دورية أكاديمية
أعرض في EDS

Evaluation of hematological, biochemical parameters and thiol enzyme activity in chrome plating workers.

التفاصيل البيبلوغرافية
العنوان: Evaluation of hematological, biochemical parameters and thiol enzyme activity in chrome plating workers.
المؤلفون: Lacerda LM; Environmental Quality Post-Graduation Program, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil., Garcia SC; Laboratory of Toxicology (LATOX), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., da Silva LB; Environmental Quality Post-Graduation Program, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil., de Ávila Dornelles M; Health Sciences Institute, Feevale University, Novo Hamburgo, RS, Brazil., Presotto AT; Health Sciences Institute, Feevale University, Novo Hamburgo, RS, Brazil., Lourenço ED; Health Sciences Institute, Feevale University, Novo Hamburgo, RS, Brazil., de Franceschi ID; Biochemistry Department, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Fernandes E; Biochemistry Department, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Wannmacher CMD; Biochemistry Department, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Brucker N; Department of Physiology and Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil., Sauer E; Laboratory of Toxicology (LATOX), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil., Gioda A; Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro, RJ, Brazil., Machado AB; Environmental Quality Post-Graduation Program, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil. linebmachado@hotmail.com.; Health Sciences Institute, Feevale University, Novo Hamburgo, RS, Brazil. linebmachado@hotmail.com., Oliveira E; Environmental Quality Post-Graduation Program, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil., Trombini TL; Environmental Quality Post-Graduation Program, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil., Feksa LR; Environmental Quality Post-Graduation Program, Feevale University, ERS 239, 2755, Novo Hamburgo, RS, 93525-075, Brazil.; Laboratory of Toxicology (LATOX), Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.; Health Sciences Institute, Feevale University, Novo Hamburgo, RS, Brazil.; Biochemistry Department, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
المصدر: Environmental science and pollution research international [Environ Sci Pollut Res Int] 2019 Jan; Vol. 26 (2), pp. 1892-1901. Date of Electronic Publication: 2018 Nov 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE
أسماء مطبوعة: Publication: <2013->: Berlin : Springer
Original Publication: Landsberg, Germany : Ecomed
مواضيع طبية MeSH: Biomarkers/*metabolism , Occupational Exposure/*statistics & numerical data , Sulfhydryl Compounds/*metabolism, Adult ; Biometry ; Chromium ; Ecotoxicology ; Humans ; Male
مستخلص: The most commonly used solution in chrome plating bath is chromic acid (hexavalent Cr), and a considerable amount of mists is released into the air and consequently produce hazards to workers. Thus, the aim of this study was to evaluate whether the biomarker of exposure to metals, specially Cr levels, presents associations with hematological and biochemical parameters and if they can alter the activity of enzymes that contain thiol groups such as pyruvate kinase, creatine kinase, adenylate kinase, and δ-aminolevulinate dehydratase. Fifty male chrome plating workers were used for exposed group and 50 male non-exposed workers for control group. For that, biological monitoring was performed through quantification of metals on total blood and urine by inductively coupled plasma mass spectrometry (ICP-MS) and enzyme activity was performed by spectrometry in erythrocytes. In addition, chromium levels in water was quantified and ecotoxicology assay was performed with Allium cepa test. The results demonstrated that blood and urinary chromium levels in exposed group were higher than the control group (p < 0.0001). Furthermore, decreased activity of enzymes was found in those that contain thiol groups from exposed group when compared with the control group (p < 0.001). The water analysis did not present a statistical difference between control and exposed groups (p > 0.05), demonstrating that water did not seem to be the source of contamination. In summary, our findings indicated some toxicology effects observed in the exposed group, such as thiol enzyme inhibition, mainly associated with occupational exposure in chrome plating and besides the presence of other metals, and Cr demonstrated to influence the activity of the enzymes analyzed in this research.
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فهرسة مساهمة: Keywords: Biomonitoring; Chromium; Occupational exposure; Thiol-containing enzymes; Water
المشرفين على المادة: 0 (Biomarkers)
0 (Sulfhydryl Compounds)
0R0008Q3JB (Chromium)
تواريخ الأحداث: Date Created: 20181122 Date Completed: 20190214 Latest Revision: 20200225
رمز التحديث: 20240628
DOI: 10.1007/s11356-018-3755-7
PMID: 30460648
قاعدة البيانات: MEDLINE
الوصف
تدمد:1614-7499
DOI:10.1007/s11356-018-3755-7