دورية أكاديمية
Insulin Modulates Paracoccidioides brasiliensis -Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs.
العنوان: | Insulin Modulates Paracoccidioides brasiliensis -Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. |
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المؤلفون: | Casagrande FB; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., de Souza Ferreira S; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., Nunes FPB; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., Romera LMD; Laboratory of Mycology, Department of Clinical and Toxicological Analyses, FCF/USP, São Paulo, Brazil., Dos Santos SS; Laboratory of Mycology, Department of Clinical and Toxicological Analyses, FCF/USP, São Paulo, Brazil., Tessaro FHG; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., de Souza PRK; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil.; Universidade Paulista (UNIP), São Paulo, Brazil., Almeida SR; Laboratory of Mycology, Department of Clinical and Toxicological Analyses, FCF/USP, São Paulo, Brazil., Martins JO; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil. |
المصدر: | Journal of diabetes research [J Diabetes Res] 2018 Oct 22; Vol. 2018, pp. 6209694. Date of Electronic Publication: 2018 Oct 22 (Print Publication: 2018). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: <2019>-: London, United Kingdom : Hindawi Limited Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]- |
مواضيع طبية MeSH: | B-Lymphocytes/*drug effects , Dendritic Cells/*drug effects , Hypoglycemic Agents/*therapeutic use , Inflammation/*drug therapy , Insulin/*therapeutic use , Killer Cells, Natural/*drug effects , Lung/*drug effects , Paracoccidioidomycosis/*drug therapy, Animals ; Diabetes Mellitus, Experimental/drug therapy ; Hypoglycemic Agents/pharmacology ; Insulin/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Paracoccidioides |
مستخلص: | Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients. We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis Paracoccidioides brasiliensis (Pb) model. Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments. After 55 days, infected diabetic mice exhibited fewer leukocytes in both peritoneal lavage fluid (PeLF) and bronchoalveolar lavage fluid and reduced secretion of interleukin- (IL-) 6 in lungs. In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. |
References: | Microbes Infect. 2007 Mar;9(3):308-16. (PMID: 17306589) Nat Rev Dis Primers. 2017 Mar 30;3:17016. (PMID: 28358037) Physiol Res. 2001;50(6):537-46. (PMID: 11829314) Microbes Infect. 2006 Mar;8(3):589-97. (PMID: 16500129) Med Mycol. 2005 Dec;43(8):725-9. (PMID: 16422303) Front Immunol. 2017 Aug 21;8:949. (PMID: 28871251) Mycopathologia. 2008 Apr-May;165(4-5):209-21. (PMID: 18777630) Med Mycol. 2000 Feb;38(1):51-60. (PMID: 10746228) Cell Biochem Funct. 1996 Mar;14(1):33-42. (PMID: 8907252) Diabetes Metab Res Rev. 2007 Jan;23(1):3-13. (PMID: 16960917) Am J Trop Med Hyg. 2004 Dec;71(6):828-30. (PMID: 15642978) Cell Microbiol. 2006 Feb;8(2):218-32. (PMID: 16441433) Mycopathologia. 2013 Aug;176(1-2):1-10. (PMID: 23765323) Br J Exp Pathol. 1985 Oct;66(5):585-94. (PMID: 4063162) Microbes Infect. 2007 Jul;9(9):1078-88. (PMID: 17692551) Health Qual Life Outcomes. 2011 Dec 19;9:115. (PMID: 22182307) Diabetes. 2012 Jun;61(6):1584-91. (PMID: 22415874) Nat Immunol. 2007 Jan;8(1):31-8. (PMID: 17159984) Cytokine. 2001 Feb 21;13(4):248-52. (PMID: 11237434) Med Mycol. 2009 May;47(3):259-67. (PMID: 18668419) PLoS Negl Trop Dis. 2011 Oct;5(10):e1353. (PMID: 22039556) Immunity. 2008 Nov 14;29(5):663-5. (PMID: 19006687) Clin Vaccine Immunol. 2012 Jan;19(1):23-9. (PMID: 22089247) J Endocrinol. 2006 Feb;188(2):295-303. (PMID: 16461555) Diabet Med. 1997 Jan;14(1):29-34. (PMID: 9017350) PLoS One. 2011;6(6):e21423. (PMID: 21731741) Int J Exp Pathol. 2011 Dec;92(6):392-9. (PMID: 21950537) N Engl J Med. 1999 Dec 16;341(25):1906-12. (PMID: 10601511) J Interferon Cytokine Res. 2000 Jan;20(1):89-97. (PMID: 10670655) Med Mycol. 2014 Jan;52(1):19-28. (PMID: 23768243) Am J Pathol. 2003 Aug;163(2):583-90. (PMID: 12875978) PLoS One. 2011;6(5):e19690. (PMID: 21611175) |
المشرفين على المادة: | 0 (Hypoglycemic Agents) 0 (Insulin) |
تواريخ الأحداث: | Date Created: 20181115 Date Completed: 20190315 Latest Revision: 20240403 |
رمز التحديث: | 20240403 |
مُعرف محوري في PubMed: | PMC6217756 |
DOI: | 10.1155/2018/6209694 |
PMID: | 30426021 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2314-6753 |
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DOI: | 10.1155/2018/6209694 |