دورية أكاديمية
أعرض في EDS

Measurement of spinal cord atrophy using phase sensitive inversion recovery (PSIR) imaging in motor neuron disease.

التفاصيل البيبلوغرافية
العنوان: Measurement of spinal cord atrophy using phase sensitive inversion recovery (PSIR) imaging in motor neuron disease.
المؤلفون: Olney NT; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, United States of America.; Department of Neurology, University of California San Francisco Amyotrophic Lateral Sclerosis Center, University of California San Francisco, San Francisco, California, United States of America., Bischof A; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.; Department of Neurology and Immunology Clinic, Departments of Medicine, Biomedicine and Clinical Research, University Hospital Basel, Basel, Switzerland., Rosen H; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, United States of America., Caverzasi E; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America., Stern WA; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America., Lomen-Hoerth C; Department of Neurology, University of California San Francisco Amyotrophic Lateral Sclerosis Center, University of California San Francisco, San Francisco, California, United States of America., Miller BL; Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, California, United States of America., Henry RG; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America., Papinutto N; Department of Neurology, University of California San Francisco, San Francisco, California, United States of America.
المصدر: PloS one [PLoS One] 2018 Nov 29; Vol. 13 (11), pp. e0208255. Date of Electronic Publication: 2018 Nov 29 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Motor Neuron Disease/*pathology , Spinal Cord/*pathology, Adult ; Aged ; Amyotrophic Lateral Sclerosis/diagnostic imaging ; Amyotrophic Lateral Sclerosis/pathology ; Atrophy/diagnostic imaging ; Atrophy/pathology ; Female ; Frontotemporal Dementia/diagnostic imaging ; Frontotemporal Dementia/pathology ; Gray Matter/diagnostic imaging ; Gray Matter/pathology ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Motor Neuron Disease/diagnostic imaging ; Spinal Cord/diagnostic imaging ; White Matter/diagnostic imaging ; White Matter/pathology
مستخلص: Background: The spectrum of motor neuron disease (MND) includes numerous phenotypes with various life expectancies. The degree of upper and lower motor neuron involvement can impact prognosis. Phase sensitive inversion recovery (PSIR) imaging has been shown to detect in vivo gray matter (GM) and white matter (WM) atrophy in the spinal cord of other patient populations but has not been explored in MND.
Methods: In this study, total cord, WM and GM areas of ten patients with a diagnosis within the MND spectrum were compared to those of ten healthy controls (HC). Patients' diagnosis included amyotrophic lateral sclerosis (ALS), primary lateral sclerosis, primary muscular atrophy, facial onset sensory and motor neuronopathy and ALS-Frontotemporal dementia. Axial 2D PSIR images were acquired at four cervical disc levels (C2-C3, C3-C4, C5-C6 and C7-T1) with a short acquisition time (2 minutes) protocol. Total cross-sectional areas (TCA), GM and WM areas were measured using a combination of highly reliable manual and semi-automated methods. Cord areas in MND patients were compared with HC using linear regression analyses adjusted for age and sex. Correlation of WM and GM areas in MND patients was explored to gain insights into underlying atrophy patterns.
Results: MND patients as a group had significantly smaller cervical cord GM area compared to HC at all four levels (C2-C3: p = .009; C3-C4: p = .001; C5-C6: p = .006; C7-T1: p = .002). WM area at C5-C6 level was significantly smaller (p = .001). TCA was significantly smaller at C3-C4 (p = .018) and C5-C6 (p = .002). No significant GM and WM atrophy was detected in the two patients with predominantly bulbar phenotype. Concomitant GM and WM atrophy was detected in solely upper or lower motor neuron level phenotypes. There was a significant correlation between GM and WM areas at all four levels in this diverse population of MND.
Conclusion: Spinal cord GM and WM atrophy can be detected in vivo in patients within the MND spectrum using a short acquisition time 2D PSIR imaging protocol. PSIR imaging shows promise as a method for quantifying spinal cord involvement and thus may be useful for diagnosis, prognosis and for monitoring disease progression.
Competing Interests: Dr. Miller has served as an Advisor/Director to The Tau Consortium, The John Douglas French Foundation, The Larry L. Hillblom Foundation, Medical Advisory Board, National Institute for Health Research, Cambridge Biomedical Research Centre and its subunit, the Biomedical Research Unit in Dementia (UK); he has served as an External Advisor to University of Washington ADRC, Stanford University ADRC, and University of Pittsburgh ADRC; he receives royalties from Cambridge University Press, Guilford Publications, Inc., and Neurocase. AB reports travel fees from Actelion. NTO has received consulting fees from Avanir pharmaceuticals while participating in the visiting expert program to discuss his prior work on pseudobulbar affect in ALS. All other authors have no conflicts of interest to report. This does not alter our adherence to PLOS ONE policies on sharing data and materials.
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معلومات مُعتمدة: U01 AG045390 United States AG NIA NIH HHS; P01 AG019724 United States AG NIA NIH HHS
SCR Disease Name: Frontotemporal Dementia With Motor Neuron Disease
تواريخ الأحداث: Date Created: 20181130 Date Completed: 20190506 Latest Revision: 20200309
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6264489
DOI: 10.1371/journal.pone.0208255
PMID: 30496320
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0208255