دورية أكاديمية
أعرض في EDS

Insulin Modulates Paracoccidioides brasiliensis -Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs.

التفاصيل البيبلوغرافية
العنوان: Insulin Modulates Paracoccidioides brasiliensis -Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs.
المؤلفون: Casagrande FB; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., de Souza Ferreira S; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., Nunes FPB; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., Romera LMD; Laboratory of Mycology, Department of Clinical and Toxicological Analyses, FCF/USP, São Paulo, Brazil., Dos Santos SS; Laboratory of Mycology, Department of Clinical and Toxicological Analyses, FCF/USP, São Paulo, Brazil., Tessaro FHG; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil., de Souza PRK; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil.; Universidade Paulista (UNIP), São Paulo, Brazil., Almeida SR; Laboratory of Mycology, Department of Clinical and Toxicological Analyses, FCF/USP, São Paulo, Brazil., Martins JO; Laboratory of Immunoendocrinology, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences of University Sao Paulo (FCF/USP), São Paulo, Brazil.
المصدر: Journal of diabetes research [J Diabetes Res] 2018 Oct 22; Vol. 2018, pp. 6209694. Date of Electronic Publication: 2018 Oct 22 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2019>-: London, United Kingdom : Hindawi Limited
Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]-
مواضيع طبية MeSH: B-Lymphocytes/*drug effects , Dendritic Cells/*drug effects , Hypoglycemic Agents/*therapeutic use , Inflammation/*drug therapy , Insulin/*therapeutic use , Killer Cells, Natural/*drug effects , Lung/*drug effects , Paracoccidioidomycosis/*drug therapy, Animals ; Diabetes Mellitus, Experimental/drug therapy ; Hypoglycemic Agents/pharmacology ; Insulin/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Paracoccidioides
مستخلص: Paracoccidioidomycosis, a key issue for Brazilian health service, can be aggravated in patients with impaired immunological responses, such as diabetic patients. We evaluated the role of insulin in inflammatory parameters in diabetic and nondiabetic mice using a systemic mycosis Paracoccidioides brasiliensis (Pb) model. Diabetic C57BL-6 mice and controls were infected with Pb18 and treated with insulin for 12 days prior to experiments. After 55 days, infected diabetic mice exhibited fewer leukocytes in both peritoneal lavage fluid (PeLF) and bronchoalveolar lavage fluid and reduced secretion of interleukin- (IL-) 6 in lungs. In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection.
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المشرفين على المادة: 0 (Hypoglycemic Agents)
0 (Insulin)
تواريخ الأحداث: Date Created: 20181115 Date Completed: 20190315 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC6217756
DOI: 10.1155/2018/6209694
PMID: 30426021
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6753
DOI:10.1155/2018/6209694