دورية أكاديمية
أعرض في EDS

DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.

التفاصيل البيبلوغرافية
العنوان: DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.
المؤلفون: Yousefelahiyeh M; Department of Biological Sciences, California State University Los Angeles, Los Angeles, California, United States of America., Xu J; Department of Biological Sciences, California State University Los Angeles, Los Angeles, California, United States of America., Alvarado E; Department of Biological Sciences, California State University Los Angeles, Los Angeles, California, United States of America., Yu Y; Department of Biological Sciences, California State University Los Angeles, Los Angeles, California, United States of America., Salven D; Department of Biological Sciences, California State University Los Angeles, Los Angeles, California, United States of America., Nissen RM; Department of Biological Sciences, California State University Los Angeles, Los Angeles, California, United States of America.
المصدر: PloS one [PLoS One] 2018 Nov 29; Vol. 13 (11), pp. e0207779. Date of Electronic Publication: 2018 Nov 29 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Protein Serine-Threonine Kinases/*metabolism , Protein-Tyrosine Kinases/*metabolism, Adaptor Proteins, Signal Transducing/deficiency ; Adaptor Proteins, Signal Transducing/genetics ; Gene Expression Regulation ; Gene Knockdown Techniques ; HeLa Cells ; Humans ; Protein Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; Transcription, Genetic ; Dyrk Kinases
مستخلص: Overexpression of the Dual-specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) gene contributes to the retardation, craniofacial anomalies, cognitive impairment, and learning and memory deficits associated with Down Syndrome (DS). DCAF7/HAN11/WDR68 (hereafter WDR68) binds DYRK1A and is required for craniofacial development. Accumulating evidence suggests DYRK1A-WDR68 complexes enable proper growth and patterning of multiple organ systems and suppress inappropriate cell growth/transformation by regulating the balance between proliferation and differentiation in multiple cellular contexts. Here we report, using engineered mouse C2C12 and human HeLa cell lines, that WDR68 is required for normal levels of DYRK1A. However, Wdr68 does not significantly regulate Dyrk1a mRNA expression levels and proteasome inhibition did not restore DYRK1A in cells lacking Wdr68 (Δwdr68 cells). Overexpression of WDR68 increased DYRK1A levels while overexpression of DYRK1A had no effect on WDR68 levels. We further report that WDR68 is similarly required for normal levels of the closely related DYRK1B kinase and that both DYRK1A and DYRK1B are essential for the transition from proliferation to differentiation in C2C12 cells. These findings reveal an additional role of WDR68 in DYRK1A-WDR68 and DYRK1B-WDR68 complexes.
Competing Interests: The authors have declared that no competing interests exist.
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معلومات مُعتمدة: R15 DE022902 United States DE NIDCR NIH HHS
المشرفين على المادة: 0 (Adaptor Proteins, Signal Transducing)
0 (DCAF7 protein, human)
EC 2.7.10.1 (Protein-Tyrosine Kinases)
EC 2.7.11.1 (Protein Serine-Threonine Kinases)
تواريخ الأحداث: Date Created: 20181130 Date Completed: 20190422 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC6264848
DOI: 10.1371/journal.pone.0207779
PMID: 30496304
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0207779