دورية أكاديمية
Membrane insertion and intercellular transfer of glycosylphosphatidylinositol-anchored proteins: potential therapeutic applications.
| العنوان: | Membrane insertion and intercellular transfer of glycosylphosphatidylinositol-anchored proteins: potential therapeutic applications. |
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| المؤلفون: | Müller GA; Helmholtz Diabetes Center (HDC) at the Helmholtz Center München, Institute for Diabetes and Obesity, Oberschleissheim, Germany.; Department Biology I, Genetics, Ludwig-Maximilians-University München, Planegg-Martinsried, Germany. |
| المصدر: | Archives of physiology and biochemistry [Arch Physiol Biochem] 2020 May; Vol. 126 (2), pp. 139-156. Date of Electronic Publication: 2018 Nov 16. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9510153 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4160 (Electronic) Linking ISSN: 13813455 NLM ISO Abbreviation: Arch Physiol Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995- |
| مواضيع طبية MeSH: | Cell Engineering/*methods , Glycosylphosphatidylinositols/*metabolism , Lipid-Linked Proteins/*therapeutic use , Metabolic Diseases/*therapy , Neoplasms/*therapy , Prion Diseases/*therapy, Blood Coagulation Disorders/therapy ; Cell Membrane/chemistry ; Cell Membrane/metabolism ; Eukaryotic Cells/cytology ; Eukaryotic Cells/metabolism ; Glycosylphosphatidylinositols/chemistry ; Hemoglobinuria, Paroxysmal/therapy ; Humans ; Immunotherapy/methods ; Lipid-Linked Proteins/chemistry ; Lipid-Linked Proteins/metabolism ; Protein Transport ; Reproductive Techniques, Assisted ; T-Lymphocytes, Cytotoxic/cytology ; T-Lymphocytes, Cytotoxic/immunology |
| مستخلص: | Anchorage of a subset of cell surface proteins in eukaryotic cells is mediated by a glycosylphosphatidylinositol (GPI) moiety covalently attached to the carboxy-terminus of the protein moiety. Experimental evidence for the potential of GPI-anchored proteins (GPI-AP) of being released from cells into the extracellular environment has been accumulating, which involves either the loss or retention of the GPI anchor. Release of GPI-AP from donor cells may occur spontaneously or in response to endogenous or environmental signals. The experimental evidence for direct insertion of exogenous GPI-AP equipped with the complete anchor structure into the outer plasma membrane bilayer leaflets of acceptor cells is reviewed as well as the potential underlying molecular mechanisms. Furthermore, promiscuous transfer of certain GPI-AP between plasma membranes of different cells in vivo under certain (patho)physiological conditions has been reported. Engineering of target cell surfaces using chimeric GPI-AP with complete GPI anchor may be useful for therapeutic applications. |
| فهرسة مساهمة: | Keywords: Cellular painting; GPI; cell surface engineering; glycosylphosphatidylinositol; glycosylphosphatidylinositol-anchored proteins; intercellular transfer of membrane proteins; protein transduction |
| المشرفين على المادة: | 0 (Glycosylphosphatidylinositols) 0 (Lipid-Linked Proteins) |
| تواريخ الأحداث: | Date Created: 20181118 Date Completed: 20200323 Latest Revision: 20200323 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/13813455.2018.1498904 |
| PMID: | 30445857 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1744-4160 |
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| DOI: | 10.1080/13813455.2018.1498904 |