دورية أكاديمية
Six-Month Assessment of a Hand Prosthesis with Intraneural Tactile Feedback.
| العنوان: | Six-Month Assessment of a Hand Prosthesis with Intraneural Tactile Feedback. |
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| المؤلفون: | Petrini FM; Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland., Valle G; Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland.; Biorobotics Institute, Sant'Anna School of Advanced Studies (SSSA), Pisa, Italy., Strauss I; Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland.; Biorobotics Institute, Sant'Anna School of Advanced Studies (SSSA), Pisa, Italy., Granata G; Institute of Neurology, Catholic University, Rome, Italy.; Department of Geriatrics, Neuroscience, and Orthopedics, Policlinic A. Gemelli Foundation-IRCCS, Rome, Italy., Di Iorio R; Institute of Neurology, Catholic University, Rome, Italy.; Department of Geriatrics, Neuroscience, and Orthopedics, Policlinic A. Gemelli Foundation-IRCCS, Rome, Italy., D'Anna E; Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland., Čvančara P; Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, Bernstein Center Freiburg and BrainLinks-BrainTools Center, University of Freiburg, Freiburg, Germany., Mueller M; Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, Bernstein Center Freiburg and BrainLinks-BrainTools Center, University of Freiburg, Freiburg, Germany., Carpaneto J; Biorobotics Institute, Sant'Anna School of Advanced Studies (SSSA), Pisa, Italy., Clemente F; Biorobotics Institute, Sant'Anna School of Advanced Studies (SSSA), Pisa, Italy., Controzzi M; Biorobotics Institute, Sant'Anna School of Advanced Studies (SSSA), Pisa, Italy., Bisoni L; Department of Electrical and Electronic Engineering, University of Cagliari, Cagliari, Italy., Carboni C; Department of Electrical and Electronic Engineering, University of Cagliari, Cagliari, Italy., Barbaro M; Department of Electrical and Electronic Engineering, University of Cagliari, Cagliari, Italy., Iodice F; Institute of Neurology, Catholic University, Rome, Italy.; Department of Geriatrics, Neuroscience, and Orthopedics, Policlinic A. Gemelli Foundation-IRCCS, Rome, Italy., Andreu D; INRIA, CAMIN Team, University of Montpellier, Montpellier, France., Hiairrassary A; INRIA, CAMIN Team, University of Montpellier, Montpellier, France., Divoux JL; Axonic, Vallauris, France., Cipriani C; Biorobotics Institute, Sant'Anna School of Advanced Studies (SSSA), Pisa, Italy., Guiraud D; INRIA, CAMIN Team, University of Montpellier, Montpellier, France., Raffo L; Department of Electrical and Electronic Engineering, University of Cagliari, Cagliari, Italy., Fernandez E; Institute of Neurology, Catholic University, Rome, Italy.; Department of Geriatrics, Neuroscience, and Orthopedics, Policlinic A. Gemelli Foundation-IRCCS, Rome, Italy., Stieglitz T; Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, Bernstein Center Freiburg and BrainLinks-BrainTools Center, University of Freiburg, Freiburg, Germany., Raspopovic S; Laboratory for Neuroengineering, Department of Health Sciences and Technology, Institute for Robotics and Intelligent Systems, ETH Zürich, Zürich, Switzerland., Rossini PM; Institute of Neurology, Catholic University, Rome, Italy.; Department of Geriatrics, Neuroscience, and Orthopedics, Policlinic A. Gemelli Foundation-IRCCS, Rome, Italy., Micera S; Bertarelli Foundation Chair in Translational Neuroengineering, Center for Neuroprosthetics and Institute of Bioengineering, School of Engineering, Swiss Federal Institute of Technology of Lausanne (EPFL), Lausanne, Switzerland.; Biorobotics Institute, Sant'Anna School of Advanced Studies (SSSA), Pisa, Italy. |
| المصدر: | Annals of neurology [Ann Neurol] 2019 Jan; Vol. 85 (1), pp. 137-154. Date of Electronic Publication: 2018 Dec 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 7707449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-8249 (Electronic) Linking ISSN: 03645134 NLM ISO Abbreviation: Ann Neurol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Wiley-Liss Original Publication: Boston, Little, Brown. |
| مواضيع طبية MeSH: | Artificial Limbs* , Implantable Neurostimulators*, Amputation, Traumatic/*rehabilitation , Feedback, Sensory/*physiology , Hand/*physiology , Touch/*physiology, Adult ; Amputation, Traumatic/physiopathology ; Female ; Hand/innervation ; Humans ; Male ; Middle Aged ; Time Factors |
| مستخلص: | Objective: Hand amputation is a highly disabling event, which significantly affects quality of life. An effective hand replacement can be achieved if the user, in addition to motor functions, is provided with the sensations that are naturally perceived while grasping and moving. Intraneural peripheral electrodes have shown promising results toward the restoration of the sense of touch. However, the long-term usability and clinical relevance of intraneural sensory feedback have not yet been clearly demonstrated. Methods: To this aim, we performed a 6-month clinical study with 3 transradial amputees who received implants of transverse intrafascicular multichannel electrodes (TIMEs) in their median and ulnar nerves. After calibration, electrical stimulation was delivered through the TIMEs connected to artificial sensors in the digits of a prosthesis to generate sensory feedback, which was then used by the subjects while performing different grasping tasks. Results: All subjects, notwithstanding their important clinical differences, reported stimulation-induced sensations from the phantom hand for the whole duration of the trial. They also successfully integrated the sensory feedback into their motor control strategies while performing experimental tests simulating tasks of real life (with and without the support of vision). Finally, they reported a decrement of their phantom limb pain and a general improvement in mood state. Interpretation: The promising results achieved with all subjects show the feasibility of the use of intraneural stimulation in clinical settings. ANN NEUROL 2019;85:137-154. (© 2018 American Neurological Association.) |
| التعليقات: | Comment in: Nat Rev Neurol. 2019 Jan;15(1):2. (PMID: 30542074) |
| معلومات مُعتمدة: | CP-FP-INFSO 224012 FP7-611687 International European Commission; International Bertarelli Foundation; Switzerland SNSF_ Swiss National Science Foundation; NEMESIS International Italian Ministry of Health |
| تواريخ الأحداث: | Date Created: 20181127 Date Completed: 20191125 Latest Revision: 20191125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1002/ana.25384 |
| PMID: | 30474259 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1531-8249 |
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| DOI: | 10.1002/ana.25384 |