دورية أكاديمية
Association between serum progesterone concentration in early pregnancy and duration of pregnancy: a cohort study.
| العنوان: | Association between serum progesterone concentration in early pregnancy and duration of pregnancy: a cohort study. |
|---|---|
| المؤلفون: | Shen SY; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Chen QZ; Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Zhang LF; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Department of Woman and Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., He JR; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Department of Woman and Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Lu JH; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Department of Woman and Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Li WD; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Department of Woman and Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Xiao WQ; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Department of Woman and Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Zhou ZH; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Morse AN; Urogynecology and OBGYN Academic Program Development, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Keung Cheng K; Institute of Applied Health Research, University of Birmingham, Birmingham, UK., Mol BWJ; Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia., Xia HM; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Department of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Qiu X; Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.; Department of Woman and Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China. |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2020 Jun; Vol. 33 (12), pp. 2096-2102. Date of Electronic Publication: 2018 Nov 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Pregnancy/*physiology , Progesterone/*blood, Adult ; Case-Control Studies ; Causality ; Female ; Gestational Age ; Humans ; Infant, Newborn ; Pregnancy/blood ; Pregnancy Trimester, First/blood ; Premature Birth/blood ; Premature Birth/epidemiology ; Proportional Hazards Models ; Prospective Studies ; Surveys and Questionnaires |
| مستخلص: | Objective: To examine the association between progesterone concentration in early pregnancy and duration of pregnancy and risk of preterm delivery. Methods: Women enrolled in the Born in Guangzhou Cohort Study from 2013-2014, with a singleton pregnancy, who had serum progesterone measured at least one time between 4 and 10 weeks of gestation were included. The association between progesterone concentration both continuous and as categorical variable (quartile) and the risk of preterm delivery was assessed with Cox proportional hazards regression. Differences of length of gestation in four progesterone concentration quartiles were assessed using the Log-rank test. Results: We studied 1860 mother-newborn pairs. The mean overall progesterone concentration was 65.7 ± 21.3 nmol/L, with mean progesterone concentrations in the four quartiles of 42.4 ± 6.2 nmol/L ( n = 463), 56.2 ± 3.3 nmol/L ( n = 462), 68.9 ± 4.5 nmol/L ( n = 470), and 95.1 ± 15.3 nmol/L ( n = 465). There was no significantly difference in duration of gestation in four progesterone concentration groups ( p =.511). There was no relation between progesterone level and preterm delivery (adjusted hazard ratio (HR) per 10 nmol/l progesterone level 1.00 (95% confidence interval (CI) 0.90, 1.11)). After adjusting for potential confounders, the HR of any preterm delivery for quartiles 1, 2 and 3 versus the highest quartile of progesterone level (> 77.3 nmol/L) was 1.04 (95% CI 0.52, 2.07), 1.17 (95% CI 0.60, 2.28), and 1.46 (95% CI 0.76, 2.78), respectively. When analysis was done for spontaneous preterm delivery only, also no association with first trimester progesterone was found. Conclusion: Lower first trimester serum progesterone concentration is not associated with reduction of length of gestation or increased risk of preterm delivery. |
| فهرسة مساهمة: | Keywords: Progesterone; duration of pregnancy; early pregnancy; preterm delivery |
| المشرفين على المادة: | 4G7DS2Q64Y (Progesterone) |
| تواريخ الأحداث: | Date Created: 20181127 Date Completed: 20210205 Latest Revision: 20210205 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/14767058.2018.1540580 |
| PMID: | 30474453 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4954 |
|---|---|
| DOI: | 10.1080/14767058.2018.1540580 |