دورية أكاديمية
أعرض في EDS

Outbreak of Crimean-Congo haemorrhagic fever with atypical clinical presentation in the Karak District of Khyber Pakhtunkhwa, Pakistan.

التفاصيل البيبلوغرافية
العنوان: Outbreak of Crimean-Congo haemorrhagic fever with atypical clinical presentation in the Karak District of Khyber Pakhtunkhwa, Pakistan.
المؤلفون: Rehman K; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria., Bettani MAK; Department of health Khyber Pakhtunkhwa, Gate # 5 opposite Pearl Continental hotel Main GT road Peshawar, Peshawar, 25000, Pakistan., Veletzky L; Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I Department of Medicine, University Medical Center Hamburg-Eppendorf, Bernhard-Nocht-Straße 74, 20359, Hamburg, Germany., Afridi S; Department of health Khyber Pakhtunkhwa, Gate # 5 opposite Pearl Continental hotel Main GT road Peshawar, Peshawar, 25000, Pakistan., Ramharter M; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I Department of Medicine, University Medical Center Hamburg-Eppendorf, Bernhard-Nocht-Straße 74, 20359, Hamburg, Germany. ramharter@bnitm.de.
المصدر: Infectious diseases of poverty [Infect Dis Poverty] 2018 Nov 19; Vol. 7 (1), pp. 116. Date of Electronic Publication: 2018 Nov 19.
نوع المنشور: Case Reports; Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101606645 Publication Model: Electronic Cited Medium: Internet ISSN: 2049-9957 (Electronic) Linking ISSN: 20499957 NLM ISO Abbreviation: Infect Dis Poverty Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, 2012-
مواضيع طبية MeSH: Contact Tracing* , Disease Outbreaks*, Hemorrhagic Fever Virus, Crimean-Congo/*isolation & purification , Hemorrhagic Fever, Crimean/*epidemiology, Adolescent ; Adult ; Agriculture ; Animals ; Cattle/virology ; Cross Infection/epidemiology ; Cross Infection/virology ; Fatal Outcome ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/virology ; Hemorrhagic Fever Virus, Crimean-Congo/genetics ; Hemorrhagic Fever, Crimean/diagnosis ; Hospitals ; Humans ; Livestock/virology ; Male ; Middle Aged ; Pakistan/epidemiology ; Polymerase Chain Reaction ; Real-Time Polymerase Chain Reaction ; Ticks/virology
مستخلص: Background: Crimean-Congo haemorrhagic fever (CCHF) is a potentially fatal disease endemic in Pakistan. The causative virus is transmitted by the bite of Hyalomma ticks or by contact with infected blood or tissue. First cases of the disease were reported in Pakistan in 1976 but regular outbreaks have been observed since the year 2000. A huge agricultural base with more than 175 million livestock, the concomitant presence of Hyalomma ticks and a lack of precautionary measures to prevent transmission lead to a considerable risk for exposed populations to contract CCHF in Pakistan. At the same time, secondary cases contracted by nosocomial transmission are reported from hospitals.
Case Presentation: Here we present an outbreak of CCHF with four of six patients succumbing to the disease before the suspicion for CCHF was raised. Importantly, the main clinical features of these cases were gastrointestinal symptoms without any clinical signs of bleeding. Only the last two patients in this outbreak presented with typical signs of bleeding disorder and were then confirmed being infected by CCHF. Confirmation of diagnosis was done at the National Institute of Health by real-time RT-PCR.
Conclusions: This case series highlights the importance of early clinical suspicion for CCHF in exposed individuals and the need for improved precautionary measures against the spread of CCHF within the Pakistani population and hospitals.
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فهرسة مساهمة: Keywords: Contact tracing; Crimean Congo haemorrhagic fever; GI symptoms; Outbreak
تواريخ الأحداث: Date Created: 20181120 Date Completed: 20190211 Latest Revision: 20190215
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6240963
DOI: 10.1186/s40249-018-0499-z
PMID: 30449274
قاعدة البيانات: MEDLINE
الوصف
تدمد:2049-9957
DOI:10.1186/s40249-018-0499-z