دورية أكاديمية
Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections.
| العنوان: | Miconazole loaded chitosan-based nanoparticles for local treatment of vulvovaginal candidiasis fungal infections. |
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| المؤلفون: | Amaral AC; Biotechnology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO, 74605-050, Brazil. Electronic address: andre_correa_amaral@ufg.br., Saavedra PHV; VIB-UGent Center for Inflammation Research, Ghent 9052, Belgium., Oliveira Souza AC; Department of Clinical Pharmacy and Translational Science, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, 38163, United States., de Melo MT; Department of Chemistry, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-901, Brazil., Tedesco AC; Department of Chemistry, Center of Nanotechnology and Tissue Engineering-Photobiology and Photomedicine Research Group, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, 14040-901, Brazil., Morais PC; Institute of Physics, University of Brasília, Brasília, DF, 70910-900, Brazil., Soares Felipe MS; Genomic Science and Biotechnology, Catholic University of Brasília, Brasília, DF, 70790-160, Brazil., Bocca AL; Department of Cell Biology, Institute of Biological Sciences, University of Brasília, Brasília, DF, 70910-900, Brazil. |
| المصدر: | Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2019 Feb 01; Vol. 174, pp. 409-415. Date of Electronic Publication: 2018 Nov 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9315133 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4367 (Electronic) Linking ISSN: 09277765 NLM ISO Abbreviation: Colloids Surf B Biointerfaces Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier, c1993- |
| مواضيع طبية MeSH: | Antifungal Agents/*pharmacology , Candida albicans/*drug effects , Candidiasis, Vulvovaginal/*drug therapy , Chitosan/*chemistry , Miconazole/*pharmacology , Nanoparticles/*administration & dosage, Administration, Intravaginal ; Animals ; Antifungal Agents/chemistry ; Candidiasis, Vulvovaginal/microbiology ; Female ; Humans ; Mice ; Mice, Inbred BALB C ; Miconazole/chemistry ; Nanoparticles/chemistry |
| مستخلص: | Objectives: In this study, polymeric nanoparticles based on chitosan incorporating the antifungal miconazole nitrate were fabricated and testedin vivo using murine vulvovaginal candidiasis. Methods: Nanoparticles prepared by the ionotropic gelation method presented 200 to 300 nm diameter and polydispersity indexes ranging from 0.2 to 0.4. The nanoparticles were prepared to incorporate 63.9 mg/mL of miconazole nitrate to be testedin vivo. Murine vulvovaginal candidiasis was standardized using estradiol valerate before the animals were challenged by Candida albicans. Results: The treatment using chitosan nanoparticles within miconazole nitrate presented the same therapeutic efficacy as miconazole nitrate in a commercial cream formulation, however using the antifungal content about seven-fold lower. This increase in the miconazole nitrate's therapeutic efficacy is may be due to the down-regulation of interleukin 10 (IL-10) expression. Conclusions: Our data represent a proof of concept that can be exploited to achieve an alternative and promising therapy for the treatment of vulvovaginal candidiasis. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Chitosan-based nanoparticles; Miconazole; Murine vulvovaginal candidiasis |
| المشرفين على المادة: | 0 (Antifungal Agents) 7NNO0D7S5M (Miconazole) 9012-76-4 (Chitosan) |
| تواريخ الأحداث: | Date Created: 20181128 Date Completed: 20190611 Latest Revision: 20190613 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.colsurfb.2018.11.048 |
| PMID: | 30481701 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4367 |
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| DOI: | 10.1016/j.colsurfb.2018.11.048 |