دورية أكاديمية
Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial.
| العنوان: | Could resistant starch supplementation improve inflammatory and oxidative stress biomarkers and uremic toxins levels in hemodialysis patients? A pilot randomized controlled trial. |
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| المؤلفون: | Esgalhado M; Post-Graduate Program in Cardiovascular Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil. martaesgalhado@hotmail.com., Kemp JA, Azevedo R, Paiva BR, Stockler-Pinto MB, Dolenga CJ, Borges NA, Nakao LS, Mafra D |
| المصدر: | Food & function [Food Funct] 2018 Dec 13; Vol. 9 (12), pp. 6508-6516. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Cresols/*urine , Indican/*urine , Oxidative Stress/*drug effects , Prebiotics/*administration & dosage , Renal Insufficiency, Chronic/*diet therapy , Starch/*metabolism , Sulfuric Acid Esters/*urine, Adult ; Anthropometry ; Biomarkers/blood ; Biomarkers/urine ; C-Reactive Protein/metabolism ; Female ; Humans ; Interleukin-6/blood ; Male ; Middle Aged ; Pilot Projects ; Renal Dialysis ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/therapy ; Renal Insufficiency, Chronic/urine ; Thiobarbituric Acid Reactive Substances/metabolism ; Urine/chemistry ; Zea mays/chemistry ; Zea mays/metabolism |
| مستخلص: | An imbalance of gut microbiota is considered a new cardiovascular risk factor for chronic kidney disease (CKD) patients, since it is directly associated with increased uremic toxin production, inflammation and oxidative stress. Strategies such as prebiotic supplementation have been suggested to mitigate these complications. We hypothesized that prebiotic-resistant starch could ameliorate uremic toxins levels, oxidative stress, and inflammatory states in hemodialysis (HD) patients. This pilot study evaluated 31 HD patients assigned to either resistant starch (16 g of resistant starch Hi-Maize® 260) or placebo (manioc flour) supplementation, which they received for 4 weeks on alternate days through cookies on dialysis days and powder in a sachet on non-dialysis days. Levels of interleukin (IL)-6, high-sensitive C-reactive protein, thiobarbituric acid reactive substances plasma (TBARS), protein carbonylation, indoxyl sulfate (IS) and p-cresyl sulfate were measured. Anthropometric and biochemical parameters, as well as, food intake were also evaluated. As expected, resistant starch group increased fiber intake (p > 0.01), in addition the prebiotic supplementation reduced IL-6 (p = 0.01), TBARS (p > 0.01), and IS (p > 0.01) plasma levels. No significant differences were evident in the placebo group. Prebiotic-resistant starch supplementation seems to be a promising nutritional strategy to improve inflammation, oxidative stress and to reduce IS plasma levels in CKD patients on HD. |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cresols) 0 (Interleukin-6) 0 (Prebiotics) 0 (Sulfuric Acid Esters) 0 (Thiobarbituric Acid Reactive Substances) 56M34ZQY1S (4-cresol sulfate) 9005-25-8 (Starch) 9007-41-4 (C-Reactive Protein) N187WK1Y1J (Indican) |
| تواريخ الأحداث: | Date Created: 20181124 Date Completed: 20190403 Latest Revision: 20190403 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1039/c8fo01876f |
| PMID: | 30468238 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
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| DOI: | 10.1039/c8fo01876f |