دورية أكاديمية
Opportunistic screening models for high-risk men and women to detect diastolic dysfunction and heart failure with preserved ejection fraction in the community.
| العنوان: | Opportunistic screening models for high-risk men and women to detect diastolic dysfunction and heart failure with preserved ejection fraction in the community. |
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| المؤلفون: | Gohar A; 1 Julius Center for Health Sciences and Primary Care, Utrecht University, The Netherlands.; 2 Laboratory for Experimental Cardiology, Utrecht University, The Netherlands., Kievit RF; 1 Julius Center for Health Sciences and Primary Care, Utrecht University, The Netherlands., Valstar GB; 2 Laboratory for Experimental Cardiology, Utrecht University, The Netherlands., Hoes AW; 1 Julius Center for Health Sciences and Primary Care, Utrecht University, The Netherlands., Van Riet EE; 1 Julius Center for Health Sciences and Primary Care, Utrecht University, The Netherlands., van Mourik Y; 1 Julius Center for Health Sciences and Primary Care, Utrecht University, The Netherlands., Bertens LC; 3 Department of Obstetrics and Gynaecology, Erasmus Medical Center, The Netherlands., Boonman-Winter LJ; 4 Amphia Academy, The Netherlands., Bots ML; 1 Julius Center for Health Sciences and Primary Care, Utrecht University, The Netherlands., Den Ruijter HM; 2 Laboratory for Experimental Cardiology, Utrecht University, The Netherlands., Rutten FH; 1 Julius Center for Health Sciences and Primary Care, Utrecht University, The Netherlands. |
| المصدر: | European journal of preventive cardiology [Eur J Prev Cardiol] 2019 Apr; Vol. 26 (6), pp. 613-623. Date of Electronic Publication: 2018 Nov 27. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Validation Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101564430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-4881 (Electronic) Linking ISSN: 20474873 NLM ISO Abbreviation: Eur J Prev Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [Oxford] : Oxford University Press Original Publication: London : Sage |
| مواضيع طبية MeSH: | Mass Screening* , Stroke Volume* , Ventricular Function, Left*, Heart Failure/*diagnosis , Ventricular Dysfunction, Left/*diagnosis, Aged ; Aged, 80 and over ; Diastole ; Female ; Health Status ; Heart Failure/epidemiology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Primary Health Care ; Prognosis ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Ventricular Dysfunction, Left/epidemiology ; Ventricular Dysfunction, Left/physiopathology ; Ventricular Dysfunction, Left/therapy |
| مستخلص: | Background: The prevalence of undetected left ventricular diastolic dysfunction is high, especially in the elderly with comorbidities. Left ventricular diastolic dysfunction is a prognostic indicator of heart failure, in particularly of heart failure with preserved ejection fraction and of future cardiovascular and all-cause mortality. Therefore we aimed to develop sex-specific diagnostic models to enable the early identification of men and women at high-risk of left ventricular diastolic dysfunction with or without symptoms of heart failure who require more aggressive preventative strategies. Design: Individual patient data from four primary care heart failure-screening studies were analysed (1371 participants, excluding patients classified as heart failure and left ventricular ejection fraction <50%). Methods: Eleven candidate predictors were entered into logistic regression models to be associated with the presence of left ventricular diastolic dysfunction/heart failure with preserved ejection fraction in men and women separately. Internal-external cross-validation was performed to develop and validate the models. Results: Increased age and β-blocker therapy remained as predictors in both the models for men and women. The model for men additionally consisted of increased body mass index, moderate to severe shortness of breath, increased pulse pressure and history of ischaemic heart disease. The models performed moderately and similarly well in men (c-statistics range 0.60-0.75) and women (c-statistics range 0.51-0.76) and the performance improved significantly following the addition of N-terminal pro b-type natriuretic peptide (c-statistics range 0.61-0.80 in women and 0.68-0.80 in men). Conclusions: We provide an easy-to-use screening tool for use in the community, which can improve the early detection of left ventricular diastolic dysfunction/heart failure with preserved ejection fraction in high-risk men and women and optimise tailoring of preventive interventions. |
| التعليقات: | Comment in: Eur J Prev Cardiol. 2019 Apr;26(6):611-612. (PMID: 30722679) Comment in: Eur J Prev Cardiol. 2019 Oct;26(15):1666-1669. (PMID: 31319716) |
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| فهرسة مساهمة: | Keywords: Screening; community; heart failure with preserved ejection fraction; left ventricular diastolic dysfunction; sex |
| تواريخ الأحداث: | Date Created: 20181129 Date Completed: 20200819 Latest Revision: 20200819 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6431757 |
| DOI: | 10.1177/2047487318816774 |
| PMID: | 30482050 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2047-4881 |
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| DOI: | 10.1177/2047487318816774 |