دورية أكاديمية
أعرض في EDS

Increased in vitro leishmanicidal activity of octyl gallate loaded poly(methyl methacrylate) nanoparticles.

التفاصيل البيبلوغرافية
العنوان: Increased in vitro leishmanicidal activity of octyl gallate loaded poly(methyl methacrylate) nanoparticles.
المؤلفون: Feuser PE; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil., Tonini ML; b Department of Microbiology Immunology and Parasitology , Federal University of Santa Catarina , Florianópolis , Brazil.; c Biomedical Sciences Research Complex , University of St Andrews , Fife , UK., Jacques AV; d Department of Clinical Analyses , Federal University of Santa Catarina , Florianópolis , Brazil., Santos da Silva MC; d Department of Clinical Analyses , Federal University of Santa Catarina , Florianópolis , Brazil., Steindel M; b Department of Microbiology Immunology and Parasitology , Federal University of Santa Catarina , Florianópolis , Brazil., Sayer C; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil., Hermes de Araújo PH; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.
المصدر: Pharmaceutical development and technology [Pharm Dev Technol] 2019 Jun; Vol. 24 (5), pp. 593-599.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9610932 Publication Model: Print Cited Medium: Internet ISSN: 1097-9867 (Electronic) Linking ISSN: 10837450 NLM ISO Abbreviation: Pharm Dev Technol
أسماء مطبوعة: Publication: London : Informa Healthcare
Original Publication: Monticello, NY : Marcel Dekker, c1996-
مواضيع طبية MeSH: Drug Carriers/*chemistry , Gallic Acid/*analogs & derivatives , Leishmania/*drug effects , Polymethyl Methacrylate/*chemistry , Trypanocidal Agents/*administration & dosage , Trypanocidal Agents/*pharmacology, Caco-2 Cells ; Cell Line ; Drug Liberation ; Emulsions/chemistry ; Gallic Acid/administration & dosage ; Gallic Acid/chemistry ; Gallic Acid/pharmacology ; Hemolysis/drug effects ; Humans ; Leishmaniasis/drug therapy ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Trypanocidal Agents/chemistry
مستخلص: The current paucity of effective and affordable drugs for the treatment of leishmaniasis renders the search for new therapeutic alternatives a priority. Gallic acid-related compounds display anti-parasitic activities and their incorporation into drug carrier systems, such as polymeric nanoparticles may be a viable alternative for leishmaniasis treatment. Therefore, this study focused on the synthesis and characterization of octyl gallate (G8) loaded poly(methyl methacrylate) (PMMA) nanoparticles via miniemulsion polymerization in order to increase the leishmanicidal activity of this compound. G8 loaded PMMA nanoparticles presented a spherical morphology with a mean size of 108 nm, a negatively charged surface (-33 ± 5 mV) and high encapsulation efficiency (83% ± 5). Fourier-transform infrared spectroscopy and X-ray diffraction analysis confirmed that G8 was encapsulated in PMMA nanoparticles and presented a biphasic release profile. The G8 loaded PMMA nanoparticles did not present cytotoxic effect on human red blood cells. G8 loaded PMMA nanoparticles displayed a leishmanicidal activity almost three times higher than free G8 while the cytotoxic activity against human THP-1 cells remained unchanged.
فهرسة مساهمة: Keywords: ; Octyl gallate; miniemulsion polymerization; poly(methyl methacrylate); polymeric nanoparticles
المشرفين على المادة: 0 (Drug Carriers)
0 (Emulsions)
0 (Trypanocidal Agents)
079IIA2811 (octyl gallate)
632XD903SP (Gallic Acid)
9011-14-7 (Polymethyl Methacrylate)
تواريخ الأحداث: Date Created: 20181121 Date Completed: 20190813 Latest Revision: 20190813
رمز التحديث: 20231215
DOI: 10.1080/10837450.2018.1547747
PMID: 30457422
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-9867
DOI:10.1080/10837450.2018.1547747