دورية أكاديمية
Gas Embolization in a Rodent Model of Hepatocellular Carcinoma Using Acoustic Droplet Vaporization.
| العنوان: | Gas Embolization in a Rodent Model of Hepatocellular Carcinoma Using Acoustic Droplet Vaporization. |
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| المؤلفون: | Harmon JN, Kabinejadian F, Seda R, Fabiilli ML, Kuruvilla SP, Greve JM, Fowlkes BJ, Bull JL |
| المصدر: | Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2018 Jul; Vol. 2018, pp. 6048-6051. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: [IEEE] Country of Publication: United States NLM ID: 101763872 Publication Model: Print Cited Medium: Internet ISSN: 2694-0604 (Electronic) Linking ISSN: 23757477 NLM ISO Abbreviation: Annu Int Conf IEEE Eng Med Biol Soc Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Piscataway, NJ] : [IEEE], [2007]- |
| مواضيع طبية MeSH: | Carcinoma, Hepatocellular* , Embolization, Therapeutic* , Liver Neoplasms*, Animals ; Mice ; Rats ; Rodentia ; Volatilization |
| مستخلص: | Trans-arterial embolization is a commonly used therapy in unresectable hepatocellular carcinoma. Current methods involve the careful placement of an intraarterial catheter and the deposition of embolizing particles. Gas embolotherapy has been proposed as an embolization method with the potential for high spatial resolution without the need for a catheter. This method involves vaporizing intravenouslyadministered droplets into gas bubbles using focused ultrasound - a process termed acoustic droplet vaporization. The bubbles can become lodged in the vasculature, thereby creating an embolus. Here, we initially demonstrate the feasibility of achieving significant targeted embolization with this method in the rat cremaster using intravital microscopy. The therapy was then tested in an ectopic xenograft mouse model of hepatocellular carcinoma. Gas embolotherapy was shown to maintain the tumor volume at baseline over a twoweek treatment course while control groups showed significant tumor growth. These preliminary results demonstrate thatgas embolotherapy could serve as an effective noninvasive method for the management of unresectable hepatocellular carcinoma. |
| References: | Ultrasound Med Biol. 2005 Apr;31(4):553-64. (PMID: 15831334) Am J Pathol. 1954 Sep-Oct;30(5):969-77. (PMID: 13197542) Ultrasound Med Biol. 2000 Sep;26(7):1177-89. (PMID: 11053753) J Acoust Soc Am. 2006 Mar;119(3):1432-40. (PMID: 16583887) Cancer Chemother Pharmacol. 1989;24(3):148-54. (PMID: 2544306) Ultrasound Med Biol. 2003 Oct;29(10):1471-7. (PMID: 14597344) Tex Heart Inst J. 1995;22(2):180-4. (PMID: 7647603) J Control Release. 2009 Sep 15;138(3):268-76. (PMID: 19477208) IEEE Trans Ultrason Ferroelectr Freq Control. 2002 Jun;49(6):726-38. (PMID: 12075966) J Ther Ultrasound. 2017 Jan 24;5:7. (PMID: 28127427) Oncologist. 2003;8(5):425-37. (PMID: 14530495) World J Gastroenterol. 2005 Dec 21;11(47):7391-400. (PMID: 16437707) Semin Intervent Radiol. 2008 Sep;25(3):234-41. (PMID: 21326513) Phys Med Biol. 2013 Sep 7;58(17):6179-91. (PMID: 23948709) Ultrasound Med Biol. 2010 Oct;36(10):1691-703. (PMID: 20800939) Acta Biomater. 2017 Feb;49:472-485. (PMID: 27836803) World J Gastroenterol. 2014 Mar 28;20(12):3069-77. (PMID: 24695579) Microcirculation. 2012 Aug;19(6):501-9. (PMID: 22404846) Pharm Res. 2010 Dec;27(12):2753-65. (PMID: 20872050) Adv Healthc Mater. 2016 Jul;5(14):1764-74. (PMID: 27191532) Ultrasound Med Biol. 1996;22(2):193-201. (PMID: 8735529) J Surg Res. 2016 Feb;200(2):552-9. (PMID: 26507276) Ultrasound Med Biol. 2005 Oct;31(10):1403-10. (PMID: 16223644) Ultrasound Med Biol. 2015 Dec;41(12):3241-52. (PMID: 26403698) Ultrasound Med Biol. 2015 Mar;41(3):814-31. (PMID: 25619781) Appl Phys Lett. 2010 Apr 5;96(14):143702. (PMID: 20448802) Ultrasound Med Biol. 2006 Oct;32(10):1611-9. (PMID: 17045882) World J Hepatol. 2015 May 18;7(8):1020-9. (PMID: 26052391) |
| معلومات مُعتمدة: | R01 EB006476 United States EB NIBIB NIH HHS |
| تواريخ الأحداث: | Date Created: 20181117 Date Completed: 20191106 Latest Revision: 20240712 |
| رمز التحديث: | 20240712 |
| مُعرف محوري في PubMed: | PMC6839763 |
| DOI: | 10.1109/EMBC.2018.8513518 |
| PMID: | 30441715 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2694-0604 |
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| DOI: | 10.1109/EMBC.2018.8513518 |