دورية أكاديمية
The role of symptoms and insight in mediating cognition and functioning in first episode psychosis.
| العنوان: | The role of symptoms and insight in mediating cognition and functioning in first episode psychosis. |
|---|---|
| المؤلفون: | Lee EHM; Department of Psychiatry, University of Hong Kong, Hong Kong. Electronic address: edwinlhm@hku.hk., Hui CLM; Department of Psychiatry, University of Hong Kong, Hong Kong., Chan KPK; Department of Psychiatry, University of Hong Kong, Hong Kong., Chan PY; Department of Psychiatry, University of Hong Kong, Hong Kong., Law EYL; Department of Psychiatry, University of Hong Kong, Hong Kong., Chong CSY; Department of Psychiatry, Kwai Chung Hospital, Hong Kong., Chang WC; Department of Psychiatry, University of Hong Kong, Hong Kong; State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong., Chan SKW; Department of Psychiatry, University of Hong Kong, Hong Kong; State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong., Lee WK; Department of Psychiatry, Kwai Chung Hospital, Hong Kong., Lo AWF; Department of Psychiatry, Kwai Chung Hospital, Hong Kong., Pang EPF; Department of Psychiatry, United Christian Hospital, Hong Kong., Cheung EFC; Department of Psychiatry, Castle Peak Hospital, Hong Kong., Yiu MGC; Department of Psychiatry, United Christian Hospital, Hong Kong., Chung DWS; Department of Psychiatry, Tai Po Hospital, Hong Kong., Ng RMK; Department of Psychiatry, Kowloon Hospital, Hong Kong., Yeung WS; Department of Psychiatry, Pamela Youde Nethersole Eastern Hospital, Hong Kong., Lo WTL; Department of Psychiatry, Kwai Chung Hospital, Hong Kong., Chen EYH; Department of Psychiatry, University of Hong Kong, Hong Kong; State Key Laboratory of Brain and Cognitive Sciences, University of Hong Kong, Hong Kong. |
| المصدر: | Schizophrenia research [Schizophr Res] 2019 Apr; Vol. 206, pp. 251-256. Date of Electronic Publication: 2018 Nov 16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publisher B. V Country of Publication: Netherlands NLM ID: 8804207 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2509 (Electronic) Linking ISSN: 09209964 NLM ISO Abbreviation: Schizophr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publisher B. V., c1988- |
| مواضيع طبية MeSH: | Awareness/*physiology , Cognitive Dysfunction/*physiopathology , Psychotic Disorders/*physiopathology , Schizophrenia/*physiopathology, Adult ; Cognitive Dysfunction/etiology ; Female ; Follow-Up Studies ; Humans ; Male ; Psychotic Disorders/complications ; Schizophrenia/complications |
| مستخلص: | Introduction: Achieving functional recovery in patients with psychosis is a challenge in clinical practice. Investigating the complex interplay between cognition, symptoms, insight and functional outcome in first episode psychosis will be crucial to understanding the factors leading to better functioning. Methods: In this 12-month prospective follow-up study, we investigated how cognition, clinical symptoms, and insight into illness affected overall functioning in 160 patients with first episode psychosis recruited from the Early Assessment Service for Young People with Psychosis (EASY) in Hong Kong from July 1, 2014 to June 30, 2016. Cognition was assessed at baseline while symptoms, insight, and functioning were assessed at 12-month follow-up. Structural equation modelling was used to examine the direct and indirect relationships between functioning and other latent constructs. Results: Symptoms (negative symptoms and general psychopathology) and insight were shown to be significant mediators between cognition and functioning. The significant direct relationship between cognition and functioning (β = 0.387; p < 0.001) became insignificant (β = 0.079; p = 0.578) after including symptoms and insight in the model. Symptoms and insight were significantly associated with cognition (symptoms, β = -0.469; p < 0.001; insight, β = -0.372; p < 0.001) and predicted functioning (symptoms, β = -0.558; p < 0.001; insight, β = -0.264; p < 0.01). Conclusion: Symptoms and insight mediated the effects of cognition on functioning. Interventions for improving functioning in patients with first episode psychosis should target not only cognition but also symptoms and insight. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cognition; First episode psychosis; Functioning; Mediators |
| تواريخ الأحداث: | Date Created: 20181120 Date Completed: 20200519 Latest Revision: 20200519 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.schres.2018.11.009 |
| PMID: | 30449592 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1573-2509 |
|---|---|
| DOI: | 10.1016/j.schres.2018.11.009 |