دورية أكاديمية
Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition.
| العنوان: | Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition. |
|---|---|
| المؤلفون: | Hu XF; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Zhang WY; Department of Geriatrics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Wen Q; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Chen WJ; Department of Rehabilitation, Huazhong University of Science and Technology Hospital, China., Wang ZM; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Health, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, China., Chen J; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Zhu F; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Liu K; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Cheng LX; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China., Yang J; Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Health, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, China. Electronic address: jy@tjh.tjmu.edu.cn., Shu YW; Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, China. Electronic address: yanwenshu163@163.com. |
| المصدر: | Pharmacological research [Pharmacol Res] 2019 Jan; Vol. 139, pp. 412-421. Date of Electronic Publication: 2018 Nov 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oct. 2015- : Amsterdam ; Elsevier Original Publication: London ; San Diego : Academic Press, c1989- |
| مواضيع طبية MeSH: | Fecal Microbiota Transplantation*, Dysbiosis/*therapy , Myocarditis/*therapy, Animals ; Dysbiosis/microbiology ; Dysbiosis/pathology ; Male ; Mice, Inbred BALB C ; Microbiota ; Myocarditis/microbiology ; Myocarditis/pathology ; Myocardium/pathology |
| مستخلص: | Myocarditis can be caused by several infectious and noninfectious causes. Treatment for myocarditis is still a difficult task in clinical practice. The gut microbiota is related to cardiovascular diseases such as atherosclerosis and hypertension. However, little is known about the role of the gut microbiota in myocarditis. In our study, we tested the hypothesis that gut dysbiosis is associated with myocarditis. We focused on whether fecal microbiota transplantation (FMT) can be used as an effective treatment for myocarditis. We used an experimental autoimmune myocarditis (EAM) mouse model. Fecal samples were isolated from the control and EAM groups for bacterial genome analysis. We observed an increase in microbial richness and diversity in the myocarditis mice. These changes were accompanied by an increased Firmicutes/Bacteroidetes ratio. We also evaluated the efficacy of FMT for the treatment of myocarditis. EAM mouse guts were repopulated with fecal contents from an untreated male mouse donor. We found that myocardial injury was improved by diminished inflammatory infiltration, showing that IFN-γ gene expression in the heart tissue and CD4 + IFN-γ + cells in the spleen were decreased after FMT in EAM mice. We also found that FMT was able to rebalance the gut microbiota by restoring the Bacteroidetes population and reshaping the microbiota composition. Myocarditis is associated with gut microbiota dysbiosis and characterized by an increased F/B ratio. FMT treatment can rebalance the gut microbiota and attenuate myocarditis. Thus, FMT may be a potential therapeutic strategy for the treatment of myocarditis. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Dysbiosis; Fecal microbiota transplantation; Microbiota; Myocarditis |
| تواريخ الأحداث: | Date Created: 20181204 Date Completed: 20190514 Latest Revision: 20190514 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.phrs.2018.11.042 |
| PMID: | 30508676 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-1186 |
|---|---|
| DOI: | 10.1016/j.phrs.2018.11.042 |