Propofol adsorption at the air/water interface: a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study.

التفاصيل البيبلوغرافية
العنوان:	Propofol adsorption at the air/water interface: a combined vibrational sum frequency spectroscopy, nuclear magnetic resonance and neutron reflectometry study.
المؤلفون:	Niga P; RISE Research Institutes of Sweden - Chemistry, Materials and Surfaces, Box 5607, SE-114 86 Stockholm, Sweden. petru.niga@ri.se., Hansson-Mille PM; RISE Research Institutes of Sweden - Chemistry, Materials and Surfaces, Box 5607, SE-114 86 Stockholm, Sweden. petru.niga@ri.se., Swerin A; RISE Research Institutes of Sweden - Chemistry, Materials and Surfaces, Box 5607, SE-114 86 Stockholm, Sweden. petru.niga@ri.se and KTH Royal Institute of Technology, Department of Chemistry, Division of Surface and Corrosion Science, SE-100 44 Stockholm, Sweden. magnusj@kth.se., Claesson PM; RISE Research Institutes of Sweden - Chemistry, Materials and Surfaces, Box 5607, SE-114 86 Stockholm, Sweden. petru.niga@ri.se and KTH Royal Institute of Technology, Department of Chemistry, Division of Surface and Corrosion Science, SE-100 44 Stockholm, Sweden. magnusj@kth.se., Schoelkopf J; Omya International AG, Baslerstrasse 42, CH-4665 Oftringen, Switzerland., Gane PAC; Omya International AG, Baslerstrasse 42, CH-4665 Oftringen, Switzerland and Aalto University, School of Chemical Technology, Department of Bioproducts and Biosystems, FI-00076 Aalto, Helsinki, Finland., Dai J; KTH Royal Institute of Technology, Department of Chemistry, Division of Applied Physical Chemistry, SE-100 44 Stockholm, Sweden., Furó I; KTH Royal Institute of Technology, Department of Chemistry, Division of Applied Physical Chemistry, SE-100 44 Stockholm, Sweden., Campbell RA; Institut Laue-Langevin, 71 Avenue des Martyrs, CS20156, 38042 Grenoble Cedex 9, France and Division of Pharmacy and Optometry, University of Manchester, Manchester M13 9PT, UK., Johnson CM; KTH Royal Institute of Technology, Department of Chemistry, Division of Surface and Corrosion Science, SE-100 44 Stockholm, Sweden. magnusj@kth.se.
المصدر:	Soft matter [Soft Matter] 2018 Dec 19; Vol. 15 (1), pp. 38-46.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101295070 Publication Model: Print Cited Medium: Internet ISSN: 1744-6848 (Electronic) Linking ISSN: 1744683X NLM ISO Abbreviation: Soft Matter Subsets: PubMed not MEDLINE
أسماء مطبوعة:	Original Publication: Cambridge, England : Royal Society of Chemistry, 2005-
مستخلص:	Propofol is an amphiphilic small molecule that strongly influences the function of cell membranes, yet data regarding interfacial properties of propofol remain scarce. Here we consider propofol adsorption at the air/water interface as elucidated by means of vibrational sum frequency spectroscopy (VSFS), neutron reflectometry (NR), and surface tensiometry. VSFS data show that propofol adsorbed at the air/water interface interacts with water strongly in terms of hydrogen bonding and weakly in the proximity of the hydrocarbon parts of the molecule. In the concentration range studied there is almost no change in the orientation adopted at the interface. Data from NR show that propofol forms a dense monolayer with a thickness of 8.4 Å and a limiting area per molecule of 40 Å2, close to the value extracted from surface tensiometry. The possibility that islands or multilayers of propofol form at the air/water interface is therefore excluded as long as the solubility limit is not exceeded. Additionally, measurements of the 1H NMR chemical shifts demonstrate that propofol does not form dimers or multimers in bulk water up to the solubility limit.
تواريخ الأحداث:	Date Created: 20181206 Date Completed: 20181221 Latest Revision: 20190110
رمز التحديث:	20231215
DOI:	10.1039/c8sm01677a
PMID:	30516226
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1744-6848
DOI:	10.1039/c8sm01677a