دورية أكاديمية
أعرض في EDS

Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure.

التفاصيل البيبلوغرافية
العنوان: Intravenous Infusion of the Novel HNO Donor BMS-986231 Is Associated With Beneficial Inotropic, Lusitropic, and Vasodilatory Properties in 2 Canine Models of Heart Failure.
المؤلفون: Hartman JC; Pharmaceutical R&D Consulting, LLC, Loveland, Colorado., Del Rio CL; QTest Labs, LLC, Columbus, Ohio., Reardon JE; Revivo Therapeutics, Inc., Durham, North Carolina., Zhang K; Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, Michigan., Sabbah HN; Department of Medicine, Division of Cardiovascular Medicine, Henry Ford Hospital, Detroit, Michigan.
المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2018 Nov 12; Vol. 3 (5), pp. 625-638. Date of Electronic Publication: 2018 Nov 12 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [New York] : Elsevier on behalf of the American College of Cardiology Foundation, [2016]-
مستخلص: The effects of the nitroxyl donor BMS-986231 on hemodynamics, left ventricular (LV) function, and pro-arrhythmic potential were assessed using canine heart failure models. BMS-986231 significantly (p < 0.05) increased LV end-systolic elastance, pre-load-recruitable stroke work, ejection fraction, stroke volume, cardiac output, ratio of early-to-late filling time integrals, and early mitral valve inflow velocity deceleration time. BMS-986231 significantly decreased LV filling pressures, end-diastolic stiffness, the time-constant of relaxation, end-diastolic wall stress, systemic vascular resistance, and myocardial oxygen consumption. BMS-986231 had little effect on heart rate and did not induce de novo arrhythmias. Thus, BMS-986231 has beneficial inotropic, lusitropic, and vasodilatory effects.
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فهرسة مساهمة: Keywords: DT, deceleration time of early mitral inflow velocity; EDPVR, end-diastolic pressure–volume relationship; ESPVR, end-systolic pressure–volume relationship; Ei/Ai, the ratio of early-to-late filling time integrals; HEX, Hextend (plasma volume-expanding solution); LVEDWS, left ventricular end-diastolic circumferential wall stress; LVEF, left ventricular ejection fraction; LVFAS, left ventricular fractional area shortening; MHC, myosin heavy chain; MLC1, myosin light chain 1; PRSW, pre-load-recruitable stroke work; RyR2, ryanodine receptor 2; SH, thiol group; SV, stroke volume; SVR, systemic vascular resistance; Tau, left ventricular relaxation time-constant; canine; cardiomyopathies; heart failure; hemodynamics; nitroxyl
تواريخ الأحداث: Date Created: 20181121 Latest Revision: 20231004
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6234500
DOI: 10.1016/j.jacbts.2018.07.003
PMID: 30456334
قاعدة البيانات: MEDLINE
الوصف
تدمد:2452-302X
DOI:10.1016/j.jacbts.2018.07.003