دورية أكاديمية
Stable Low Hepatitis C Virus Antibody Prevalence Among HIV-Negative Men Who Have Sex With Men Attending the Sexually Transmitted Infection Outpatient Clinic in Amsterdam, 2007 to 2017.
| العنوان: | Stable Low Hepatitis C Virus Antibody Prevalence Among HIV-Negative Men Who Have Sex With Men Attending the Sexually Transmitted Infection Outpatient Clinic in Amsterdam, 2007 to 2017. |
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| المؤلفون: | Newsum AM, van Rooijen MS, Kroone M, Bruisten SM, Matser A, Hogewoning A, Prins M, Heijman T |
| المصدر: | Sexually transmitted diseases [Sex Transm Dis] 2018 Dec; Vol. 45 (12), pp. 813-817. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: J B Lippincott Country of Publication: United States NLM ID: 7705941 Publication Model: Print Cited Medium: Internet ISSN: 1537-4521 (Electronic) Linking ISSN: 01485717 NLM ISO Abbreviation: Sex Transm Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Philadelphia Pa : J B Lippincott Original Publication: Philadelphia, Lippincott. |
| مواضيع طبية MeSH: | Homosexuality, Male* , Pre-Exposure Prophylaxis*, Hepatitis C/*epidemiology , Hepatitis C/*immunology , Hepatitis C Antibodies/*blood, Adult ; Ambulatory Care Facilities ; Cross-Sectional Studies ; HIV ; HIV Infections/epidemiology ; Hepacivirus/immunology ; Humans ; Male ; Mass Screening ; Middle Aged ; Netherlands/epidemiology ; Prevalence ; Retrospective Studies ; Risk Factors ; Risk-Taking |
| مستخلص: | Background: In response to the increased hepatitis C virus (HCV) prevalence recently found among participants of the Amsterdam preexposure prophylaxis demonstration project, we evaluated HCV prevalence over time and the performance of the HCV-MOSAIC risk score for detection of HCV infection in HIV-negative men who have sex with men (MSM) attending the Amsterdam sexually transmitted infection (STI) clinic. Methods: In October 2016, HIV-negative MSM were tested for anti-HCV and HCV RNA and completed the HCV-MOSAIC risk score. Anti-HCV prevalence was compared with that found in cross-sectional studies at the Amsterdam STI clinic (2007-2017). The time trend in HCV prevalence was modeled via logistic regression. The performance of the HCV-MOSAIC risk score, adjusted to identify prevalent HCV infection, was evaluated by calculating sensitivity and specificity. Results: Of 504 HIV-negative MSM tested in October 2016, 5 were anti-HCV positive (1.0%, 95% confidence interval [CI], 0.4%-2.3%) and all were HCV RNA negative. Sensitivity and specificity of the adjusted HCV-MOSAIC risk score for prevalent infection were 80.0% (95% CI, 37.6%-96.4%) and 56.1% (95% CI, 51.7%-60.4%), respectively. The overall anti-HCV prevalence among 3264 HIV-negative MSM participating in cross-sectional studies at the Amsterdam STI clinic (2007-2017) was 0.8% (95% CI, 0.5%-1.2%) and did not change over time (P = 0.55). Conclusions: Anti-HCV prevalence among HIV-negative MSM attending the Amsterdam STI clinic in October 2016 was 1.0% and remained stable over time. We would therefore not recommend routine HCV screening of HIV-negative MSM at the STI clinic. However, given the increased prevalence among MSM using preexposure prophylaxis, periodic monitoring of HCV prevalence remains important. |
| المشرفين على المادة: | 0 (Hepatitis C Antibodies) |
| تواريخ الأحداث: | Date Created: 20181114 Date Completed: 20190912 Latest Revision: 20190912 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/OLQ.0000000000000877 |
| PMID: | 30422970 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-4521 |
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| DOI: | 10.1097/OLQ.0000000000000877 |