Лечебный курс аппликаций желтой глины с добавлением бишофита различных концентраций (12 процедур по 15 мин через 1-2 дня) начинали с 38-го дня адъювантного артрита. Животных распределили на пять групп. В 1-ю (контрольную) группу вошли здоровые животные без воздействия (n=5). Во 2-5-ю опытные группы включили животных с моделью адъювантного артрита: во 2-ю - без лечения (n=8), в 3-ю - с аппликациями желтой глины без добавок (n=14), в 4-ю - с аппликациями желтой глины с 10% бишофитом (n=15), в 5-ю - с аппликациями желтой глины с 20% бишофитом (n=15). Результаты. После курса аппликаций изучаемых бальнеосредств при адъювантном артрите у животных выявлено снижение реактивно повышенного относительного содержания цитотоксических T-лимфоцитов, активированных Т-клеток, В-лимфоцитов, восстановился до уровня контрольных значений иммунорегуляторный индекс (соотношение T-хелперов и цитотоксических T-лимфоцитов). Наблюдалась зависимость содержания интерлейкина (IL)-1β от уровня кортизола после бальнеопроцедур, а также установлены прямые связи между уровнем IL и иммунорегуляторного индекса (ИРИ). Так, после применения нативной желтой глины установлена связь между IL-1β и ИРИ (r=0,8: p=0,03), после желтой глины с 10% бишофитом - между IL-6 и ИРИ (r=0,8; p=0,03) и после желтой глины с 20% бишофитом - между IL-6 и ИРИ (r=0,8; p=0,004). Заключение. Полученные данные свидетельствуют об иммуномодулирующем действии препаратов из желтой глины с добавлением бишофита. Таким образом, их применение в реабилитации пациентов с заболеваниями опорно-двигательного аппарата является перспективным. |
| المشرفين على المادة: | 0 (Minerals) 0 (bishofit) 02F3473H9O (Magnesium Chloride) T1FAD4SS2M (Clay) |
| تواريخ الأحداث: | Date Created: 20181110 Date Completed: 20190606 Latest Revision: 20190606 |
| رمز التحديث: | 20231215 |
| DOI: | 10.17116/kurort20189505140 |
| PMID: | 30412148 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0042-8787 |
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| DOI: | 10.17116/kurort20189505140 |