دورية أكاديمية
Regenerating infected bone defects with osteocompatible microspheres possessing antibacterial activity.
| العنوان: | Regenerating infected bone defects with osteocompatible microspheres possessing antibacterial activity. |
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| المؤلفون: | Wei PF; State Key Laboratory of Organic-Inorganic Composites; Beijing Laboratory of Biomedical Materials; Beijing University of Chemical Technology, Beijing 100029, P.R. China. caiqing@mail.buct.edu.cn yangxp@mail.buct.edu.cn., Yuan ZY, Jing W, Guan BB, Liu ZH, Zhang X, Mao JP, Chen DF, Cai Q, Yang XP |
| المصدر: | Biomaterials science [Biomater Sci] 2018 Dec 18; Vol. 7 (1), pp. 272-286. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101593571 Publication Model: Print Cited Medium: Internet ISSN: 2047-4849 (Electronic) Linking ISSN: 20474830 NLM ISO Abbreviation: Biomater Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, UK : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*therapeutic use , Apatites/*therapeutic use , Bone Regeneration/*drug effects , Coated Materials, Biocompatible/*therapeutic use , Silver/*therapeutic use , Staphylococcal Infections/*drug therapy , Staphylococcus aureus/*drug effects, Animals ; Anti-Bacterial Agents/pharmacology ; Apatites/pharmacology ; Cell Line ; Coated Materials, Biocompatible/pharmacology ; Indoles/pharmacology ; Indoles/therapeutic use ; Microspheres ; Osteogenesis/drug effects ; Polymers/pharmacology ; Polymers/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Silver/pharmacology ; Skull/drug effects ; Skull/injuries ; Skull/microbiology |
| مستخلص: | Treatment of infected bone defects still remains a formidable clinical challenge, and the design of bone implants with both anti-bacterial activity and -osteogenesis effects is nowadays regarded as a powerful strategy for infection control and bone healing. In the present study, bioresorbable porous-structured microspheres were fabricated from an amphiphilic block copolymer composed of poly(l-lactide) and poly(ethyl glycol) blocks. After being surface coated with mussel-inspired polydopamine, the microspheres were loaded with nanosilver via the reduction of silver nitrate and apatite via biomineralization in sequence. At optimized loading amounts, the nanosilver-loaded microspheres showed no unfavorable effects on the proliferation and differentiation of bone marrow mesenchymal stem cells despite preserving strong antibacterial activity in in vitro evaluations. For the critical-sized defects (φ = 8 mm) in the rat cranium that was pre-infected with Staphylococcus aureus, the filling of the dual-purpose microspheres demonstrated an effective way to kill bacteria in vivo, and in the meantime, it promoted new bone formation efficiently alongside the degradation of microspheres. Thus, the results suggested that bioresorbable microspheres with both osteoconductive and antibacterial activities were a good choice for treating infected bone defects. |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Apatites) 0 (Coated Materials, Biocompatible) 0 (Indoles) 0 (Polymers) 0 (polydopamine) 3M4G523W1G (Silver) |
| تواريخ الأحداث: | Date Created: 20181124 Date Completed: 20190401 Latest Revision: 20190401 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1039/c8bm00903a |
| PMID: | 30467569 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2047-4849 |
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| DOI: | 10.1039/c8bm00903a |